Discovery of a highly specific radiolabeled antibody targeting B-cell maturation antigen: Applications in PET imaging of multiple myeloma.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Conflicts of interest: The authors declare no conflicts of interest. 17. Diagn Pathol. 2015 Jul 9;10:91. doi: 10.1186/s13000-015-0318-9. Rapid recurrence and bilateral lungs, multiple bone metastasis of malignant solitary fibrous tumor of the right occipital lobe: report of a case and review. Wu Z(1), Yang H(2), Weng D(3), Ding Y(4). Author information: (1)Department of Pathology, School of Basic Medical Sciences; Department of Pathology, Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China. wuzr813@163.com. (2)Department of Pathology, School of Basic Medical Sciences; Department of Pathology, Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China. pathyang@smu.edu.cn. (3)State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. wengdsh@sysucc.org.cn. (4)Department of Pathology, School of Basic Medical Sciences; Department of Pathology, Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China. dyq@fimmu.com. BACKGROUND: Intracranial malignant solitary fibrous tumor (MSFT) is extremely rare. The authors report a case of MSFT of the right occipital lobe with a rapid recurrence and bilateral lung, multiple bone metastasis. CASE PRESENTATION: The patient was a 25-year-old male presenting with headache, nausea and visual disturbances without obvious cause. Three times right-side occipital craniotomies were performed and two times postoperative conformal radiotherapy were administered within one year. 4 months after the third time of right-side occipital craniotomy, the patient felt right chest pain and neck pain. Positron emission tomography/computed tomography (PET/CT) showed tumor recurrence of the right occipital lobe and bilateral lung metastasis, multiple bone metastasis including: vertebrae, libs, the left iliac wing, sacrum, the right ischium and upper parts of both femurs. Ultrasound guided puncture biopsy of left-side back of the neck and CT guided puncture biopsy of the third lumbar vertebra were performed. General sample showed grayish white or grayish red with irregular shape. Histopathologically, the tumor was composed of areas of alternating hypercellularity and hypocellularity with spindle-shaped cells, which arranged as fascicular, storiform pattern or patternless pattern, with intervening irregular eosinophilic collagen bundles. Some areas showed hemangiopericytoma-like perivascular pattern and perivascular hyalinization. Tumor cells were pleomorphic with mitotic counts of more than 4 per 10 high power fields and showed coagulative necrosis. Immunohistochemically, tumor cells were diffusely positive for vimentin and CD99, focal positive for CD34, bcl-2 and Actin. Ki-67 labelling index was more than 40%. The final pathological diagnosis was MSFT of the right occipital lobe, metastatic MSFT of left-side back of the neck and the third lumbar vertebra. CONCLUSION: The MSFT of the right occipital lobe with recurrence and bilateral lung, multiple bone metastasis is extremely rare. Although intracranial MSFT is extremely rare, it should be considered in the differential diagnosis. Definite diagnosis depended mainly on pathological morphology and immunohistochemistry. The prognosis of MSFT is poor due to recurrence and metastasis. Complete resection of intracranial MSFT is difficult, and carful follow-up is needed. DOI: 10.1186/s13000-015-0318-9 PMCID: PMC4495700