Should we avoid shoulder surgery in wheelchair users? A systematic review of outcomes and complications.

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Abstract

[Indexed for MEDLINE] 19. Biomed Eng Online. 2025 Apr 23;24(1):46. doi: 10.1186/s12938-025-01368-7. Application and optimization of bioengineering strategies in facilitating tendon-bone healing. Yang C(#)(1)(2)(3)(4), Chen C(#)(1)(2)(3), Chen R(1)(2)(3), Yang F(1)(2)(3), Xiao H(1)(2)(3), Geng B(1)(2)(3), Xia Y(5)(6)(7). Author information: (1)Department of Orthopedics, Lanzhou University Second Hospital, No.82, Cuyingmen, Chengguan District, Lanzhou City, Gansu Province, China. (2)Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China. (3)The Second School of Clinical Medical, Lanzhou University, Lanzhou, China. (4)Department of Orthopedic, Tianshui Hand and Foot Surgery Hospital, Tianshui, China. (5)Department of Orthopedics, Lanzhou University Second Hospital, No.82, Cuyingmen, Chengguan District, Lanzhou City, Gansu Province, China. xiayy@lzu.edu.cn. (6)Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China. xiayy@lzu.edu.cn. (7)The Second School of Clinical Medical, Lanzhou University, Lanzhou, China. xiayy@lzu.edu.cn. (#)Contributed equally Tendon-bone insertion trauma is prevalent in both rotator cuff and anterior cruciate ligament injuries, which are frequently encountered conditions in the field of sports medicine. The main treatment for such injuries is reconstructive surgery. The primary determinant impacting this process is the graft's capacity to integrate with the bone tunnel. In recent years, researchers have attempted to use a variety of methods to facilitate tendon-bone healing after reconstructive surgery. Such as the implantation of biological materials, cytokines and the local application of permanently differentiated cells from various sources. However, there are limitations to the efficacy of one therapy alone in facilitating tendon-bone healing. Therefore, researchers are trying to combine strategies to overcome this conundrum. At present, most studies are based on biomaterial combined with other therapeutic strategies for tissue repair and regeneration. Biomaterials mainly include the application of bioengineering scaffolds, hydrogels and bioabsorbable interference screws. By conducting a thorough review of relevant literature, this study provides a comprehensive overview of the present research progress in enhancing tendon-bone healing using biomaterials. Additionally, it explores the potential benefits of combining biomaterials with other approaches to promote tendon-bone healing. The ultimate goal is to offer insights for future basic research endeavors and establish a solid groundwork for advancing clinical applications in the near future. © 2025. The Author(s). DOI: 10.1186/s12938-025-01368-7 PMCID: PMC12016306