Oncogenic osteomalacia due to phosphaturic mesenchymal tumour in the upper thoracic spine.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: None declared. 12. Clin Pediatr (Phila). 2023 Feb;62(2):107-114. doi: 10.1177/00099228221112461. Epub 2022 Jul 26. Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity. Segal D(1)(2), Ziv A(3)(4), Meisman A(3), Fry J(3), Altaye M(5), Gordon CM(6). Author information: (1)Division of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. (2)Division of Orthopaedic Surgery, Meir Medical Center and Tel Aviv University, Kfar Saba, Israel. (3)Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. (4)Adolescent Medicine Unit, Department of Day Care Hospitalization, Schneider Children's Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel. (5)Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. (6)Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA. Adolescents with overweight/obesity are at risk for vitamin D insufficiency and deficiency. Both overweight/obesity and vitamin D insufficiency/deficiency may predispose to fractures. We enrolled 103 participants (53.3% females, 15.9 ± 2.2 years) in a retrospective case-control study to determine whether an association exists between fractures and a low 25-hydroxyvitamin D (25[OH]D) among adolescents whose body mass index (BMI) ≥ 85 percentile. Cases (n = 28) sustaining a low/medium impact fracture were matched to controls (n = 75) without a fracture history. A conditional-logistic regression analysis addressing the common vitamin D insufficiency/deficiency cutoffs was used. Overweight, obesity, and significant obesity rates were 10.7%, 53.4%, and 35.9%, respectively. Mean (±SD) 25(OH)D was 16.5 ± 6.4 ng/mL. In all, 25(OH)D insufficiency rates (level .05). Controlling for race and seasonality showed no association between fractures and 25(OH)D insufficiency/deficiency (P > .05). These data suggest that fractures are not associated with low 25(OH)D levels among adolescents whose BMI ≥ 85th percentile. DOI: 10.1177/00099228221112461