Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. 18. Adv Healthc Mater. 2023 Apr;12(10):e2202591. doi: 10.1002/adhm.202202591. Epub 2023 Feb 5. Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications. Locke RC(1)(2), Zlotnick HM(1)(2)(3), Stoeckl BD(1)(2)(3), Fryhofer GW(1), Galarraga JH(3), Dhand AP(3), Zgonis MH(1), Carey JL(1), Burdick JA(4)(5), Mauck RL(1)(2)(3). Author information: (1)Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA. (2)Department of Veterans Affairs, CMCVAMC, Philadelphia, PA, 19104, USA. (3)Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. (4)Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, 80303, USA. (5)BioFrontiers Institute, University of Colorado, Boulder, CO, 80303, USA. The expanse of publications in tissue engineering (TE) and orthopedic TE (OTE) over the past 20 years presents an opportunity to probe emergent trends in the field to better guide future technologies that can make an impact on musculoskeletal therapies. Leveraging this trove of knowledge, a hierarchical systematic search method and trend analysis using connected network mapping of key terms is developed. Within discrete time intervals, an accelerated publication rate for anatomic orthopedic tissue engineering (AOTE) of osteochondral defects, tendons, menisci, and entheses is identified. Within these growing fields, the top-listed key terms are extracted and stratified into evident categories, such as biomaterials, delivery method, or 3D printing and biofabrication. It is then identified which categories decreased, remained constant, increased, or emerged over time, identifying the specific emergent categories currently driving innovation in orthopedic repair technologies. Together, these data demonstrate a significant convergence of material types and descriptors used across tissue types. From this convergence, design criteria to support future research of anatomic constructs that mimic both the form and function of native tissues are formulated. In summary, this review identifies large-scale trends and predicts new directions in orthopedics that will define future materials and technologies. © 2023 Wiley-VCH GmbH. DOI: 10.1002/adhm.202202591 PMCID: PMC10121863