Precision medicine in orthopaedics: A review of current technologies and future directions.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Michael T. Hirschmann: Consulting fees from Depuy Synthes and Symbios; Honoraria for Lectures and Support attending Meetings from Depuy Synthes, Symbios, and S&N; Participation on Advisory Board for Depuy Synthes; Leadership positions in KSSTA Journal, ESSKA, German Knee Society and Personalised Arthroplasty Society. Patrick Sadoghi: Industry grants from DePuy Synthes, Johnson & Johnson, alphamed, and Medacta; Editorial Board Member for JOA, KSSTA and Arthroscopy. Giuseppe Milano: ESSKA Journals Deputy EiC or Associate Editor, Medacta: Research support; Arthrex: Research support, FGP: Research support; Medics: Research grant, Rotator Cuff Study Group: Chairman, Arthroscopy: Emeritus Associate Editor, Minerva Orthopaedics: Associate Editor; Joints: Funding Editor. Elmar Herbst: Deputy Editor‐in‐Chief of Knee Surgery, Sports Traumatology & Arthroscopy (KSSTA). Volker Musah: Grants: NIH, DOD, Consulting fees: NewClip, Smith & Nephew, Patents: Ipad Technology, ACL Study Group, Stock: Ostesys. The remaining author declares no conflicts of interest. 9. EFORT Open Rev. 2025 Sep 4;10(9):646-659. doi: 10.1530/EOR-2025-0071. Evolutionary patterns and future perspectives of joint replacement in arthritis patients: a comprehensive analysis of findings over the past decades. Tao SS(1)(2)(3), Tang J(1)(2), Liu YC(4), Xu SZ(1)(2), Chen Z(5), Pan HF(1)(2). Author information: (1)Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. (2)Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China. (3)Preventive Medicine Experimental Teaching Center, School of Public Health, Anhui Medical University, Hefei, Anhui, China. (4)Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. (5)Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui,China. PURPOSE: This study aimed to comprehensively review the current research status and trends of joint replacement for arthritis patients worldwide. METHODS: Literature related to joint replacement for arthritis patients from 2004 to 2024 was extracted from the Web of Science Core Collection (WoSCC) database. A systematic qualitative and quantitative analysis of these publications was conducted. Visualization of results was achieved using CiteSpace and VOSviewer software. RESULTS: In total, 14,349 publications met the inclusion and exclusion criteria and were selected for further research. Keyword analysis revealed a clinical emphasis on optimizing surgical outcomes through advancements in total knee arthroplasty, total hip arthroplasty, and patient-centered metrics. Emerging research hotspots since 2020 included precision techniques such as robotic-assisted surgery, strategies to address periprosthetic joint infection, and the role of psychological factors such as depression and patient satisfaction. Temporal trends highlighted evolving priorities, including personalized alignment protocols, where the burst intensities of kinematic alignment and mechanical alignment were 16.33 and 13.79, respectively, as well as functional recovery and complication prevention. Historical dominance of rheumatoid arthritis research has transitioned to broader exploration of osteoarthritis management and technological innovations in surgical precision. CONCLUSION: This study revealed a marked transition from rheumatoid arthritis-focused studies to innovations in osteoarthritis management and precision surgical techniques. Clinically, these findings emphasize the need to integrate technological advancements with multidisciplinary frameworks to standardize infection control, optimize implant durability, and enhance rehabilitation outcomes. Future efforts should prioritize personalized alignment strategies, evidence-based infection control protocols, and multidisciplinary rehabilitation frameworks to improve long-term functional outcomes. DOI: 10.1530/EOR-2025-0071 PMCID: PMC12412288