Orthonotes
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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Types of Callus in Fracture Healing
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
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PubMed Narrative Review Evidence Moderate

Experimental agents to improve fracture healing: utilizing the WNT signaling pathway.

Injury | 2021 | Haffner-Luntzer M

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Competing Interest I hereby declare that I have no conflict of interest regarding this manuscript. 10. Bone. 2020 Aug;137:115403. doi: 10.1016/j.bone.2020.115403. Epub 2020 May 1. What do we know about bone morphogenetic proteins and osteochondroprogenitors in inflammatory conditions? Lukač N(1), Katavić V(1),...

PubMed Narrative Review Evidence Moderate

What do we know about bone morphogenetic proteins and osteochondroprogenitors in inflammatory conditions?

Bone | 2020 | Lukač N, Katavić V, Novak S, Šućur A

[Indexed for MEDLINE] 11. Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):384-98. doi: 10.1016/j.pbiomolbio.2006.07.021. Epub 2006 Aug 10. The enhancement of bone regeneration by ultrasound. Claes L(1), Willie B. Author information: (1)Institute for Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany. lutz.claes@uni-ulm.de Millions of f...

PubMed Narrative Review Evidence Moderate

Quantitative phenotyping of bone fracture repair: a review.

BoneKEy reports | 2014 | Casanova M, Schindeler A, Little D, Müller R

Conflict of interest statement: The authors declare no conflict of interest. 9. Injury. 2021 Jun;52 Suppl 2:S44-S48. doi: 10.1016/j.injury.2020.11.051. Epub 2020 Nov 18. Experimental agents to improve fracture healing: utilizing the WNT signaling pathway. Haffner-Luntzer M(1). Author information: (1)Institute of Orthopedic Research and Biomechanics, University Medical Center Ul...

PubMed Original Article Evidence Unclassified

Effects of aging on the immune and periosteal response to fracture injury.

Bone | 2025 | King JS, Wan M, Kim A, Prabhu S

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest All authors report no conflicts of interest. 4. Br J Sports Med. 1996 Jun;30(2):171-5. doi: 10.1136/bjsm.30.2.171. The footballer's fracture. Cattermole HR(1), Hardy JR, Gregg PJ. Author information: (1)Department of Orthopaedic Surgery, Hospital of St Cross, Rugby, United Kingdom. Erratum i...

PubMed Original Article Evidence Unclassified

Targeting senescent cells to boost bone fracture healing.

The Journal of clinical investigation | 2024 | Hofbauer LC, Baschant U, Hofbauer C

[Indexed for MEDLINE] Conflict of interest statement: Conflict of interest: The authors have declared that no conflict of interest exists. 3. Bone. 2025 Sep;198:117524. doi: 10.1016/j.bone.2025.117524. Epub 2025 May 15. Effects of aging on the immune and periosteal response to fracture injury. King JS(1), Wan M(1), Kim A(2), Prabhu S(1), Novak S(3), Kalajzic I(3), Delany AM(4),...

PubMed Original Article Evidence Unclassified

Human nonunion tissues display differential gene expression in comparison to physiological fracture callus.

Bone | 2024 | Salichos L, Thayavally R, Kloen P, Hadjiargyrou M

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest None. 16. Materials (Basel). 2023 Aug 30;16(17):5958. doi: 10.3390/ma16175958. Stability Analysis of Plate-Screw Fixation for Femoral Midshaft Fractures. Basirom I(1), Daud R(1), Ijaz MF(2), Rojan MA(1), Basaruddin KS(1). Author information: (1)Fracture and Damage Mechanics (FDM), Faculty of...

PubMed Original Article Evidence Unclassified

The Role of Botulinum Neurotoxin A in the Conservative Treatment of Fractures: An Experimental Study on Rats.

TheScientificWorldJournal | 2024 | Vampertzis T, Barmpagianni C, Bekiari C, Brellou GD

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflicts of interest. 20. Injury. 2003 Nov;34 Suppl 2:B31-42. doi: 10.1016/j.injury.2003.09.023. General principles for the clinical use of the LCP. Wagner M(1). Author information: (1)Klinik für Traumaand Sportmedizin, Wilhelminspital Wien, Austria. michael.wagner@unf.magwien.gv.at The...

