Chondrosarcoma of hyoid bone: a case report.

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Abstract

[Indexed for MEDLINE] 9. Spine J. 2021 Dec;21(12):2078-2096. doi: 10.1016/j.spinee.2021.04.021. Epub 2021 May 8. Chondrosarcoma of the spine: a narrative review. Pennington Z(1), Ehresman J(2), Pittman PD(3), Ahmed AK(4), Lubelski D(4), McCarthy EF(5), Goodwin CR(6), Sciubba DM(7). Author information: (1)Department of Neurosurgery, Mayo Clinic, Rochester, MN USA 55905; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287. Electronic address: zach.pennington.93@gmail.com. (2)Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ USA 85013. Electronic address: jehresm1@gmail.com. (3)Department of Neuropathology, Duke University School of Medicine, Durham, NC USA 27710. (4)Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287. (5)Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287. (6)Department of Neurosurgery, Duke University School of Medicine, Durham, NC USA 27710. (7)Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD USA 21287; Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, NY USA 11030. Electronic address: dsciubba1@northwell.edu. Chondrosarcoma is an uncommon primary bone tumor with an estimated incidence of 0.5 per 100,000 patient-years. Primary chondrosarcoma of the mobile spine and sacrum cumulatively account for less than 20% of all cases, most .commonly causing patients to present with focal pain with or without radiculopathy, or myelopathy secondary to neural element compression. Because of the rarity, patients benefit from multidisciplinary care at academic tertiary-care centers. Current standard-of-care consists of en bloc surgical resection with negative margins; for high grade lesions adjuvant focused radiation with ≥60 gray equivalents is taking an increased role in improving local control. Prognosis is dictated by lesion grade at the time of resection. Several groups have put forth survival calculators and epidemiological evidence suggests prognosis is quite good for lesions receiving R0 resection. Future efforts will be focused on identifying potential chemotherapeutic adjuvants and refining radiation treatments as a means of improving local control. Copyright © 2021. Published by Elsevier Inc. DOI: 10.1016/j.spinee.2021.04.021