Paget's disease of bone: A clinical update.

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Abstract

[Indexed for MEDLINE] 19. J Bone Miner Res. 2006 Dec;21 Suppl 2:P58-63. doi: 10.1359/jbmr.06s211. Osteosarcoma in Paget's disease of bone. Hansen MF(1), Seton M, Merchant A. Author information: (1)Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. mhansen@nso2.uchc.edu Paget's disease of bone (PDB) is a focal disorder of bone metabolism first described by Sir James Paget in 1876. It is presumed benign in nature and mediated by abnormal osteoclast function. The incidence of osteosarcomas complicating PDB is estimated at