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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Pigmented Villonodular Synovitis (PVNS) / Tenosynovial Giant Cell Tumor (TGCT)
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Systematic Review / Meta-analysis Evidence High

Expression of Molecular Markers Associated with Tenosynovial Giant Cell Tumours and Bone Destruction: A Systematic Review.

Journal of clinical medicine | 2026 | Ward TRW, Zeng F, Ashford RU, Eastley NC

Conflict of interest statement: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. 18. Case Rep Infect Dis. 2021 Aug 14;2021:5523212. doi: 10.1155/2021/5523212. eCollection 2021. Diffuse-Type Tenosyno...

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PubMed Narrative Review Evidence Moderate

Pexidartinib in the Management of Advanced Tenosynovial Giant Cell Tumor: Focus on Patient Selection and Special Considerations.

OncoTargets and therapy | 2022 | Vaynrub A, Healey JH, Tap W, Vaynrub M

Conflict of interest statement: Anna Vaynrub and Max Vaynrub report no conflicts of interest in this work. John Healey has served as a consultant for Daiichi Sankyo and Stryker Consultant, as a trustee for the Musculoskeletal Transplant Foundation, and as a symposium editor for Clinical Orthopaedics and Related Research. William Tap reports personal fees from Eli Lilly, EMD Ser...

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PubMed Narrative Review Evidence Moderate

Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective.

Current oncology reports | 2020 | Bernthal NM, Ishmael CR, Burke ZDC

[Indexed for MEDLINE] 2. Clin Ther. 2016 Apr;38(4):778-93. doi: 10.1016/j.clinthera.2016.03.008. Epub 2016 Apr 1. Patient-reported Symptoms of Tenosynovial Giant Cell Tumors. Gelhorn HL(1), Tong S(2), McQuarrie K(3), Vernon C(3), Hanlon J(3), Maclaine G(4), Lenderking W(3), Ye X(5), Speck RM(3), Lackman RD(6), Bukata SV(7), Healey JH(8), Keedy VL(9), Anthony SP(10), Wagner AJ(1...

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PubMed Narrative Review Evidence Moderate

Locally Aggressive Connective Tissue Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 2018 | Gounder MM, Thomas DM, Tap WD

[Indexed for MEDLINE] 4. Cureus. 2024 Aug 30;16(8):e68248. doi: 10.7759/cureus.68248. eCollection 2024 Aug. Patient Outcomes After Resection of Pigmented Villonodular Synovitis in Patients in King Abdulaziz Medical City. Aljuhani W(1), Alamri A(1), Altorbak B(2), Alabbasi J(3), Ahmed F(4). Author information: (1)Department of Surgery, Ministry of the National Guard - Health Aff...

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PubMed Case Report / Series Evidence Low

Giant Cell Tumor in Tarsal Midfoot Bones: A Case Report.

Cureus | 2024 | Abed Alharbi W, Mohammed Alshareef H, Hennawi YB, Munshi AA

Conflict of interest statement: The authors have declared that no competing interests exist. 10. Onco Targets Ther. 2022 Jan 13;15:53-66. doi: 10.2147/OTT.S345878. eCollection 2022. Pexidartinib in the Management of Advanced Tenosynovial Giant Cell Tumor: Focus on Patient Selection and Special Considerations. Vaynrub A(1), Healey JH(2), Tap W(3), Vaynrub M(2). Author informatio...

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PubMed Case Report / Series Evidence Low

A rare case of long-term joint swelling caused by pigmented villonodular synovitis in a 3-year-old girl: a case report.

Frontiers in surgery | 2023 | Liu Y, Liang S, Wang W

Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 20. JBJS Essent Surg Tech. 2022 May 25;12(2):e21.00035. doi: 10.2106/JBJS.ST.21.00035. eCollection 2022 Apr-Jun. Extensile Anterior and Posterior Knee Exposure for Complete Sy...

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PubMed Narrative Review Evidence Moderate

Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis.

Current opinion in oncology | 2011 | Ravi V, Wang WL, Lewis VO

[Indexed for MEDLINE] 8. BMC Cancer. 2025 Mar 23;25(1):530. doi: 10.1186/s12885-025-13921-7. Tenosynovial giant cell tumours of the foot and ankle: a retrospective single centre experience with surgical treatment of 34 cases. Scheele C(1), Harrasser N(2), Beischl S(2), Dammerer D(3), Lenze U(2), Knebel C(2), von Eisenhart-Rothe R(2), Lenze F(2). Author information: (1)Departmen...

