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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Haemophilic Arthropathy
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Systematic Review / Meta-analysis Evidence High

Surgery for chronic arthropathy in people with haemophilia.

The Cochrane database of systematic reviews | 2022 | Chin B, Wee I, Syn NL, O'Neill GK

[Indexed for MEDLINE] Conflict of interest statement: Brian Chin: none known Ian Wee: none known Nicholas Syn: none known Gavin O'Neill: none known Eng Soo Yap: none known Pei Lin Koh: none known 15. Blood. 2026 Jan 15;147(3):299-311. doi: 10.1182/blood.2024027143. Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy. Kavadipula P(1),...

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PubMed Narrative Review Evidence Moderate

Unmet needs in hemophilic arthropathy.

Blood reviews | 2025 | Dargaud Y, Lobet S, Roussel N, Valentino LA

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflicts of interest related to this article. 3. Orthopedics. 2017 Nov 1;40(6):e940-e946. doi: 10.3928/01477447-20170619-05. Epub 2017 Jun 30. Hemophilic Arthropathy. Nacca CR, Harris AP, Tuttle JR. The musculoskeletal manifestations of hemophilia A and B are some of...

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PubMed Narrative Review Evidence Moderate

Soft Tissue Pathology.

Clinics in podiatric medicine and surgery | 2023 | Shane AM, Reeves CL, Nguyen GB, Ferrise TD

[Indexed for MEDLINE] 14. Cochrane Database Syst Rev. 2022 Nov 30;11(11):CD013634. doi: 10.1002/14651858.CD013634.pub2. Surgery for chronic arthropathy in people with haemophilia. Chin B(1), Wee I(2), Syn NL(2), O'Neill GK(1), Yap ES(3), Koh PL(4). Author information: (1)Department of Orthopaedic Surgery, National University Health System, Singapore, Singapore. (2)Department of...

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PubMed Narrative Review Evidence Moderate

Hemophilic arthropathy: Current knowledge and future perspectives.

Journal of thrombosis and haemostasis : JTH | 2021 | Gualtierotti R, Solimeno LP, Peyvandi F

[Indexed for MEDLINE] Conflict of interest statement: Dr. Gualtierotti is a member of advisory boards of Biomarin, Pfizer, Bayer, and Takeda, and participates in educational seminars sponsored by Pfizer, Sobi, and Roche. Dr. Peyvandi is a member of advisory boards of Bioverativ, Grifols, Roche, Sanofi, Sobi, Spark, and Takeda. Dr. Solimeno has no disclosure to make. 2. Blood Re...

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PubMed Narrative Review Evidence Moderate

Pathological mechanism of joint destruction in haemophilic arthropathy.

Molecular biology reports | 2021 | Zhu H, Meng Y, Tong P, Zhang S

[Indexed for MEDLINE] 5. J Am Acad Orthop Surg. 2004 Jul-Aug;12(4):234-45. doi: 10.5435/00124635-200407000-00004. Hemophilic arthropathy. Luck JV Jr(1), Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS. Author information: (1)Orthopaedics-Hemophilia Treatment Center, Orthopaedic Hospital, Los Angeles, CA 90007, USA. The most common clinical manifestation of hemoph...

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PubMed Narrative Review Evidence Moderate

Joint disease in haemophilia: Pathophysiology, pain and imaging.

Haemophilia : the official journal of the World Federation of Hemophilia | 2018 | van Vulpen LFD, Holstein K, Martinoli C

[Indexed for MEDLINE] 9. Semin Hematol. 2016 Jan;53(1):10-9. doi: 10.1053/j.seminhematol.2015.10.005. Epub 2015 Oct 26. Advances and challenges in hemophilic arthropathy. Wyseure T(1), Mosnier LO(1), von Drygalski A(2). Author information: (1)The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA, USA. (2)The Scripps Research Institute,...

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PubMed Narrative Review Evidence Moderate

Cytokines in the pathogenesis of hemophilic arthropathy.

