[Benefits of radiotherapy for patients with solitary plasmacytoma or multiple myeloma].

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Abstract

[Indexed for MEDLINE] 11. Cancer Rep (Hoboken). 2025 Aug;8(8):e70299. doi: 10.1002/cnr2.70299. Population-Based Survival Analysis of Solitary Plasmacytoma of Spine in the United States From 2000 to 2020. Agner KE(1), Comisford LG(1), Kotler AG(1), Wells JA(1), Larkins MC(2). Author information: (1)The Ohio State University College of Medicine, Columbus, Ohio, USA. (2)Department of Emergency Medicine, Boonshoft School of Medicine at Wright State University, Fairborn, Ohio, USA. BACKGROUND: Solitary plasmacytomas of bone of the spine (SPBS) are rare tumors associated with significant morbidity and mortality, especially with progression to multiple myeloma. AIMS: While demographic and treatment factors influencing survival have been investigated in previous studies, analysis using the most recent population data and assessing more granular data such as the extent of surgical resection in conjunction with radiotherapy has yet to be performed. METHODS: The Surveillance, Epidemiology, and End Results (SEER) Program was queried for patients with a diagnosis of SPBS (ICD-0-3 code 9731/3). Demographic and treatment variables were analyzed using Cox regression, and a log-rank analysis was used to assess 5-year overall survival (5y OS). RESULTS: A total of 1391 patients diagnosed with localized SPBS were identified. Multivariate analysis revealed that increasing age at diagnosis (HR = 2.25, p