Evidence Search

CASC20 IS A SUSCEPTIBILITY GENE FOR HETEROTOPIC OSSIFICATION AFTER HIP ARTHROPLASTY

Orthopaedic Proceedings | 2026 | J Mark Wilkinson

Purpose The term heterotopic ossification (HO) describes bone formation that occurs within tissues that do not normally ossify, resulting in pain and disability. However, why some patients suffer HO and others do not is unstudied. Methods Here, we use genome-wide association analysis in a population of ~1,000 patients after hip replacement (~40% with some degree of HO formation...

Heterotopic hip ossification resection: monocentric experiences of associated factors, outcomes, and complications.

International orthopaedics | 2024 | Zampogna B, Laudisio A, Papalia GF, Vorini F

[Indexed for MEDLINE] 7. Eur J Orthop Surg Traumatol. 2023 May;33(4):1037-1041. doi: 10.1007/s00590-022-03244-9. Epub 2022 Mar 19. Heterotopic ossification in primary total hip arthroplasty: risk factor analysis. Aprato A(1), Cambursano S(2), Artiaco S(2), Bevilacqua S(2), Catalani P(2), Massè A(2). Author information: (1)University of Turin, Viale 25 aprile 137 int 6, 10133, T...

Heterotopic ossification in primary total hip arthroplasty: risk factor analysis.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2023 | Aprato A, Cambursano S, Artiaco S, Bevilacqua S

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that there is no conflict of interest. 8. Bone Joint J. 2017 Oct;99-B(10):1399-1408. doi: 10.1302/0301-620X.99B10.BJJ-2016-1261.R2. Cemented total hip arthroplasty following acetabular fracture. Scott CEH(1), MacDonald D(1), Moran M(1), White TO(1), Patton JT(1), Keating JF(1). Author information: (1)Roya...

Outcomes of Total Hip Replacement for Failed Hemiarthroplasty.

Indian journal of orthopaedics | 2023 | Rajkumar N, Soundarrajan D, Ram G, Dhanasekararaja P

Conflict of interest statement: Conflict of interestNatesan Rajkumar, Dhanasekaran Soundarrajan, Gowtham Ram, Palanisami Dhanasekararaja and Shanmuganathan Rajasekaran declare that they have no conflict of interest. 20. Orthopedics. 2017 Jan 1;40(1):e54-e58. doi: 10.3928/01477447-20160926-05. Epub 2016 Sep 30. Intraobserver Reliability and Interobserver Agreement in Radiographi...

Heterotopic ossification after total hip arthroplasty: When is development completed?

Journal of orthopaedic surgery and research | 2022 | Willburger RE, Brinkhoff F, Nottenkämper J, Krapp J

[Indexed for MEDLINE] Conflict of interest statement: All authors declare that they have no competing interests. 6. Int Orthop. 2024 Mar;48(3):699-704. doi: 10.1007/s00264-023-05993-6. Epub 2023 Sep 30. Heterotopic hip ossification resection: monocentric experiences of associated factors, outcomes, and complications. Zampogna B(1)(2), Laudisio A(3)(4)(5), Papalia GF(1)(2), Vori...

Does drainage affect development of heterotopic ossification after total hip arthroplasty?

The Journal of international medical research | 2022 | Wei C, Yang M, Chu K, Huo J

[Indexed for MEDLINE] 16. J Arthroplasty. 2014 Feb;29(2):390-2. doi: 10.1016/j.arth.2013.06.039. Epub 2013 Aug 6. Celecoxib and heterotopic bone formation after total hip arthroplasty. Lavernia CJ(1), Contreras JS(2), Villa JM(2), Rossi MD(3). Author information: (1)Orthopaedic Institute at Mercy Hospital, Miami, Florida. (2)Arthritis Surgery Research Foundation, Miami, Florida...

