Current developments in orthopaedic implant technology.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Declaration of generative AI and AI-assisted technologies in the writing process: During the preparation of this work the authors used ChatGPT-4, developed by OpenAI (San Francisco, California, USA), to address language related errors. After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. Conflict of interest: The author, his immediate family, and any research foundation with which they are affiliated did not receive any financial payments or other benefits from any commercial entity related to the subject of this article. 8. Expert Rev Med Devices. 2007 Jan;4(1):55-64. doi: 10.1586/17434440.4.1.55. Selfprotective smart orthopedic implants. Parvizi J(1), Antoci V Jr, Hickok NJ, Shapiro IM. Author information: (1)Thomas Jefferson University, Rothman Institute of Orthopedics, 925 Chestnut Street, Philadelphia, PA 19107, USA. parvj@aol.com In this review, we discuss current advances leading to an exciting change in implant design for orthopedic surgery. The initial biomaterial approaches in implant design are being replaced by cellular-molecular interactions and nanoscale chemistry. New designs address implant complications, particularly loosening and infection. For infection, local delivery systems are an important first step in the process. Selfprotective 'smart' devices are an example of the next generation of orthopedic implants. If proven to be effective, antibiotics or other active molecules that are tethered to the implant surface through a permanent covalent bond and tethering of antibiotics or other biofactors are likely to transform the practice of orthopedic surgery and other medical specialties. This new technology has the potential to eliminate periprosthetic infection, a major and growing problem in orthopedic practice. DOI: 10.1586/17434440.4.1.55