Optimizing long-term joint health in the treatment of hemophilia.

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Abstract

[Indexed for MEDLINE] 11. Blood Rev. 2012 Sep;26(5):213-21. doi: 10.1016/j.blre.2012.06.003. Epub 2012 Jul 6. Biomechanics of lower limb haemophilic arthropathy. Stephensen D(1), Drechsler WI, Scott OM. Author information: (1)School of Health, Sport and Bioscience, University of East London, London, UK. david.stephensen@ekht.nhs.uk Intermittent joint bleeding and potential arthropathy remain a concern for patients and those responsible for haemophilic care. Monitoring the status of haemophilic joints is a current challenge. Evaluation of bone and soft tissue with radiological imaging together with clinical joint scoring is often used to monitor haemophilic arthropathy and may not be sufficiently sensitive to early changes in joint morphology. Recently an interest in the biomechanical status of haemophilic joints has emerged. Biomechanics is defined as the interdiscipline that describes, analyses and assesses movement in relation to biological and physical principles. This review considers the biomechanical evaluation of haemophilic joint status of the lower limb with particular reference to the evaluation of muscle atrophy, muscle strength, range of motion and gait as well as the relationship to haemophilic arthropathy. In raising the need for increased clinical awareness, this review highlights the need to establish test-retest and inter-rater reliability and ensuring that comparative studies are undertaken with age-matched unaffected peer groups. Copyright © 2012 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.blre.2012.06.003