Heterotopic ossification after total hip arthroplasty: radiological comparison between a direct anterior approach without an orthopaedic table and a posterior approach

HIP International | 2022 | Naïm Zran, Etienne Joseph, Gabriel Callamand, Xavier Ohl

Introduction: Heterotopic ossification (HO) occurs in almost ⅓ of total hip arthroplasties (THAs). A direct anterior approach (DAA) with an orthopaedic table is less likely to cause HO than a posterior approach. Without an orthopaedic table, the exposure of the femur requires additional soft tissue release. Soft tissue trauma leads to the production of HO inductors. Our study e...

Heterotopic Ossification Following Arthroplasty for Femoral Neck Fracture.

The Journal of bone and joint surgery. American volume | 2021 | Comeau-Gauthier M, Zura RD, Bzovsky S, Schemitsch EH

[Indexed for MEDLINE] Conflict of interest statement: Disclosure: The Hip Fracture Evaluation with Alternatives of Total Hip Arthroplasty versus Hemiarthroplasty (HEALTH) trial was supported by research grants from the Canadian Institutes of Health Research (CIHR) (MCT-90168), National Institutes of Health (NIH) (1UM1AR063386-01), ZorgOnderzoek Nederland-medische wetensehappen...

Staged Total Hip Arthroplasty: A Novel Technique in Managing Native and Periprosthetic Acetabular Insufficiency.

Arthroplasty today | 2021 | Horberg JV, Bailey JR, Kay K, Allan DG

19. Indian J Orthop. 2023 Mar 2;57(5):679-688. doi: 10.1007/s43465-023-00849-y. eCollection 2023 May. Outcomes of Total Hip Replacement for Failed Hemiarthroplasty. Rajkumar N(1), Soundarrajan D(1), Ram G(1), Dhanasekararaja P(1), Rajasekaran S(1). Author information: (1)Department of Orthopaedics, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641043 India. AIM: Our study...

Surgical treatment of femoral head fractures.

Biomedical journal | 2020 | Peng SH, Wu CC, Yu YH, Lee PC

[Indexed for MEDLINE] 5. J Orthop Surg Res. 2022 Mar 5;17(1):147. doi: 10.1186/s13018-022-02959-z. Heterotopic ossification after total hip arthroplasty: When is development completed? Willburger RE(1), Brinkhoff F(1), Nottenkämper J(1), Krapp J(1), Oberberg S(2). Author information: (1)Department of Orthopaedic Surgery, Martin-Luther-Krankenhaus, Voedestrasse 79, 44866, Bochum...

Total hip arthroplasty following acetabular fracture: a clinical and radiographic outcome analysis of 67 patients.

Archives of orthopaedic and trauma surgery | 2020 | Busch A, Stöckle U, Schreiner A, de Zwaart P

[Indexed for MEDLINE] 15. J Int Med Res. 2022 Oct;50(10):3000605221129562. doi: 10.1177/03000605221129562. Does drainage affect development of heterotopic ossification after total hip arthroplasty? Wei C(1), Yang M(2), Chu K(2), Huo J(2), Chen X(2), Li H(2). Author information: (1)Department of Joint Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, P.R....

Histopathology of periarticular non-hereditary heterotopic ossification.

Bone | 2018 | Foley KL, Hebela N, Keenan MA, Pignolo RJ

[Indexed for MEDLINE] 13. Bone Joint J. 2016 Jun;98-B(6):761-6. doi: 10.1302/0301-620X.98B6.36050. Ethnic differences in heterotopic ossification following total hip arthroplasty. Davis G(1), Patel RP(1), Tan TL(1), Alijanipour P(1), Naik TU(1), Parvizi J(1). Author information: (1)Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA. AIMS: We aimed to assess t...

Heterotopic ossification.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2002 | Shehab D, Elgazzar AH, Collier BD

[Indexed for MEDLINE] 2. Orthop Clin North Am. 2023 Jan;54(1):37-46. doi: 10.1016/j.ocl.2022.08.007. Heterotopic Ossification after Trauma. Lawand J(1), Loeffelholz Z(2), Khurshid B(3), Barcak E(2). Author information: (1)Department of Orthopaedic Surgery, John Peter Smith Health Network, Fort Worth, Texas, USA. Electronic address: jadjlawand@gmail.com. (2)Department of Orthopa...

Cemented total hip arthroplasty following acetabular fracture.

