Harnessing 4D Printing Bioscaffolds for Advanced Orthopedics.

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Abstract

[Indexed for MEDLINE] 10. J Orthop Res. 2023 Mar;41(3):601-613. doi: 10.1002/jor.25388. Epub 2022 Jun 9. The presence of 3D printing in orthopedics: A clinical and material review. Rodriguez Colon R(1)(2), Nayak VV(3)(4), Parente PEL(5)(6), Leucht P(6)(7), Tovar N(3), Lin CC(6), Rezzadeh K(6), Hacquebord JH(2)(6), Coelho PG(2)(3)(4), Witek L(3)(8). Author information: (1)Icahn School of Medicine at Mount Sinai, New York, New York, USA. (2)Hansjörg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, New York, USA. (3)Biomaterials Division - Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA. (4)Department of Mechanical and Aerospace Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA. (5)Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA. (6)Department of Orthopedic Surgery, NYU Grossman School of Medicine, New York, New York, USA. (7)Department of Cell Biology, NYU Grossman School of Medicine, New York, New York, USA. (8)Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA. The field of additive manufacturing, 3D printing (3DP), has experienced an exponential growth over the past four decades, in part due to increased accessibility. Developments including computer-aided design and manufacturing, incorporation of more versatile materials, and improved printing techniques/equipment have stimulated growth of 3DP technologies within various industries, but most specifically the medical field. Alternatives to metals including ceramics and polymers have been garnering popularity due to their resorbable properties and physiologic similarity to extracellular matrix. 3DP has the capacity to utilize an assortment of materials and printing techniques for a multitude of indications, each with their own associated benefits. Within the field of medicine, advances in medical imaging have facilitated the integration of 3DP. In particular, the field of orthopedics has been one of the earliest medical specialties to implement 3DP. Current indications include education for patients, providers, and trainees, in addition to surgical planning. Moreover, further possibilities within orthopedic surgery continue to be explored, including the development of patient-specific implants. This review aims to highlight the use of current 3DP technology and materials by the orthopedic community, and includes comments on current trends and future direction(s) within the field. © 2022 Orthopaedic Research Society. Published by Wiley Periodicals LLC. DOI: 10.1002/jor.25388