PubMed Cohort / Comparative Study Evidence Moderate

[Scaphoid malunion].

Chirurgie de la main | 2008 | Saffar P

[Indexed for MEDLINE] 8. Bonekey Rep. 2014 Jul 30;3:550. doi: 10.1038/bonekey.2014.45. eCollection 2014. Quantitative phenotyping of bone fracture repair: a review. Casanova M(1), Schindeler A(2), Little D(2), Müller R(3), Schneider P(4). Author information: (1)Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich , Zurich, Switzerland ; Orthopaed...

PubMed Original Article Evidence Unclassified

Stability Analysis of Plate-Screw Fixation for Femoral Midshaft Fractures.

Materials (Basel, Switzerland) | 2023 | Basirom I, Daud R, Ijaz MF, Rojan MA

Conflict of interest statement: The authors declare no conflict of interest. 17. PLoS Comput Biol. 2018 Feb 2;14(2):e1005980. doi: 10.1371/journal.pcbi.1005980. eCollection 2018 Feb. Simulation enabled search for explanatory mechanisms of the fracture healing process. Kennedy RC(1), Marmor M(2), Marcucio R(2), Hunt CA(1). Author information: (1)Department of Bioengineering and...

Crossref Journal Article Evidence Unclassified

Three-Dimensional Computational Model Simulating the Initial Callus Growth during Fracture Healing in Long Bones: Application to Different Fracture Types

Bioengineering | 2023 | José M. Naveiro, Luis Gracia, Jorge Roces, Jorge Albareda

Bone fractures are among the most common and potentially serious injuries to the skeleton, femoral shaft fractures being especially severe. Thanks to recent advances in the area of in silico analysis, several approximations of the bone healing process have been achieved. In this context, the objective of this work was to simulate the initial phase of callus formation in long bo...

PubMed Narrative Review Evidence Moderate

Fracture healing: the diamond concept.

Injury | 2007 | Giannoudis PV, Einhorn TA, Marsh D

[Indexed for MEDLINE] 2. J Clin Invest. 2024 Jun 17;134(12):e181974. doi: 10.1172/JCI181974. Targeting senescent cells to boost bone fracture healing. Hofbauer LC(1)(2), Baschant U(1), Hofbauer C(3)(4). Author information: (1)Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III & University Center for Healthy Aging, Technische Universität Dresden Me...

PubMed Narrative Review Evidence Moderate

The enhancement of bone regeneration by ultrasound.

Progress in biophysics and molecular biology | 2007 | Claes L, Willie B

[Indexed for MEDLINE] 12. Front Endocrinol (Lausanne). 2021 May 24;12:667480. doi: 10.3389/fendo.2021.667480. eCollection 2021. Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. Chua K(1)(2)(3), Lee VK(4), Chan C(3), Yew A(2), Yeo E(4), Virshup DM(1)(5). Author information: (1)Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singa...

PubMed Original Article Evidence Unclassified

Callus formation in albino Wistar rats after femur fracture assessed by visible spectroscopy.

Biochemical and biophysical research communications | 2022 | Orban E, Pap Z, Micu AM, Sipos RS

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. 14. Vet Clin North Am Small Anim Pract. 1991 Jul;21(4):813-44. doi: 10.1016/s0195-5616(91)50085-1. Morphology of fracture nonunion and osteomyelitis. Woodard JC(1), Ris...

PubMed Original Article Evidence Unclassified

Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing.

Frontiers in endocrinology | 2021 | Chua K, Lee VK, Chan C, Yew A

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 13. Biochem Biophys Res Commun. 2022 Dec 17;634:168-174. doi: 10.1016/j.bbrc.2022.09.114. Epub 2022 Oct 7. Callus formation in albino Wistar rats after f...

PubMed Narrative Review Evidence Moderate

Application of histomorphometric methods to the study of bone repair.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 2005 | Gerstenfeld LC, Wronski TJ, Hollinger JO, Einhorn TA

[Indexed for MEDLINE] 7. Chir Main. 2008 Apr-Jun;27(2-3):65-75. doi: 10.1016/j.main.2008.05.004. Epub 2008 Jun 9. [Scaphoid malunion]. [Article in French] Saffar P(1). Author information: (1)Institut Français de Chirurgie de la Main, Paris, France. psaffar@ifcm.org Scaphoid fracture and healing are often difficult to diagnose. The scaphoid bone may heal in an abnormal position...

