Human nonunion tissues display differential gene expression in comparison to physiological fracture callus.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest None. 16. Materials (Basel). 2023 Aug 30;16(17):5958. doi: 10.3390/ma16175958. Stability Analysis of Plate-Screw Fixation for Femoral Midshaft Fractures. Basirom I(1), Daud R(1), Ijaz MF(2), Rojan MA(1), Basaruddin KS(1). Author information: (1)Fracture and Damage Mechanics (FDM), Faculty of Mechanical Engineering Technology, University Malaysia Perlis, Arau 02600, Perlis, Malaysia. (2)Mechanical Engineering Department, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia. An understanding of the biomechanical characteristics and configuration of flexible and locked plating in order to provide balance stability and flexibility of implant fixation will help to construct and promote fast bone healing. The relationship between applied loading and implantation configuration for best bone healing is still under debate. This study aims to investigate the relationship between implant strength, working length, and interfragmentary strain (εIFM) on implant stability for femoral midshaft transverse fractures. The transverse fracture was fixed with a fragment locking compression plate (LCP) system. Finite element analysis was performed and subsequently characterised based on compression loading (600 N up to 900 N) and screw designs (conventional and locking) with different penetration depths (unicortical and bicortical). Strain theory was used to evaluate the stability of the model. The correlation of screw configuration with screw type shows a unicortical depth for both types (p < 0.01) for 700 N and 800 N loads and (p < 0.05) for configurations 134 and 124. Interfragmentary strain affected only the 600 N load (p < 0.01) for the bicortical conventional type (group BC), and the screw configurations that were influenced were 1234 and 123 (p < 0.05). The low steepness of the slope indicates the least εIFM for the corresponding biomechanical characteristic in good-quality stability. A strain value of ≤2% promotes callus formation and is classified as absolute stability, which is the minimum required value for the induction of callus and the maximum value that allows bony bridging. The outcomes have provided the correlation of screw configuration in femoral midshaft transverse fracture implantation which is important to promote essential primary stability. DOI: 10.3390/ma16175958 PMCID: PMC10489176