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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Osteosarcoma — Diagnosis & Treatment
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
Crossref PubMed
Crossref Review Article Evidence Moderate

Primary Cardiac Osteosarcoma: Epidemiology, Diagnosis, and Management — A Narrative Review

Orthopedic Reviews | 2025 | Tommy Li, Eric Nguyen, Jamal Hasoon, Ali Khalifa

Purpose Primary cardiac sarcomas are exceedingly rare, with a very low incidence in the general population. A variety of sarcoma subtypes can originate in the heart, including angiosarcoma, rhabdomyosarcoma, leiomyosarcoma, fibrosarcoma, and osteosarcoma. These tumors are typically classified based on histological characteristics, most often determined following surgical excisi...

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PubMed Narrative Review Evidence Moderate

Management of osteosarcoma of the head and neck.

Current opinion in otolaryngology & head and neck surgery | 2023 | Sharin F, Pai A, Mair M

[Indexed for MEDLINE] 7. Eur Arch Otorhinolaryngol. 2014 Oct;271(10):2601-9. doi: 10.1007/s00405-013-2807-3. Epub 2013 Nov 10. Chondrosarcomas of the head and neck. Coca-Pelaz A(1), Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A. Author information: (1)Department of Otolaryngology, Hospital Universitario Central...

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PubMed Narrative Review Evidence Moderate

Return to Sports and Activity in Tumor Orthopaedics.

Zeitschrift fur Orthopadie und Unfallchirurgie | 2023 | Mester B, Guder W, Streitbürger A, Schoepp C

[Indexed for MEDLINE] Conflict of interest statement: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht. 20. Prog Tumor Res. 2016;43:128-41. doi: 10.1159/000447083. Epub 2016 Sep 5. Sarcomas of Soft Tissue and Bone. Ferrari A, Dirksen U, Bielack S. The definition of soft tissue and bone sarcomas include a large group of several heterogeneous subtypes of mese...

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PubMed Narrative Review Evidence Moderate

Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs.

Cancer letters | 2021 | Chen C, Xie L, Ren T, Huang Y

[Indexed for MEDLINE] 2. Pharmacogenomics J. 2017 Jan;17(1):11-20. doi: 10.1038/tpj.2016.45. Epub 2016 May 31. The pharmacogenomics of osteosarcoma. Serra M(1), Hattinger CM(1). Author information: (1)Laboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy. Osteosarcoma (OS), the most common malignant tumor of bone, is presently treated with multidrug...

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PubMed Narrative Review Evidence Moderate

Immunotherapy for sarcomas: new frontiers and unveiled opportunities.

Journal for immunotherapy of cancer | 2021 | Birdi HK, Jirovec A, Cortés-Kaplan S, Werier J

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: J-SD is an inventor on patents licensed to Turnstone Biologics, which is commercializing oncolytic Maraba virus. J-SD has patents licensed and also holds equity in Virica Biotech, which is developing oncolytic virus platforms. 4. Orthopadie (Heidelb). 2023 Jun;52(6):509-522. doi: 10.1007/s00132-023-04387...

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PubMed Narrative Review Evidence Moderate

Osteosarcoma: a review of current and future therapeutic approaches.

Biomedical engineering online | 2021 | Zhao X, Wu Q, Gong X, Liu J

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests. 16. Biosensors (Basel). 2021 Feb 20;11(2):55. doi: 10.3390/bios11020055. Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma. Barani M(1), Mukhtar M(2), Rahdar A(3), Sargazi S(4), Pandey S(5)(6), Kang M(6). Author information: (1)Department of Che...

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PubMed Narrative Review Evidence Moderate

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.

Biosensors | 2021 | Barani M, Mukhtar M, Rahdar A, Sargazi S

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. 17. Rev Med Inst Mex Seguro Soc. 2024 Mar 4;62(2):1-6. doi: 10.5281/zenodo.10712277. [Superficial extraskeletal osteosarcoma. Case report]. [Article in Spanish; Abstract available in Spanish from the publisher] García-Esparza PE(1), Mantilla Morales A(2). Author information: (1)In...

