Cancer-associated bone disease.

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Abstract

[Indexed for MEDLINE] 16. J Cyst Fibros. 2019 Oct;18 Suppl 2:S56-S65. doi: 10.1016/j.jcf.2019.08.017. Cystic fibrosis bone disease treatment: Current knowledge and future directions. Putman MS(1), Anabtawi A(2), Le T(3), Tangpricha V(4), Sermet-Gaudelus I(5). Author information: (1)Divisions of Endocrinology, Boston Children's Hospital and Massachusetts General Hospital, Boston, MA, USA. Electronic address: msputman@partners.org. (2)Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA. (3)Departments of Internal Medicine and Pediatrics, Division of Endocrinology, Virginia Commonwealth University, Richmond, VA, USA. (4)Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine and the Atlanta VA Medical Center. (5)Service de Pneumo-Allergologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France; Institut Necker Enfants Malades, INSERM U1151, France. Bone disease is a frequent complication in adolescents and adults with cystic fibrosis (CF). Early detection and monitoring of bone mineral density and multidisciplinary preventive care are necessary from childhood through adolescence to minimize CF-related bone disease (CFBD) in adult CF patients. Approaches to optimizing bone health include ensuring adequate nutrition, particularly intake of calcium and vitamins D and K, addressing other secondary causes of low bone density such as hypogonadism, encouraging weight bearing exercise, and avoiding bone toxic medications. Of the currently available anti-resorptive or anabolic osteoporosis medications, only bisphosphonates have been studied in individuals with CF. Future studies are needed to better understand the optimal approach for managing CFBD. Copyright © 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. DOI: 10.1016/j.jcf.2019.08.017