PubMed Original Article Evidence Unclassified

Simulation enabled search for explanatory mechanisms of the fracture healing process.

PLoS computational biology | 2018 | Kennedy RC, Marmor M, Marcucio R, Hunt CA

[Indexed for MEDLINE] Conflict of interest statement: The authors have declared that no competing interests exist. 18. J Biomech. 2000 Aug;33(8):961-8. doi: 10.1016/s0021-9290(00)00049-x. A fuzzy logic model of fracture healing. Ament C(1), Hofer EP. Author information: (1)Department of Measurement and Control, University of Bremen, Germany. A quantitative biomechanical model d...

Crossref Journal Article Evidence Unclassified

Early fracture callus displays smooth muscle‐like viscoelastic properties ex vivo: Implications for fracture healing

Journal of Orthopaedic Research | 2009 | Stuart J. McDonald, Philip C. Dooley, Aaron C. McDonald, Johannes A. Schuijers

AbstractCells of early, fibrous callus in bone fractures possess much alpha smooth muscle actin. This callus contracts and relaxes; however, active and passive components of its force production have yet to be defined. We aimed to establish whether passive viscoelastic properties of early soft fracture callus are smooth muscle‐like in nature. Under anesthesia one rib was fractu...

Crossref Journal Article Evidence Unclassified

Genes with greater up‐regulation in the fracture callus of older rats with delayed healing

Journal of Orthopaedic Research | 2007 | Martha H. Meyer, Ralph A. Meyer

AbstractThe rate of bone formation to bridge a fracture gap slows with age. To explore potential pathogenic mechanisms and possible negative‐feedback responses by the skeleton to this reduced rate of healing, mRNA transcripts up‐regulated more and/or longer were studied in older rats with delayed healing. Female rats at 6 (young), 26 (adult), and 52 (old) weeks of age received...

PubMed Narrative Review Evidence Moderate

Morphology of fracture nonunion and osteomyelitis.

The Veterinary clinics of North America. Small animal practice | 1991 | Woodard JC, Riser WH

[Indexed for MEDLINE] 15. Bone. 2024 Jun;183:117091. doi: 10.1016/j.bone.2024.117091. Epub 2024 Apr 2. Human nonunion tissues display differential gene expression in comparison to physiological fracture callus. Salichos L(1), Thayavally R(1), Kloen P(2), Hadjiargyrou M(3). Author information: (1)Department of Biological & Chemical Sciences, New York Institute of Technology, New...

PubMed Original Article Evidence Unclassified

A fuzzy logic model of fracture healing.

Journal of biomechanics | 2000 | Ament C, Hofer EP

[Indexed for MEDLINE] 19. ScientificWorldJournal. 2024 May 31;2024:7446251. doi: 10.1155/2024/7446251. eCollection 2024. The Role of Botulinum Neurotoxin A in the Conservative Treatment of Fractures: An Experimental Study on Rats. Vampertzis T(1), Barmpagianni C(2), Bekiari C(3), Brellou GD(4), Zervos IA(5), Tsiridis E(6), Galanis N(1). Author information: (1)Faculty of Medicin...

PubMed Original Article Evidence Unclassified

The footballer's fracture.

British journal of sports medicine | 1996 | Cattermole HR, Hardy JR, Gregg PJ

[Indexed for MEDLINE] 5. Orthopedics. 1984 Dec 1;7(12):1823-6. doi: 10.3928/0147-7447-19841201-08. Twenty years experience in fracture healing measurement with strain gauges. Burny F, Donkerwolcke M, Bourgois R, Domb M, Saric O. The external fixator provides a mechanical connection between the bone fragments and recording devices or power systems. We have used this characterist...

PubMed Original Article Evidence Unclassified

Twenty years experience in fracture healing measurement with strain gauges.

Orthopedics | 1984 | Burny F, Donkerwolcke M, Bourgois R, Domb M

6. J Bone Miner Res. 2005 Oct;20(10):1715-22. doi: 10.1359/JBMR.050702. Epub 2005 Jul 5. Application of histomorphometric methods to the study of bone repair. Gerstenfeld LC(1), Wronski TJ, Hollinger JO, Einhorn TA. Author information: (1)Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA. Stand...