Magnetic resonance imaging after total hip arthroplasty: evaluation of periprosthetic soft tissue.

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Abstract

[Indexed for MEDLINE] 11. J Nanobiotechnology. 2023 Oct 31;21(1):398. doi: 10.1186/s12951-023-02177-7. PLGA nanoparticles engineering extracellular vesicles from human umbilical cord mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic osteolysis. Xie J(1), Hu Y(1), Su W(2), Chen S(3), Wang J(4), Liang S(4), Chen M(3), Wang H(4), Ma T(5). Author information: (1)Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. (2)Department of Orthopaedics, The 3rd Xiangya Hospital, Central South University, Changsha, China. (3)Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, China. (4)Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. (5)Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. tianliangma@163.com. The wear particle-induced dissolution of bone around implants is a significant pathological factor in aseptic loosening, and controlling prosthetic aseptic loosening holds crucial social significance. While human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exos, Exos) have been found to effectively promote osteogenesis and angiogenesis, their role in periprosthetic osteolysis remains unexplored. To enhance their in vivo application, we engineered HucMSCs-Exos-encapsulated poly lactic-co-glycolic acid (PLGA) nanoparticles (PLGA-Exos). In our study, we demonstrate that PLGA-Exos stimulate osteogenic differentiation while inhibiting the generation of reactive oxygen species (ROS) and subsequent osteoclast differentiation in vitro. In vivo imaging revealed that PLGA-Exos released exosomes slowly and maintained a therapeutic concentration. Our in vivo experiments demonstrated that PLGA-Exos effectively suppressed osteolysis induced by polyethylene particles. These findings suggest that PLGA-Exos hold potential as a therapeutic approach for the prevention and treatment of periprosthetic osteolysis. Furthermore, they provide novel insights for the clinical management of osteolysis. © 2023. The Author(s). DOI: 10.1186/s12951-023-02177-7 PMCID: PMC10617042