The bone & joint journal | 2017 | Scott CEH, MacDonald D, Moran M, White TO

[Indexed for MEDLINE] 9. Bone Joint J. 2016 Sep;98-B(9):1215-21. doi: 10.1302/0301-620X.98B9.37761. Heterotopic ossification after reverse total shoulder arthroplasty. Verhofste B(1), Decock T(1), Van Tongel A(1), De Wilde L(1). Author information: (1)Ghent University Hospital, 185 De Pintelaan, 9000 Ghent, Belgium. AIMS: Heterotopic ossification (HO) occurs after arthroplasty,...

Total hip arthroplasty for acetabular fractures: "Early Application".

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES | 2017 | Salar N, Bilgen MS, Bilgen ÖF, Ermutlu C

[Indexed for MEDLINE] 12. Bone. 2018 Apr;109:65-70. doi: 10.1016/j.bone.2017.12.006. Epub 2017 Dec 7. Histopathology of periarticular non-hereditary heterotopic ossification. Foley KL(1), Hebela N(2), Keenan MA(3), Pignolo RJ(4). Author information: (1)Boston Osteopathic Health and University of Massachusetts Medical School, Worcester and Newton, MA, United States. Electronic a...

Intraobserver Reliability and Interobserver Agreement in Radiographic Classification of Heterotopic Ossification.

Orthopedics | 2017 | Vasileiadis GI, Itoigawa Y, Amanatullah DF, Pulido-Sierra L

[Indexed for MEDLINE]

Heterotopic Ossification

Complications after Primary Total Hip Arthroplasty | 2017 | Michael J. Taunton

Heterotopic ossification after reverse total shoulder arthroplasty.

The bone & joint journal | 2016 | Verhofste B, Decock T, Van Tongel A, De Wilde L

[Indexed for MEDLINE] 10. J Clin Orthop Trauma. 2015 Mar;6(1):1-5. doi: 10.1016/j.jcot.2014.11.004. Epub 2014 Dec 26. Heterotopic ossification after hemiarthroplasty of the hip - A comparison of three common approaches. Corrigan CM(1), Greenberg SE(1), Sathiyakumar V(1), Mitchell PM(1), Francis A(1), Omar A(1), Thakore RV(1), Obremskey WT(1), Sethi MK(1). Author information: (1...

Ethnic differences in heterotopic ossification following total hip arthroplasty.

The bone & joint journal | 2016 | Davis G, Patel RP, Tan TL, Alijanipour P

[Indexed for MEDLINE] 14. Arch Orthop Trauma Surg. 2020 Mar;140(3):331-341. doi: 10.1007/s00402-019-03272-x. Epub 2019 Sep 9. Total hip arthroplasty following acetabular fracture: a clinical and radiographic outcome analysis of 67 patients. Busch A(1)(2), Stöckle U(3), Schreiner A(3), de Zwaart P(3), Schäffler A(3)(4), Ochs BG(3). Author information: (1)Department of Orthopaedi...

Total hip arthroplasty in patients with ankylosing spondylitis: Midterm radiologic and functional results.

Acta orthopaedica et traumatologica turcica | 2016 | Saglam Y, Ozturk I, Cakmak MF, Ozdemir M

[Indexed for MEDLINE] 18. Arthroplast Today. 2021 May 31;9:78-82. doi: 10.1016/j.artd.2021.04.014. eCollection 2021 Jun. Staged Total Hip Arthroplasty: A Novel Technique in Managing Native and Periprosthetic Acetabular Insufficiency. Horberg JV(1)(2), Bailey JR(1), Kay K(1), Allan DG(1)(2). Author information: (1)Division of Orthopaedic Surgery, Southern Illinois University Sch...

Heterotopic ossification after hemiarthroplasty of the hip - A comparison of three common approaches.

Journal of clinical orthopaedics and trauma | 2015 | Corrigan CM, Greenberg SE, Sathiyakumar V, Mitchell PM

11. Ulus Travma Acil Cerrahi Derg. 2017 Jul;23(4):337-342. doi: 10.5505/tjtes.2016.55675. Total hip arthroplasty for acetabular fractures: "Early Application". Salar N, Bilgen MS(1), Bilgen ÖF, Ermutlu C, Eken G, Durak K. Author information: (1)Department of Orthopedics and Traumatology, Uludağ University Faculty of Medicine, Bursa-Turkey. msbilgen@superonline.com. BACKGROUND:...

