Human Immunodeficiency Virus and Total Joint Arthroplasty: The Risk for Infection Is Reduced.

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Abstract

[Indexed for MEDLINE] 19. HIV Med. 2020 Dec;21(11):683-691. doi: 10.1111/hiv.13022. Multidisciplinary collaborative integrated management of increasingly prominent HIV complications in the post-cART era. Lin L(1), Li TS(1)(2)(3)(4). Author information: (1)Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. (2)Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. (3)Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China. (4)Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China. OBJECTIVES: With the prolonged survival time of AIDS patients, complications of various systems and organs of HIV infection are increasingly prominent. These diseases have become the major factors influencing the quality of life and prognosis of HIV-infected persons, and multidisciplinary cooperation treatment is urgently needed. METHODS: The Chinese HIV/AIDS Clinical Trial Network has conducted a series of multicentre clinical cohort studies over the past 16 years, in which studies related to people living with HIV systemic complications. Based on the results of previous studies, this review establishes the complications of Chinese people living with HIV after long-term cART. RESULTS: HIV's direct damage to human cells, chronic abnormal inflammatory activation after HIV infection, long-term drug side effects caused by cART and persistent reservoirs cause systemic complications in people living with HIV. We summarised the clinical characteristics of the complications of HIV infection in China from the aspects of the liver, cardiovascular, the nervous system, the kidney, bone metabolism, blood glucose, and lipid metabolism. CONCLUSIONS: The management of the complications of HIV infection is a major link in improving the survival treatment and prognosis of patients in the future. The joint participation of doctors from different departments of general hospitals in the management of comorbidities is the main theme for future improvement of quality of life and prognosis for people living with HIV. © 2020 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. DOI: 10.1111/hiv.13022 PMCID: PMC7839721