Orthopedic Mechanophenotype: A Structured Narrative Review of Multiscale Biomechanics, Mechanotransduction, and Clinical Decision‐Making
Orthopaedic Surgery | 2026 | Zihao Lan, Zhipeng Mu, Hongjian Li
ABSTRACT Orthopedic disorders are still classified mainly by anatomy or end‐stage morphology, yet osteoporosis, osteoarthritis, fracture nonunion, spinal degeneration, and bone‐implant interface failure share a common mechanobiological logic: external load is filtered by hierarchical tissue architecture, converted into cell‐scale signals, and integrated with inflammation, metab...