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PubMed Case Report / Series Evidence Low

Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee with Concurrent Polymicrobial Infection (Klebsiella oxytoca and Group B Streptococcus).

Case reports in infectious diseases | 2021 | Marshall JH, Skedros JG, Campana CF, Seibert AM

Conflict of interest statement: The authors declare no conflicts of interest. 19. Front Surg. 2023 May 11;10:1075171. doi: 10.3389/fsurg.2023.1075171. eCollection 2023. A rare case of long-term joint swelling caused by pigmented villonodular synovitis in a 3-year-old girl: a case report. Liu Y(#)(1)(2), Liang S(#)(1), Wang W(1). Author information: (1)Department of Orthopedics,...

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PubMed Original Article Evidence Unclassified

Current management of Tenosynovial Giant Cell Tumours of the knee in the United Kingdom.

The Knee | 2025 | Ward TRW, Ashford RU, Eastley NC

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. 6. BMC Med. 2025 Sep 1;23(1):513. doi: 10.1186/s12916-025-04358-7. Proteomics and metabolomics studies in pigmented villo...

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PubMed Original Article Evidence Unclassified

Proteomics and metabolomics studies in pigmented villonodular synovitis uncover the regulation of monocyte differentiation by the ADGRE5-NF-κB pathway.

BMC medicine | 2025 | Ge M, Yang R, Xu B, Fan L

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate.: The study received approval from the Ethics Committee on Biomedical Research at West China Hospital, Sichuan University (No. 125 2020-(921)). Informed consent was obtained from all participants before their involvement in the study. Consent for publication: Not appli...

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PubMed Original Article Evidence Unclassified

Tenosynovial giant cell tumours of the foot and ankle: a retrospective single centre experience with surgical treatment of 34 cases.

BMC cancer | 2025 | Scheele C, Harrasser N, Beischl S, Dammerer D

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: Approval of local ethics committee (TU Munich) was obtained (no. 2023-103-S-KH). All patients signed an informed consent form. Consent for publication: All authors agreed to publish. Competing interests: The authors declare no competing interests. 9. Cureus. 2024 Mar...

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PubMed Original Article Evidence Unclassified

Mechanistic Study of CD90-Positive Synovial Fibroblasts in the Invasion and Recurrence of Pigmented Villonodular Synovitis.

Journal of inflammation research | 2025 | Kong L, Chen H, Zhang H, Zhang X

Conflict of interest statement: The authors declare that they have no competing interests. 17. J Clin Med. 2026 Mar 15;15(6):2238. doi: 10.3390/jcm15062238. Expression of Molecular Markers Associated with Tenosynovial Giant Cell Tumours and Bone Destruction: A Systematic Review. Ward TRW(1)(2), Zeng F(2), Ashford RU(1)(2), Eastley NC(1)(2), Wang N(2). Author information: (1)Ort...

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PubMed Original Article Evidence Unclassified

Patient Outcomes After Resection of Pigmented Villonodular Synovitis in Patients in King Abdulaziz Medical City.

Cureus | 2024 | Aljuhani W, Alamri A, Altorbak B, Alabbasi J

Conflict of interest statement: Human subjects: Consent was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared th...

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PubMed Case Report / Series Evidence Low

Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study.

Ortopedia, traumatologia, rehabilitacja | 2017 | Kokoszka P, Woźniak W, Łapaj Ł, Kruczyński J

[Indexed for MEDLINE] 12. Oncol Rep. 2000 Mar-Apr;7(2):413-9. Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. Martin RC 2nd(1), Osborne DL, Edwards MJ, Wrightson W, McMasters KM. Author information: (1)Division of Surgical Oncology, Department of Surgery, Universi...

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PubMed Case Report / Series Evidence Low

Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report.

