Fibrodysplasia ossificans progressiva emerges from obscurity.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of interests F.S.K. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron; a coinventor of a US patent (pending) to the Trustees of the University of Pennsylvania on the use of MMP-9 inhibitors for heterotopic ossification; and a member of the Medical Registry Advisory Board of the IFOPA. E.M.S. declares no competing interests. R.J.P. is a clinical trial investigator for Ashibio, Incyte, Ipsen, and Regeneron; a coinventor of U.S. patent (pending) to the Trustees of the University of Pennsylvania on the use of MMP-9 inhibitors for heterotopic ossification; a member of the Medical Registry Advisory Board of the IFOPA; and a consultant for Incyte, Ipsen, and Regeneron. 15. Biomolecules. 2024 Mar 14;14(3):349. doi: 10.3390/biom14030349. Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification. Juan C(1), Bancroft AC(1)(2), Choi JH(1), Nunez JH(1), Pagani CA(1), Lin YS(3), Hsiao EC(4), Levi B(1). Author information: (1)Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (2)Baylor College of Medicine, Houston, TX 77030, USA. (3)Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. (4)Division of Endocrinology and Metabolism, Department of Medicine, the Institute for Human Genetics, and the Program in Craniofacial Biology, University of California San Francisco Medical Center, San Francisco, CA 94143, USA. Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of dysregulated osteogenic signaling, as in the case of the orphan disease fibrodysplasia ossificans progressiva (FOP). Traumatic HO (tHO) formation is mediated by the complex interplay of signaling between progenitor, inflammatory, and nerve cells, among others, making it a challenging process to understand. Research into the pathogenesis of genetically mediated HO (gHO) in FOP has established a pathway involving uninhibited activin-like kinase 2 receptor (ALK2) signaling that leads to downstream osteogenesis. Current methods of diagnosis and treatment lag behind pre-mature HO detection and progressive HO accumulation, resulting in irreversible decreases in range of motion and chronic pain for patients. As such, it is necessary to draw on advancements made in the study of tHO and gHO to better diagnose, comprehend, prevent, and treat both. DOI: 10.3390/biom14030349 PMCID: PMC10968060