Cytokine & growth factor reviews | 2018 | Wojdasiewicz P, Poniatowski ŁA, Nauman P, Mandat T

[Indexed for MEDLINE] 13. Clin Podiatr Med Surg. 2023 Jul;40(3):381-395. doi: 10.1016/j.cpm.2023.02.003. Epub 2023 Apr 28. Soft Tissue Pathology. Shane AM(1), Reeves CL(2), Nguyen GB(3), Ferrise TD(3), Calaj PM(3). Author information: (1)Department of Podiatric Surgery Advent Health System, Advent Health East Orlando Podiatric Surgery Residency, Upperline Health, 250 North Alaf...

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PubMed Narrative Review Evidence Moderate

Hemophilic Arthropathy.

Orthopedics | 2017 | Nacca CR, Harris AP, Tuttle JR

[Indexed for MEDLINE] 4. Mol Biol Rep. 2021 Jan;48(1):969-974. doi: 10.1007/s11033-020-06052-8. Epub 2020 Dec 8. Pathological mechanism of joint destruction in haemophilic arthropathy. Zhu H(1), Meng Y(1), Tong P(2), Zhang S(3). Author information: (1)The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China. (2)Department o...

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PubMed Narrative Review Evidence Moderate

Pathophysiology of hemophilic arthropathy and potential targets for therapy.

Pharmacological research | 2017 | Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP

[Indexed for MEDLINE] 17. Thromb Haemost. 2013 Jun;109(6):1170-9. doi: 10.1160/TH12-11-0874. Epub 2013 Apr 4. Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US). Martinoli C(1), Della Casa Alberighi O, Di Minno G, Graziano E, Molinari AC, Pasta G, Russo G, Santagostino E, Tagliaf...

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PubMed Narrative Review Evidence Moderate

Advances and challenges in hemophilic arthropathy.

Seminars in hematology | 2016 | Wyseure T, Mosnier LO, von Drygalski A

[Indexed for MEDLINE] 10. Haemophilia. 2008 Jul;14 Suppl 4:11-9. doi: 10.1111/j.1365-2516.2008.01734.x. Management of haemophilic arthropathy. Bossard D(1), Carrillon Y, Stieltjes N, Larbre JP, Laurian Y, Molina V, Dirat G. Author information: (1)Department of Radiology, Centre Orthopedic Santy, Lyon, France. Despite the tremendous benefit offered by primary prophylaxis, recurr...

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PubMed Narrative Review Evidence Moderate

Assessment of Hemophilic Arthropathy by Ultrasound: Where Do We Stand?

Seminars in thrombosis and hemostasis | 2016 | Di Minno MN, Ambrosino P, Quintavalle G, Coppola A

[Indexed for MEDLINE] 19. Clin Radiol. 2009 Nov;64(11):1119-28. doi: 10.1016/j.crad.2009.07.005. Epub 2009 Sep 17. Imaging and staging of haemophilic arthropathy. Jelbert A(1), Vaidya S, Fotiadis N. Author information: (1)Radiology Department, Barts and The London NHS trust, London, UK. Arthropathy is one of the most disabling consequences of haemophilia. The management of this...

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PubMed Original Article Evidence Unclassified

Factor VIIa-released extracellular vesicles attenuate joint bleed-induced hemophilic arthropathy.

Blood | 2026 | Kavadipula P, Keshava S, Das K, Magisetty J

[Indexed for MEDLINE] Conflict of interest statement: Conflict-of-interest disclosure: The authors declare no competing financial interests. Usha R. Pendurthi died on 1 May 2022. 16. Pharmacol Res. 2017 Jan;115:192-199. doi: 10.1016/j.phrs.2016.11.032. Epub 2016 Nov 24. Pathophysiology of hemophilic arthropathy and potential targets for therapy. Pulles AE(1), Mastbergen SC(2),...

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PubMed Original Article Evidence Unclassified

Haemophilic arthropathy: Diagnosis, management, and aging patient considerations.

Haemophilia : the official journal of the World Federation of Hemophilia | 2024 | Bakeer N, Saied W, Gavrilovski A, Bailey C

[Indexed for MEDLINE] 8. Haemophilia. 2018 May;24 Suppl 6:44-49. doi: 10.1111/hae.13449. Joint disease in haemophilia: Pathophysiology, pain and imaging. van Vulpen LFD(1), Holstein K(2), Martinoli C(3). Author information: (1)Van Creveldkliniek University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. (2)University Medical Centre Hamburg-Eppendorf, Hambu...

