Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process.

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Abstract

Conflict of interest statement: The authors declare no conflicts of interest. 8. Int J Mol Med. 2019 Oct;44(4):1281-1288. doi: 10.3892/ijmm.2019.4298. Epub 2019 Aug 2. Aspirin alleviates orthopedic implant‑associated infection. Jiang Y(1), Wang SN(1), Wu HT(2), Qin HJ(2), Ren ML(2), Lin JC(2), Yu B(1). Author information: (1)Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China. (2)Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China. Implant‑associated infection (IAI), a common condition marked by progressive inflammation and bone destruction, is mentally and financially devastating to those it affects, causing severe morbidity, prolonged hospital admissions, significant hospital costs and, in certain cases, mortality. Aspirin, a popular synthetic compound with a history of >100 years, is antipyretic, anti‑inflammatory and analgesic. It is the most active component of non‑steroidal anti‑inflammatory drugs. However, the effects of aspirin on IAI remain unknown. In the present study, an IAI animal model was used, in which a stainless steel pin coated with Staphylococcus aureus was implanted through the left shaft of the tibia in mice. The animals were then randomized into five groups and subjected respectively to IAI, IAI + 15 mg aspirin treatment, IAI + 30 mg aspirin treatment, IAI + 60 mg aspirin treatment and IAI + 120 mg aspirin treatment groups. Aspirin was injected intraperitoneally twice daily for 11 days. Micro‑CT and histological assays were performed to assess the effects of aspirin on IAI. It was found that aspirin reduced osteolysis and periosteal reaction, inhibited the activation of osteoclasts, promoted the activation of osteoblasts and facilitated healing of the infected fracture. DOI: 10.3892/ijmm.2019.4298 PMCID: PMC6713404