Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: This review does not require ethical review at this time. Consent for publication: All participants have given their consent for their data and personal information to be used for the publication of this study and all personal information involved has been anonymized to ensure privacy. Competing interests: All authors report no conflicts of interest. 19. Med Sci Monit. 2023 Sep 16;29:e940805. doi: 10.12659/MSM.940805. A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration. Chen J(1), Jiang C(1), Yin L(1), Liu Y(2), He Y(3), Li S(4), Shen H(1). Author information: (1)Department of Joint Surgery, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland). (2)School of Materials and Energy, Southwest University; Southwest University Hospital, Chongqing, China (mainland). (3)Sichuan Provincial Ba-Yi Rehabilitation Center (Sichuan Provincial Rehabilitation Hospital), Chengdu, Sichuan, China (mainland). (4)Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing, Jiangsu, China (mainland). Tendon-bone injuries are a prevalent health concern associated with sports and other physically demanding activities. These injuries have a limited innate healing ability, often leading to the formation of scar tissue rather than the regeneration of healthy tendon tissue. This scar tissue results from excessive fibrosis during the early healing process and often leads to reduced tendon function and an increased risk of reinjury. Traditionally, surgical reconstruction has been the primary treatment for tendon-bone injuries. However, restoring the natural structure and mechanical properties of tendons after surgical reconstruction presents a considerable challenge. Recently, the potential of stem cell therapy has been explored as an alternative treatment approach. In particular, a new type of pluripotent stem cell known as tendon stem cells (TDSCs) has been identified within tendon tissue. These cells exhibit the potential for self-renewal and multidirectional differentiation, meaning they can differentiate into fibroblasts and chondrocytes. These differentiated cells can aid in the repair and regeneration of new tissues by producing collagen and other matrix molecules that provide structural support. TDSCs have become a focal point in research for treating tendon-bone injuries and related conditions. The potential use of these cells provides a basis for both basic research and clinical applications, particularly in understanding the tendon-bone healing process and identifying factors that affect the ability of TDSCs to promote this healing. This review article aims to analyze the role of TDSCs in tendon-bone healing, understanding their therapeutic potential and contributing to the development of effective treatment strategies for tendon-bone injuries. DOI: 10.12659/MSM.940805 PMCID: PMC10508086