Consensus on Implants in Infections After Spine Surgery.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] 14. Biomed Mater. 2020 Nov 21;15(6):062001. doi: 10.1088/1748-605X/aba446. Emerging local delivery strategies to enhance bone regeneration. Elangovan S(1), Gajendrareddy P(2), Ravindran S(3), Salem AK(4). Author information: (1)Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, IA 52242, United States of America. (2)Department of Periodontics, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America. (3)Department of Oral Biology, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America. (4)Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, IA 52242, United States of America. In orthopedics and dentistry there is an increasing need for novel biomaterials and clinical strategies to achieve predictable bone regeneration. These novel molecular strategies have the potential to eliminate the limitations of currently available approaches. Specifically, they have the potential to reduce or eliminate the need to harvest autogenous bone, and the overall complexity of the clinical procedures. In this review, emerging tissue engineering strategies that have been, or are currently being, developed based on the current understanding of bone biology, development and wound healing will be discussed. In particular, protein/peptide based approaches, DNA/RNA therapeutics, cell therapy, and the use of exosomes will be briefly covered. The review ends with a summary of the current status of these approaches, their clinical translational potentials and their challenges. DOI: 10.1088/1748-605X/aba446 PMCID: PMC10148649