Adenosine, lidocaine and Mg(2+) update: teaching old drugs new tricks.

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Abstract

Conflict of interest statement: GD is sole inventor of the ALM concept for cardiac surgery, trauma and sepsis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 18. Eur J Trauma Emerg Surg. 2017 Aug;43(4):439-443. doi: 10.1007/s00068-017-0771-0. Epub 2017 Feb 27. Volume replacement during trauma resuscitation: a brief synopsis of current guidelines and recommendations. Maegele M(1)(2), Fröhlich M(3), Caspers M(3)(4), Kaske S(3). Author information: (1)Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center (CMMC), Institute for Research in Operative Medicine (IFOM), University of Witten/Herdecke (UW/H), Ostmerheimerstr. 200, 51109, Cologne, Germany. Marc.Maegele@t-online.de. (2)Institute for Research in Operative Medicine (IFOM), University Witten/Herdecke (UW/H), Campus Cologne-Merheim, Ostmerheimerstr. 200, 51109, Cologne, Germany. Marc.Maegele@t-online.de. (3)Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center (CMMC), Institute for Research in Operative Medicine (IFOM), University of Witten/Herdecke (UW/H), Ostmerheimerstr. 200, 51109, Cologne, Germany. (4)Institute for Research in Operative Medicine (IFOM), University Witten/Herdecke (UW/H), Campus Cologne-Merheim, Ostmerheimerstr. 200, 51109, Cologne, Germany. INTRODUCTION: Intravascular volume and fluid replacement are still cornerstones to correct fluid deficits during early trauma resuscitation, but optimum strategies remain under debate. METHODS: A synopsis of best current knowledge with reference to the following guidelines and recommendations is presented: (1) The European Guideline on Management of Major Bleeding and Coagulopathy following Trauma (fourth edition), (2) S3 Guideline on Treatment of Patients with Severe and Multiple Injuries [English Version of the German Guideline S3 Leitlinie Polytrauma/Schwerverletzten-Behandlung/AWMF Register-Nr. 012/019 sponsored by the German Society for Trauma Surgery/Deutsche Gesellschaft für Unfallchirurgie (DGU)], and (3) S3 Guideline Intravascular Volume Treatment in the Adult [AWMF Register-Nr 001/020 sponsored by the German Society for Anesthesiology and Intensive Medicine/Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI)]. RESULTS AND CONCLUSIONS: Volume replacement at a reduced level in severely injured and bleeding trauma patients is advocated (permissive hypotension) until the bleeding is controlled. ATLS principles with Hb, BE, and/or lactate can assess perfusion, estimate/monitor the extent of bleeding/shock, and guide therapy. Isotonic crystalloid solutions are first-line and specific recommendations apply for patients with TBI. DOI: 10.1007/s00068-017-0771-0