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PubMed Narrative Review Evidence Moderate

Therapeutic Targets for Bone and Soft-Tissue Sarcomas.

International journal of molecular sciences | 2019 | Miwa S, Yamamoto N, Hayashi K, Takeuchi A

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. 15. Biomed Eng Online. 2021 Mar 2;20(1):24. doi: 10.1186/s12938-021-00860-0. Osteosarcoma: a review of current and future therapeutic approaches. Zhao X(#)(1), Wu Q(#)(2), Gong X(3), Liu J(2), Ma Y(2). Author information: (1)Anhui Chest Hospital, 397 Jixi Road, Hefei, 230022, Chin...

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PubMed Narrative Review Evidence Moderate

Understanding osteosarcomas.

JAAPA : official journal of the American Academy of Physician Assistants | 2018 | Simpson E, Brown HL

[Indexed for MEDLINE] 9. Clin Exp Metastasis. 2020 Apr;37(2):269-281. doi: 10.1007/s10585-019-10012-3. Epub 2019 Dec 20. Skeletal impact of 17β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation. Cheng JN(1), Frye JB(2), Whitman SA(2), Funk JL(3)(4). Author information: (1)Cancer Biology Graduate Interdisciplinary Program, University of Ar...

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PubMed Narrative Review Evidence Moderate

The pharmacogenomics of osteosarcoma.

The pharmacogenomics journal | 2017 | Serra M, Hattinger CM

[Indexed for MEDLINE] 3. J Immunother Cancer. 2021 Feb;9(2):e001580. doi: 10.1136/jitc-2020-001580. Immunotherapy for sarcomas: new frontiers and unveiled opportunities. Birdi HK(#)(1)(2)(3), Jirovec A(#)(1)(2)(3), Cortés-Kaplan S(#)(1)(2)(3), Werier J(4)(5), Nessim C(1)(5), Diallo JS(#)(1)(2)(3), Ardolino M(#)(6)(2)(3). Author information: (1)Cancer Therapeutics Program, Ottaw...

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PubMed Narrative Review Evidence Moderate

Multidisciplinary approach to osteosarcoma.

Acta orthopaedica Belgica | 2016 | Biazzo A, De Paolis M

[Indexed for MEDLINE] 6. Curr Opin Otolaryngol Head Neck Surg. 2023 Aug 1;31(4):269-275. doi: 10.1097/MOO.0000000000000900. Epub 2023 May 3. Management of osteosarcoma of the head and neck. Sharin F(1), Pai A(2), Mair M(1). Author information: (1)University hospital of Leicester, Leicester, UK. (2)HCG Hospital, Mumbai, India. PURPOSE OF REVIEW: There is no clear consensus guide...

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PubMed Narrative Review Evidence Moderate

Chondrosarcomas of the head and neck.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2014 | Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL

[Indexed for MEDLINE] 8. JAAPA. 2018 Aug;31(8):15-19. doi: 10.1097/01.JAA.0000541477.24116.8d. Understanding osteosarcomas. Simpson E(1), Brown HL. Author information: (1)At the time this article was written, Emily Simpson was a student in the PA program at Mercer University in Atlanta, Ga. She now practices urgent care medicine with Georgia Emergency Associates in Savannah, Ga...

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PubMed Narrative Review Evidence Moderate

Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-EDTMP and radium-223.

Advances in experimental medicine and biology | 2014 | Anderson PM, Subbiah V, Rohren E

[Indexed for MEDLINE] 14. Int J Mol Sci. 2019 Jan 4;20(1):170. doi: 10.3390/ijms20010170. Therapeutic Targets for Bone and Soft-Tissue Sarcomas. Miwa S(1), Yamamoto N(2), Hayashi K(3), Takeuchi A(4), Igarashi K(5), Tsuchiya H(6). Author information: (1)Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa 920-8640, Japan. smiwa001@yahoo.co.jp. (2)D...

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PubMed Case Report / Series Evidence Low

[Superficial extraskeletal osteosarcoma. Case report].

