Evidence Search

Periprosthetic osteolysis: Mechanisms and potential treatment strategies.

Cellular signalling | 2025 | Yao F, Bao Y, Meng Q, Chen Y

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. 16. Clin Orthop Relat Res. 2005 Jan;(430):39-45. doi: 10.1097/01.blo.0000149998.88218.05. Pharmacologic modulation of pe...

A review of wear debris in thumb base joint implants.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2024 | Mangan F, Spece H, Weiss AC, Ladd AL

[Indexed for MEDLINE] 8. Orthopadie (Heidelb). 2023 Mar;52(3):214-221. doi: 10.1007/s00132-023-04349-7. Epub 2023 Feb 23. Hypersensitivity and lymphocyte activation after total hip arthroplasty. [Article in English] Costa MD(1)(2), Donner S(3), Bertrand J(1), Pop OL(2), Lohmann CH(4). Author information: (1)Department of Orthopaedic Surgery, Otto-von-Guericke University, Leipzi...

Hypersensitivity and lymphocyte activation after total hip arthroplasty.

Orthopadie (Heidelberg, Germany) | 2023 | Costa MD, Donner S, Bertrand J, Pop OL

[Indexed for MEDLINE] 9. Clin Orthop Relat Res. 2007 Jul;460:240-52. doi: 10.1097/BLO.0b013e31804b4147. The biology of aseptic osteolysis. Holt G(1), Murnaghan C, Reilly J, Meek RM. Author information: (1)Department of Orthopaedic and Trauma Surgery, Southern General Hospital, Glasgow, Scotland, UK. Total hip arthroplasty is one of the most commonly performed and successful ele...

Ortho Plastics The Adoption and Evolution of Polyethylene in Orthopedic Surgery.

Bulletin of the Hospital for Joint Disease (2013) | 2023 | Feder O, Lawrence KW, Driesman A, Schwarzkopf R

[Indexed for MEDLINE] 15. Cell Signal. 2025 Jul;131:111758. doi: 10.1016/j.cellsig.2025.111758. Epub 2025 Mar 23. Periprosthetic osteolysis: Mechanisms and potential treatment strategies. Yao F(1), Bao Y(2), Meng Q(3), Chen Y(4), Zhao L(5), Wang P(6), Zhou B(7). Author information: (1)Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Shandong Univ...

Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis.

Current osteoporosis reports | 2022 | Goodman SB, Gibon E, Gallo J, Takagi M

[Indexed for MEDLINE] 7. Eur J Orthop Surg Traumatol. 2024 Jan;34(1):251-269. doi: 10.1007/s00590-023-03622-x. Epub 2023 Jul 13. A review of wear debris in thumb base joint implants. Mangan F(1), Spece H(2)(3), Weiss AC(4), Ladd AL(5), Stockmans F(6), Kurtz SM(2)(3). Author information: (1)Loci Orthopaedics, Galway, Ireland. fiona@lociorthopaedics.com. (2)Drexel University, Phi...

Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty.

Journal of biomedical materials research. Part B, Applied biomaterials | 2020 | Hameister R, Kaur C, Dheen ST, Lohmann CH

[Indexed for MEDLINE] 12. Acta Biomed. 2017 Jun 7;88(2S):98-111. doi: 10.23750/abm.v88i2-S.6520. Management of metaphyseal bone loss in revision knee arthroplasty. Mancuso F(1), Beltrame A, Colombo E, Miani E, Bassini F. Author information: (1). fra.mancuso@gmail.com. BACKGROUND AND AIM OF THE WORK: Revision total knee arthroplasty (TKA) is usually made more complex by the pres...

Isolated Head and Liner Exchange in Revision Hip Arthroplasty.

The Journal of the American Academy of Orthopaedic Surgeons | 2017 | Walmsley DW, Waddell JP, Schemitsch EH

[Indexed for MEDLINE] 5. Mil Med Res. 2022 Aug 23;9(1):46. doi: 10.1186/s40779-022-00404-0. Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles. Wu YL(#)(1)(2), Zhang CH(#)(1), Teng Y(2), Pan Y(3), Liu NC(2), Liu PX(2), Zhu X(2), Su XL(2), Lin J(4). Author information: (1)Department of Orthopaedics, Suzhou Dushu Lake...

Management of metaphyseal bone loss in revision knee arthroplasty.

Acta bio-medica : Atenei Parmensis | 2017 | Mancuso F, Beltrame A, Colombo E, Miani E

[Indexed for MEDLINE] 13. Radiographics. 2015 Sep-Oct;35(5):1483-501. doi: 10.1148/rg.2015140216. Epub 2015 Aug 21. MR Imaging of Knee Arthroplasty Implants. Fritz J(1), Lurie B(1), Potter HG(1). Author information: (1)From the Department of Radiology and Imaging, Hospital for Special Surgery, 535 E 70th St, New York, NY 10021. Primary total knee arthroplasty is a highly effect...

