MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflicts of interest with the contents of this article 7. J Spine Surg. 2020 Dec;6(4):793-799. doi: 10.21037/jss-20-497. Comprehensive treatment algorithm of postoperative spinal implant infection. Bürger J(1), Palmowski Y(1), Pumberger M(1). Author information: (1)Center for Musculoskeletal Surgery, Charité University Medicine Berlin, Berlin, Germany. Postoperative spinal implant infection (PSII) is a commonly found and serious complication after instrumented spinal surgery. Whereas early-onset PSII usually can be diagnosed by clinical symptoms, the diagnosis of late-onset PSII can be often made only by examination of intraoperatively collected samples. The treatment of PSII consists of surgical and antibiotic therapy schemes. In case of early PSII, the retention of spinal implants is a feasible option, whereas late PSII is usually treated by one-staged exchange of the spinal implants. Radical debridement of surrounding tissue should be performed in any case of PSII. The antibiotic treatment depends on either the implants can be removed or need to be retained or exchanged, respectively. If the causative pathogens are sensitive for biofilm-active antibiotic agents, the duration of antibiotic treatment amounts to 12 weeks with retention of spinal implants. In case of problematic pathogens, the application of antibiotics needs to be prolonged for an individual duration. Antibiotic treatment should always be initiated with an intravenous application for at least 2 weeks. 2020 Journal of Spine Surgery. All rights reserved. DOI: 10.21037/jss-20-497 PMCID: PMC7797808