Pathogenesis of haemophilic arthropathy.

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Abstract

[Indexed for MEDLINE] 12. Cytokine Growth Factor Rev. 2018 Feb;39:71-91. doi: 10.1016/j.cytogfr.2017.11.003. Epub 2017 Nov 13. Cytokines in the pathogenesis of hemophilic arthropathy. Wojdasiewicz P(1), Poniatowski ŁA(2), Nauman P(3), Mandat T(4), Paradowska-Gorycka A(5), Romanowska-Próchnicka K(6), Szukiewicz D(7), Kotela A(8), Kubaszewski Ł(9), Kotela I(10), Kurkowska-Jastrzębska I(11), Gasik R(12). Author information: (1)Department of General and Experimental Pathology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland; Department of Rheumaorthopaedics, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland; Department of Neuroorthopaedics and Neurology, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. Electronic address: piotr.wojdasiewicz@wum.edu.pl. (2)Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland. Electronic address: lukasz.poniatowski@gmail.com. (3)Department of Neurosurgery, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland. Electronic address: pnauman@ipin.edu.pl. (4)Department of Neurosurgery, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland; Department of Neurosurgery, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, W. K. Roentgena 5, 02-781 Warsaw, Poland. Electronic address: tomaszmandat@yahoo.com. (5)Department of Biochemistry and Molecular Biology, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. Electronic address: paradowska_aga@interia.pl. (6)Department of General and Experimental Pathology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland; Department of Systemic Connective Tissue Diseases, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. Electronic address: katarzyna.prochnicka@gmail.com. (7)Department of General and Experimental Pathology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, Poland. Electronic address: dszukiewicz@hotmail.com. (8)Department of Orthopaedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland; Department of Orthopaedics and Traumatology, Central Clinical Hospital of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland. Electronic address: andrzejkotela@op.pl. (9)Department of Spondyloorthopaedics and Biomechanics of the Spine, Wiktor Dega Orthopaedic and Rehabilitation Clinical Hospital, Poznań University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznań, Poland; Department of Orthopaedics and Traumatology, Wiktor Dega Orthopaedic and Rehabilitation Clinical Hospital, Poznań University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznań, Poland. Electronic address: pismiennictwo1@gmail.com. (10)Department of Orthopaedics and Traumatology, Central Clinical Hospital of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, Poland. Electronic address: ikotela@op.pl. (11)2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland. Electronic address: ikurkowska@ipin.edu.pl. (12)Department of Neuroorthopaedics and Neurology, Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Spartańska 1, 02-637 Warsaw, Poland. Electronic address: robertgasik2@gmail.com. Hemophilic arthropathy (HA) is one of the most common and typical manifestation in the course of recurrent bleeding episodes in patients with hemophilia. Clinical and subclinical joint bleeding episodes gradually lead to irreversible changes manifesting themselves as pain, progressing ankylosis, marked limitation of the range of motion, muscle atrophy and osteoporosis commonly concomitant with joint deformity resulting from chronic proliferative synovitis and both cartilage and bone degeneration leading to the final functional impairment of the joint. In spite of numerous studies, the pathophysiology of HA has not been fully elucidated, especially as regards immunopathological mechanisms which are associated with the subclinical and early stage of the disease and to be more precise, with chronic joint inflammation. It needs to be emphasized that the pathophysiological processes occurring in a joint with HA are most probably highly mediated by interactions within the cytokine network and other inflammatory mediators present in the tissues of affected joint. Among numerous compounds participating in the induction of an inflammatory process in the pathogenesis of HA, cytokines seem to play a leading role. The most important group controlling the disease seems to be well known inflammatory cytokines, including IL-1β, TNFα and IL-6. The second group with antagonistic effect is formed by anti-inflammatory cytokines such as IL-4 and IL-10. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of HA with respect to cellular and intracellular signaling pathways is still under investigation. This review, summarizes and discusses the current knowledge about cytokine network in the pathogenesis of HA, indicating possible molecular and cellular mechanisms that may provide potential new therapeutic directions. Copyright © 2017 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.cytogfr.2017.11.003