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PubMed Narrative Review Evidence Moderate

Imaging and staging of haemophilic arthropathy.

Clinical radiology | 2009 | Jelbert A, Vaidya S, Fotiadis N

[Indexed for MEDLINE] 20. Haemophilia. 2006 Jul;12 Suppl 3:108-12. doi: 10.1111/j.1365-2516.2006.01266.x. Physiotherapy following elective orthopaedic procedures. De Kleijn P(1), Blamey G, Zourikian N, Dalzell R, Lobet S. Author information: (1)UMC Utrecht, Utrecht, The Netherlands. p.dekleijn@umtrecht.nl As haemophilic arthropathy and chronic synovitis are still the most impor...

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PubMed Narrative Review Evidence Moderate

Physiopathology of haemophilic arthropathy.

Haemophilia : the official journal of the World Federation of Hemophilia | 2008 | Lafeber FP, Miossec P, Valentino LA

[Indexed for MEDLINE] 7. Haemophilia. 2024 Apr;30 Suppl 3:120-127. doi: 10.1111/hae.15004. Epub 2024 Apr 5. Haemophilic arthropathy: Diagnosis, management, and aging patient considerations. Bakeer N(1)(2), Saied W(3), Gavrilovski A(4), Bailey C(5). Author information: (1)Indiana Haemophilia and Thrombosis Centre, Indianapolis, Indiana, USA. (2)Children's Hospital of Philadelphi...

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PubMed Narrative Review Evidence Moderate

Management of haemophilic arthropathy.

Haemophilia : the official journal of the World Federation of Hemophilia | 2008 | Bossard D, Carrillon Y, Stieltjes N, Larbre JP

[Indexed for MEDLINE] 11. Haemophilia. 2006 Jul;12 Suppl 3:117-21. doi: 10.1111/j.1365-2516.2006.01268.x. Pathogenesis of haemophilic arthropathy. Roosendaal G(1), Lafeber FP. Author information: (1)University Medical Center Utrecht, Utrecht, The Netherlands. g.roosendaal@umcutrecht.nl The pathogenetic mechanism of haemophilic arthropathy is multifactorial and includes degenera...

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PubMed Narrative Review Evidence Moderate

Pathogenesis of haemophilic arthropathy.

Haemophilia : the official journal of the World Federation of Hemophilia | 2006 | Roosendaal G, Lafeber FP

[Indexed for MEDLINE] 12. Cytokine Growth Factor Rev. 2018 Feb;39:71-91. doi: 10.1016/j.cytogfr.2017.11.003. Epub 2017 Nov 13. Cytokines in the pathogenesis of hemophilic arthropathy. Wojdasiewicz P(1), Poniatowski ŁA(2), Nauman P(3), Mandat T(4), Paradowska-Gorycka A(5), Romanowska-Próchnicka K(6), Szukiewicz D(7), Kotela A(8), Kubaszewski Ł(9), Kotela I(10), Kurkowska-Jastrzę...

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PubMed Narrative Review Evidence Moderate

Hemophilic arthropathy.

The Journal of the American Academy of Orthopaedic Surgeons | 2004 | Luck JV Jr, Silva M, Rodriguez-Merchan EC, Ghalambor N

[Indexed for MEDLINE] 6. Haemophilia. 2008 Jul;14 Suppl 4:3-9. doi: 10.1111/j.1365-2516.2008.01732.x. Physiopathology of haemophilic arthropathy. Lafeber FP(1), Miossec P, Valentino LA. Author information: (1)Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. F.Lafeber@umcutrecht.nl Haemophilic arthropathy, which sha...

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PubMed Original Article Evidence Unclassified

Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US).

Thrombosis and haemostasis | 2013 | Martinoli C, Della Casa Alberighi O, Di Minno G, Graziano E

[Indexed for MEDLINE] 18. Semin Thromb Hemost. 2016 Jul;42(5):541-9. doi: 10.1055/s-0036-1579640. Epub 2016 Apr 28. Assessment of Hemophilic Arthropathy by Ultrasound: Where Do We Stand? Di Minno MN(1), Ambrosino P(1), Quintavalle G(2), Coppola A(1), Tagliaferri A(2), Martinoli C(3), Rivolta GF(2). Author information: (1)Department of Advanced Biomedical Sciences, Division of C...

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