Adverse Events Following Minimally Invasive Achilles Tendon Repair.

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Abstract

[Indexed for MEDLINE] 8. Adv Healthc Mater. 2024 Oct;13(26):e2400968. doi: 10.1002/adhm.202400968. Epub 2024 May 11. A Mesoporous Silica-Loaded Multi-Functional Hydrogel Enhanced Tendon Healing via Immunomodulatory and Pro-Regenerative Effects. Wan R(1), Luo Z(1), Nie X(2)(3), Feng X(1), He Y(1), Li F(4), Liu S(4), Chen W(1), Qi B(5), Qin H(6), Luo W(1), Zhang H(1), Jiang H(7), Sun J(8), Liu X(2)(3), Wang Q(9), Shang X(1), Qiu J(2)(3), Chen S(1). Author information: (1)Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. (2)State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China. (3)Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China. (4)Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, 200040, China. (5)Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No.2800 GongWei road, Shanghai, 200100, China. (6)Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, Shanghai, 200040, China. (7)Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, China. (8)Laboratory Animal Center, Guangxi Medical University, Zhuang Autonomous Region, Nanning, Guangxi, 530021, China. (9)Department of Orthopaedics, Kunshan Hospital of Traditional Chinese Medicine, No. 388 Zu Chong Zhi Road, Kunshan, Jiangsu, 215300, China. Tendon injuries are pervasive orthopedic injuries encountered by the general population. Nonetheless, recovery after severe injuries, such as Achilles tendon injury, is limited. Consequently, there is a pressing need to devise interventions, including biomaterials, that foster tendon healing. Regrettably, tissue engineering treatments have faced obstacles in crafting appropriate tissue scaffolds and efficacious nanomedical approaches. To surmount these hurdles, an innovative injectable hydrogel (CP@SiO2), comprising puerarin and chitosan through in situ self-assembly, is pioneered while concurrently delivering mesoporous silica nanoparticles for tendon healing. In this research, CP@SiO2 hydrogel is employed for the treatment of Achilles tendon injuries, conducting extensive in vivo and in vitro experiments to evaluate its efficacy. This reults demonstrates that CP@SiO2 hydrogel enhances the proliferation and differentiation of tendon-derived stem cells, and mitigates inflammation through the modulation of macrophage polarization. Furthermore, using histological and behavioral analyses, it is found that CP@SiO2 hydrogel can improve the histological and biomechanical properties of injured tendons. This findings indicate that this multifaceted injectable CP@SiO2 hydrogel constitutes a suitable bioactive material for tendon repair and presents a promising new strategy for the clinical management of tendon injuries. © 2024 Wiley‐VCH GmbH. DOI: 10.1002/adhm.202400968