Celecoxib and heterotopic bone formation after total hip arthroplasty.

The Journal of arthroplasty | 2014 | Lavernia CJ, Contreras JS, Villa JM, Rossi MD

[Indexed for MEDLINE] 17. Acta Orthop Traumatol Turc. 2016 Aug;50(4):443-7. doi: 10.1016/j.aott.2016.06.010. Epub 2016 Aug 1. Total hip arthroplasty in patients with ankylosing spondylitis: Midterm radiologic and functional results. Saglam Y(1), Ozturk I(2), Cakmak MF(2), Ozdemir M(2), Yazicioglu O(2). Author information: (1)Biruni University Hospital, Orthopedics and Traumatol...

Incidence of Heterotopic Ossification in Patients Receiving Radiation Therapy following Total Hip Arthroplasty

Advances in Orthopedic Surgery | 2014 | Panagiotis Koulouvaris, David Sherr, Thomas Sculco

Heterotopic ossification (HO) is a frequent complication of hip surgery. In this study the incidence of HO is analyzed in high risk patients who received radiation therapy (RT) after total hip replacement (THA) with regular and miniposterolateral hip approach. Two hundred and thirty five high risk patients received a single dose of 700 rad after THA. The incidence of HO was 15....

Avoiding and Treating Heterotopic Ossification After Total Hip Arthroplasty

Seminars in Arthroplasty | 2012 | Torrance A. Walker, William M. Mihalko

Heterotopic ossification of the hip after stroke

Current Orthopaedic Practice | 2011 | Rebecca Ann Halas, Saravanavail Karuppiah

Severe heterotopic ossification after total hip arthroplasty in Schnitzler syndrome

HIP International | 2010 | Emilio Romanini, Massimiliano Magaletti, Lucrezia D'Aviera, Stefano Antonelli

Schnitzler syndrome is a rare disorder characterized by monoclonal IgM gammopathy, urticaria, recurrent fever, evidence of inflammation, bone pain, and arthralgia. We present the case of a patient affected by Schnitzler syndrome who developed Della Valle type C heterotopic ossification after total hip arthroplasty. A relationship between the underlying syndrome and the consider...

Complications after Total Hip Arthroplasty: Heterotopic Ossification

Seminars in Arthroplasty | 2005 | Stephen R. Kantor, Justin Cummins, Michael Tanzer

Trochanteric Heterotopic Ossification After Total Hip Arthroplasty Performed Using a Direct Lateral Approach

The Journal of Arthroplasty | 2005 | Steven F. Harwin

Biochemical markers of bone turnover and development of heterotopic ossification after total hip arthroplasty

Journal of Orthopaedic Research | 2003 | J. Mark Wilkinson, Ian Stockley, Andrew J. Hamer, N. Ann Barrington

AbstractWe studied biochemical markers of bone turnover markers in 20 men and women over 26 weeks after total hip arthroplasty (THA) in order to characterize the changes in bone metabolism associated with developing heterotopic ossification (HO). Transient increases in biochemical markers of both osteoclast and osteoblast activity occurred after surgery. Subjects developing HO...

Heterotopic Ossification After Hip and Knee Arthroplasty: Risk Factors, Prevention, and Treatment

Journal of the American Academy of Orthopaedic Surgeons | 2002 | Richard Iorio, William L. Healy

Risk factors for heterotopic ossification in total hip arthroplasty

Archives of Orthopaedic and Trauma Surgery | 2001 | S. Eggli, A. Woo

Heterotopic ossification after uncemented hydroxyapatite-coated primary total hip arthroplasty

The Journal of Arthroplasty | 2001 | Ravikumar J. Kasetti, A.A. Shetty, C. Rand

Heterotopic Ossification

Revision Total Hip Arthroplasty | 1999 | Douglas E. Padgett