Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity.

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Abstract

[Indexed for MEDLINE] 13. Rom J Intern Med. 2024 Mar 23;62(1):52-60. doi: 10.2478/rjim-2023-0029. Print 2024 Mar 1. The hidden and complex relationship between dietary phosphorus and malnutrition in hemodialysis patients with chronic kidney disease. Milla C(1), Widodo(2), Wardhana TH(3). Author information: (1)Medical Programme, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. (2)Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. (3)Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. INTRODUCTION: Chronic kidney disease (CKD) has always been a complicated global challenge, ranking as the 12th leading cause of death worldwide. Hemodialysis, being one of the most opted renal replacement therapies (RRTs) for patients with end-stage renal disease (ESRD), still possesses some limitations in preventing complications, such as malnutrition and mineral bone disease (CKD-MBD). While efforts have focused on controlling CKD-MBD parameters like calcium and phosphate, less attention has been given to dietary interventions. Moreover, the adoption of low-phosphorus diets for hemodialysis patients is very complex due to potential conflicts with the guideline-recommended high-protein dietary approach. This study sought to investigate the relationship between dietary phosphorus intake and nutritional status in CKD patients undergoing regular hemodialysis. METHOD: This non-randomized cross-sectional study comprising 88 patients was conducted at the Hemodialysis Unit, RSUD Dr. Soetomo, Surabaya, East Java, using a three-day dietary record in March 2022. Relationships between variables were analyzed using Spearman and ANOVA tests. RESULT: No significant positive association was found between dietary calcium with corrected calcium levels (p = 0.988; rs = -0.002) and between dietary phosphorus with plasma phosphate levels (p = 0.082; rs = 0.187). However, Spearman's analysis revealed a weak but positive correlation between dietary phosphorus and nutritional status (p = 0.022; rs = 0.215*). CONCLUSION: Our study highlights a positive relationship between dietary phosphorus and nutritional status among hemodialysis patients, offering insights into potential strategies for optimizing patient care and outcomes. © 2024 Clonia Milla et al., published by Sciendo. DOI: 10.2478/rjim-2023-0029