Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: No potential conflict of interest was reported. 15. Osteoporos Int. 2023 May;34(5):999-1003. doi: 10.1007/s00198-023-06669-y. Epub 2023 Jan 14. DXA-based bone strain index in normocalcemic primary hyperparathyroidism. Tabacco G(#)(1)(2), Naciu AM(#)(3)(4), Messina C(5)(6), Sanson G(7), Rinaudo L(8), Cesareo R(9), Falcone S(10), Napoli N(3)(4), Ulivieri FM(11), Palermo A(3)(4). Author information: (1)Unit of Metabolic Bone and Thyroid Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. g.tabacco@policlinicocampus.it. (2)Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy. g.tabacco@policlinicocampus.it. (3)Unit of Metabolic Bone and Thyroid Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. (4)Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy. (5)IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. (6)Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy. (7)School of Nursing, Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. (8)Tecnologie Avanzate, Torino, Italy. (9)UOS Malattie Metaboliche, Santa Maria Goretti Hospital, Latina, Italy. (10)Unit of Endocrinology and Metabolic Diseases, CTO A. Alesini Hospital, University Tor Vergata, Rome, Italy. (11)Bone Metabolic Unit, Casa di Cura la Madonnina, Milano, Italy. (#)Contributed equally The trabecular and cortical bone assessed by bone strain index seems not to be significantly affected in NHPT. INTRODUCTION: The natural history and bone involvement of normocalcemic hyperparathyroidism (NHPT) are not fully clarified yet. The bone strain index (BSI) is a deformation index based on the finite element method and can be applied to DXA scans. In this study, we aim to assess BSI in subjects with NHPT. METHOD: A case-control study included 170 subjects: 40 subjects with NHPT, 50 subjects with primary hypercalcemic hyperparathyroidism (PHPT), and 80 controls (age- and sex-matched with the NPTH group). RESULTS: Lumbar spine (LS) bone mineral density (BMD), femoral neck (FN) BMD, total hip (TH) BMD, and TBS were similar between NHPT and both PHPT and controls. FN-BSI was lower in NHPT compared to PHPT (1.52 ± 0.31 vs 1.72 ± 0.42 p = 0.031) while there were no differences between NHPT and controls. TH-BSI was lower in NHPT compared to PHPT (1.36 ± 0.23 vs 1.52 ± 0.34, p = 0.030), while there were no differences between NHPT and controls. LS-BSI was not different between NHPT and both PHPT and controls. CONCLUSION: The trabecular and cortical bones assessed by BSI seem not to be significantly impaired in NHPT. Further prospective studies are needed to confirm these findings and to give an insight into the natural history of NHPT to improve knowledge and management of this condition. © 2023. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation. DOI: 10.1007/s00198-023-06669-y