Journal of orthopaedic research : official publication of the Orthopaedic Research Society | 2006 | Langenderfer JE, Patthanacharoenphon C, Carpenter JE, Hughes RE
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[Indexed for MEDLINE] 20. J Orthop Surg Res. 2026 Apr 19. doi: 10.1186/s13018-026-06831-2. Online ahead of print. A comparative study of the clinical value of PRP and microfracture techniques in the repair of rotator cuff injuries. Li S(#)(1)(2), Lan Q(#)(1)(2), Liu X(3), Zhan Y(3), Kang Q(4), Zheng J(1)(2), Tang F(5)(6), Guo H(7)(8). Author information: (1)Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, P. R. China. (2)Orthopaedic and Sports Medicine Centre, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, P. R. China. (3)Union Clinical Medical College, Fujian Medical University, Fuzhou, 350001, P. R. China. (4)The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350004, P. R. China. (5)Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, P. R. China. faqiangtang@fzu.edu.cn. (6)Orthopaedic and Sports Medicine Centre, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, P. R. China. faqiangtang@fzu.edu.cn. (7)Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, P. R. China. ghl5910778@163.com. (8)Orthopaedic and Sports Medicine Centre, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, P. R. China. ghl5910778@163.com. (#)Contributed equally OBJECTIVE: To compare the clinical value of platelet-rich plasma (PRP) therapy versus microfracture technique in rotator cuff repair. METHODS: A retrospective study included 142 patients undergoing rotator cuff repair surgery, divided into PRP, microfracture, and control groups. Postoperative tendon-bone union, shoulder function scores (ASES, UCLA), pain scores (VAS), and complication rates were compared across groups. RESULTS: Baseline characteristics were comparable across groups. Both PRP and microfracture techniques effectively promoted tendon-bone healing and improved shoulder function, outperforming the control group. Safety profiles were equivalent between the two intervention groups. However, early VAS scores indicated higher pain levels in the microfracture group compared to both the PRP group and control groups. CONCLUSION: Both PRP and microfracture techniques demonstrate sound clinical utility and safety in rotator cuff repair. PRP yields milder early postoperative pain, while microfracture offers cost advantages. Clinicians may tailor intervention choices based on individual patient factors including pain tolerance and financial circumstances. © 2026. The Author(s). DOI: 10.1186/s13018-026-06831-2
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