Wear products of total hip arthroplasty: The case of polyethylene.

Morphologie : bulletin de l'Association des anatomistes | 2017 | Massin P, Achour S

[Indexed for MEDLINE]

MR Imaging of Knee Arthroplasty Implants.

Radiographics : a review publication of the Radiological Society of North America, Inc | 2015 | Fritz J, Lurie B, Potter HG

[Indexed for MEDLINE] 14. Bull Hosp Jt Dis (2013). 2023 Mar;81(1):78-83. Ortho Plastics The Adoption and Evolution of Polyethylene in Orthopedic Surgery. Feder O, Lawrence KW, Driesman A, Schwarzkopf R, Aggarwal V, Rozell J. Total joint arthroplasty relies on the use of biomaterials that are biologically inert and capable of forming wear-resistant articulating surfaces. Polyeth...

Emerging applications of proteomics in hip and knee arthroplasty.

Expert review of proteomics | 2014 | Cooper HJ

[Indexed for MEDLINE] 2. J Bone Joint Surg Br. 2012 Jan;94(1):10-5. doi: 10.1302/0301-620X.94B1.28047. Current concepts in osteolysis. Ollivere B(1), Wimhurst JA, Clark IM, Donell ST. Author information: (1)Norfolk & Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK. ben.ollivere@nuh.nhs.uk The most frequent cause of failure after total hip replacement in all report...

Current concepts in osteolysis.

The Journal of bone and joint surgery. British volume | 2012 | Ollivere B, Wimhurst JA, Clark IM, Donell ST

[Indexed for MEDLINE] 3. Mol Med. 2024 Dec 20;30(1):266. doi: 10.1186/s10020-024-01034-z. Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade. Yu X(#)(1), Jiang J(#)(2), Li C(#)(1), Wang Y(#)(1), Ren Z(2), Hu J(3), Yuan T(1), Wu Y(2), Wang D(4), Sun Z(1), Wu Q(5), Chen B(6), Fang P(1), Ding H(1),...

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.

Molecular medicine (Cambridge, Mass.) | 2024 | Yu X, Jiang J, Li C, Wang Y

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: All experimental protocols were approved by the Ethical Committee of Nanjing Jinling Hospital, the Affiliated Hospital of Nanjing University Medical School. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. 4. J...

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy.

Journal of nanobiotechnology | 2024 | Liu X, Wang W, Zhu F, Xu H

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: Clinical samples were collected with permission of the Ethics Committee of the First Affiliated Hospital of Soochow University. All animal experiments were approved by the Ethics Committee of Soochow University. Consent for publication: All authors agree to be publish...

Polyethylene Wear and Osteolysis

Advances in Total Hip Arthroplasty | 2024 | Yuya Takakubo, Michiaki Takagi

Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles.

Military Medical Research | 2022 | Wu YL, Zhang CH, Teng Y, Pan Y

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no competing interests. 6. Curr Osteoporos Rep. 2022 Feb;20(1):43-52. doi: 10.1007/s11914-022-00720-3. Epub 2022 Feb 8. Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis. Goodman SB(1), Gibon E(2), Gallo J(3), Takagi M(4). Author information: (1)Departments of Ort...

The biology of aseptic osteolysis.

Clinical orthopaedics and related research | 2007 | Holt G, Murnaghan C, Reilly J, Meek RM

[Indexed for MEDLINE] 10. JBJS Rev. 2016 Jul 5;4(7):e1. doi: 10.2106/JBJS.RVW.15.00081. Osteolysis Complicating Total Knee Arthroplasty. Gilbert TJ(1), Anoushiravani AA, Sayeed Z, Chambers MC, El-Othmani MM, Saleh KJ. Author information: (1)Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois....

Pharmacologic modulation of periprosthetic osteolysis.

Clinical orthopaedics and related research | 2005 | Goodman SB, Trindade M, Ma T, Genovese M

[Indexed for MEDLINE] 17. Acta Orthop Belg. 1999 Jun;65(2):154-63. Femoral bone loss in total knee arthroplasty. A review. van Loon CJ(1), de Waal Malefijt MC, Buma P, Verdonschot N, Veth RP. Author information: (1)Department of Orthopedics, University Hospital Nijmegen, The Netherlands. Femoral bone loss in total knee arthroplasty (TKA) is a common feature and is mainly attrib...

Particle bioreactivity and wear-mediated osteolysis.