Brazilian dental journal | 2017 | Anbinder AL, Geraldo BMC, Guimarães R Filho, Pereira DL

[Indexed for MEDLINE] 14. Cancer. 2012 Mar 15;118(6):1649-55. doi: 10.1002/cncr.26409. Epub 2011 Aug 5. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. Cassier PA(1), Gelderblom H, Stacchiotti S, Thomas D, Maki RG, Kroep JR, van der Graaf WT, Italiano A, Seddon B, Dômont J, Bom...

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Crossref Journal Article Evidence Unclassified

Clinical benefit of imatinib in patients with relapsed tenosynovial giant cell tumor/pigmented villonodular synovitis (TGCT/PVNS).

Journal of Clinical Oncology | 2022 | Jeanette Cu Yu, Manpreet Kaur Sidhu, Andrew Fang, Lee Jae Morse

e23561 Background: TGCT/PVNS is an uncommon benign but locally aggressive tumor that affects joints and can lead to significant morbidity. It is characterized in most cases by a t(1;2) translocation that leads to overexpression of colony-stimulating factor 1 (CSF-1) and the accumulation of inflammatory cells that express CSF-1 receptor (CSF-1R) in the affected joints. Imatinib...

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PubMed Original Article Evidence Unclassified

Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA | 2018 | Kim DE, Kim JM, Lee BS, Kim NK

[Indexed for MEDLINE] 16. J Inflamm Res. 2025 Dec 8;18:17129-17142. doi: 10.2147/JIR.S549953. eCollection 2025. Mechanistic Study of CD90-Positive Synovial Fibroblasts in the Invasion and Recurrence of Pigmented Villonodular Synovitis. Kong L(#)(1), Chen H(#)(1), Zhang H(#)(2), Zhang X(3), Chen J(1), Nie Y(1), Su Z(1), Lin L(1). Author information: (1)Department of Joint and Or...

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PubMed Original Article Evidence Unclassified

Patient-reported Symptoms of Tenosynovial Giant Cell Tumors.

Clinical therapeutics | 2016 | Gelhorn HL, Tong S, McQuarrie K, Vernon C

[Indexed for MEDLINE] Conflict of interest statement: CONFLICTS OF INTEREST G. Maclaine and X. Ye are employees of Daiichi Sankyo Development Ltd, which provided financial support for this research. S. Tong and P. Lin are employees of Plexxikon Inc, which provided financial support for this research. J.H. Healey is a paid consultant of Daiichi Sankyo Development Ltd. H. Hsu is...

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PubMed Narrative Review Evidence Moderate

Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence.

Oncology reports | 2000 | Martin RC 2nd, Osborne DL, Edwards MJ, Wrightson W

[Indexed for MEDLINE] 13. Braz Dent J. 2017 Sep-Oct;28(5):647-652. doi: 10.1590/0103-6440201701371. Chondroid Tenosynovial Giant Cell Tumor of the Temporomandibular Joint: A Rare Case Report. Anbinder AL(1), Geraldo BMC(1), Guimarães R Filho(2), Pereira DL(3), Almeida OP(3), Carvalho YR(1). Author information: (1)Department of Biosciences and Oral Diagnosis, Institute of Scienc...

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PubMed Original Article Evidence Unclassified

Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

Cancer | 2012 | Cassier PA, Gelderblom H, Stacchiotti S, Thomas D

[Indexed for MEDLINE] 15. Knee Surg Sports Traumatol Arthrosc. 2018 Nov;26(11):3508-3514. doi: 10.1007/s00167-018-4942-2. Epub 2018 Apr 10. Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. Kim DE(1), Kim JM(2)(3), Lee BS(4), Kim NK(5), Lee SH(4), Bin SI(4). Author information: (1)Hospital RU...

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Crossref Journal Article Evidence Unclassified

Tenosynovial giant cell tumor (TGCT)/pigmented villonodular synovitis (PVNS): Outcome of 313 patients before the era of kinase inhibitors.

Journal of Clinical Oncology | 2012 | Emanuela Palmerini, Stefano Pengo, Robert G. Maki, Eric L. Staals

10022 Background: Tenosynovial giant cell tumor (TGCT) is a rare, usually benign neoplasm of synovium and tendon sheath. TGCT is classified as localized or diffuse according to the extent of synovial involvement. Surgery is the primary treatment, but the recurrence rate is high, with possible multiple recurrences, joint function deterioration and decline in quality of life. Rec...

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