Revista medica del Instituto Mexicano del Seguro Social | 2024 | García-Esparza PE, Mantilla Morales A

[Indexed for MEDLINE] Conflict of interest statement: los autores han completado y enviado la forma traducida al español de la declaración de conflictos potenciales de interés del Comité Internacional de Editores de Revistas Médicas, y no fue reportado alguno que tuviera relación con este artículo. 18. Curr Opin Oncol. 2000 Jul;12(4):330-6. doi: 10.1097/00001622-200007000-00009...

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PubMed Narrative Review Evidence Moderate

Bone tumors: osteosarcoma and Ewing's sarcoma.

Current opinion in pediatrics | 2009 | Heare T, Hensley MA, Dell'Orfano S

[Indexed for MEDLINE] 11. Curr Treat Options Oncol. 2009 Apr;10(1-2):82-93. doi: 10.1007/s11864-009-0087-3. Epub 2009 Feb 24. The multidisciplinary management of osteosarcoma. Federman N(1), Bernthal N, Eilber FC, Tap WD. Author information: (1)Division of Pediatric Hematology/Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA....

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PubMed Narrative Review Evidence Moderate

The multidisciplinary management of osteosarcoma.

Current treatment options in oncology | 2009 | Federman N, Bernthal N, Eilber FC, Tap WD

[Indexed for MEDLINE] 12. J Am Acad Orthop Surg. 2009 Aug;17(8):515-27. doi: 10.5435/00124635-200908000-00005. Osteosarcoma. Messerschmitt PJ(1), Garcia RM, Abdul-Karim FW, Greenfield EM, Getty PJ. Author information: (1)Department of Orthopaedic Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA. Osteosarcoma, the most...

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PubMed Narrative Review Evidence Moderate

Osteosarcoma.

The Journal of the American Academy of Orthopaedic Surgeons | 2009 | Messerschmitt PJ, Garcia RM, Abdul-Karim FW, Greenfield EM

[Indexed for MEDLINE] 13. Adv Exp Med Biol. 2014;804:291-304. doi: 10.1007/978-3-319-04843-7_16. Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-EDTMP and radium-223. Anderson PM(1), Subbiah V, Rohren E. Author information: (1)Levine Children's Hospital, Charlotte, NC, USA, peter.anderson@carolinashealthcare.org. Osteosarcoma is a cancer chara...

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PubMed Original Article Evidence Unclassified

[Primary malignant bone tumors].

Orthopadie (Heidelberg, Germany) | 2023 | Funovics PT

[Indexed for MEDLINE] 5. Acta Orthop Belg. 2016 Dec;82(4):690-698. Multidisciplinary approach to osteosarcoma. Biazzo A, De Paolis M. Osteosarcoma is a malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Osteosarcoma is the most frequent primary malignant bone tumor, if we excluded myeloma, a haematologic disease. The incidence of osteosarcom...

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PubMed Original Article Evidence Unclassified

Skeletal impact of 17β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation.

Clinical & experimental metastasis | 2020 | Cheng JN, Frye JB, Whitman SA, Funk JL

[Indexed for MEDLINE] 10. Curr Opin Pediatr. 2009 Jun;21(3):365-72. doi: 10.1097/MOP.0b013e32832b1111. Bone tumors: osteosarcoma and Ewing's sarcoma. Heare T(1), Hensley MA, Dell'Orfano S. Author information: (1)Musculoskeletal Tumor Program, Department of Orthopaedic Surgery, University of Colorado, The Children's Hospital, Denver, CO, USA. heare.travis@tchden.org PURPOSE OF R...

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PubMed Narrative Review Evidence Moderate

Osteosarcomas and other cancers of bone.

Current opinion in oncology | 2000 | Bramwell VH

[Indexed for MEDLINE] 19. Z Orthop Unfall. 2023 Aug;161(4):385-395. doi: 10.1055/a-1676-5266. Epub 2021 Dec 8. Return to Sports and Activity in Tumor Orthopaedics. [Article in English, German; Abstract available in German from the publisher] Mester B(1), Guder W(2), Streitbürger A(2), Schoepp C(3), Nottrott M(2), Podleska L(2), Dudda M(4)(1), Hardes J(2). Author information: (1...

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