The Journal of arthroplasty | 2004 | Wang ML, Sharkey PF, Tuan RS

[Indexed for MEDLINE] 20. Morphologie. 2017 Mar;101(332):1-8. doi: 10.1016/j.morpho.2016.06.001. Epub 2016 Jul 15. Wear products of total hip arthroplasty: The case of polyethylene. Massin P(1), Achour S(2). Author information: (1)Département de chirurgie orthopédique, hôpitaux universitaires Paris Nord Val-de-Seine, site Beaujon, 100, boulevard du General-Leclerc, 92110 Clichy...

Osteolysis as it Pertains to Total Hip Arthroplasty

Orthopedic Clinics of North America | 2018 | Brian Kurcz, Joseph Lyons, Zain Sayeed, Afshin A. Anoushiravani

Wear and Osteolysis of Polyethylene Bearings

Complications after Primary Total Hip Arthroplasty | 2017 | James A. Keeney

Osteolysis Complicating Total Knee Arthroplasty.

JBJS reviews | 2016 | Gilbert TJ, Anoushiravani AA, Sayeed Z, Chambers MC

[Indexed for MEDLINE] 11. J Biomed Mater Res B Appl Biomater. 2020 Jul;108(5):2073-2087. doi: 10.1002/jbm.b.34546. Epub 2020 Jan 2. Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty. Hameister R(1), Kaur C(1), Dheen ST(1), Lohmann CH(2), Singh G(3). Author information: (1)Department of Anatomy, Yong Loo Lin School of Medicine, National University o...

Review Article: Polyethylene Wear and Osteolysis in Total Hip Arthroplasty

Journal of Orthopaedic Surgery | 2001 | YH Zhu, KY Chiu, WM Tang

Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent follow-up. Polyethyle...

Femoral bone loss in total knee arthroplasty. A review.

Acta orthopaedica Belgica | 1999 | van Loon CJ, de Waal Malefijt MC, Buma P, Verdonschot N

[Indexed for MEDLINE] 18. J Nanobiotechnology. 2024 Dec 18;22(1):758. doi: 10.1186/s12951-024-03049-4. Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy. Liu X(#)(1), Wang W(#)(1), Zhu F(#)(1), Xu H(1), Ge G(1), Liang X(1), Yang H(1), Xu Y(1), Xu W(2), Wei M(3), Zhou Q(4), Geng D(5). Author information: (1)Dep...

Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation

Journal of Orthopaedic Research | 2013 | Lyndsey Burton, Daniel Paget, Nikolaus B. Binder, Krista Bohnert

AbstractActivation of myeloid cells by orthopedic particulate debris is a key event in the pathogenesis of periprosthetic osteolysis and implant loosening after total joint replacement (TJR). Several lines of evidence implicate NACHT, LRR, and PYD domains‐containing protein 3 (NALP3) inflammasome‐mediated production of interleukin 1 beta (IL‐1β) in the pathogenesis of clinical...

Thigh mass associated with polyethylene wear-induced osteolysis after cementless total hip arthroplasty

Archives of Orthopaedic and Trauma Surgery | 2010 | Youn-Soo Park, Seung-Jae Lim, Jin-Hong Kim, Ajay Wala

Wear particles and osteolysis

Orthopaedic Bone Cements | 2008 | N. PATIL, S.B. GOODMAN

What patient and surgical factors contribute to implant wear and osteolysis in total joint arthroplasty?

Journal of the American Academy of Orthopaedic Surgeons | 2008 | Audrey K. Tsao, Lynne C. Jones, David G. Lewallen

How prevalent are implant wear and osteolysis, and how has the scope of osteolysis changed since 2000?

Journal of the American Academy of Orthopaedic Surgeons | 2008 | Amanda Marshall, Michael D. Ries, Wayne Paprosky

Wear and Osteolysis Around Total Knee Arthroplasty

Journal of the American Academy of Orthopaedic Surgeons | 2007 | Douglas D.R. Naudie, Deborah J. Ammeen, Gerard A. Engh, Cecil H. Rorabeck

Wear particulate and osteolysis

Orthopedic Clinics of North America | 2005 | Stuart Goodman

Wear and Osteolysis in Total Hip Arthroplasty

Seminars in Arthroplasty | 2005 | Kevin J. Bozic, Michael D. Ries

Characteristics of Wear Particles and Osteolysis

Joint Arthroplasty | 1999 | Hirotsugu Ohashi, Yoshinori Kadoya, Akio Kobayashi, Hiroyoshi Iwaki

Effect of polyethylene wear on osteolysis in cementless primary total hip arthroplasty

The Journal of Arthroplasty | 1999 | Chang-Dong Han, Wahn-Sub Choe, Ju-Hyung Yoo