Orthonotes
Orthonotes
by the.bonestories
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v3.5 Fusion Pro
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Bone Grafts and Substitutes

Autograft is gold standard: osteogenic + osteoinductive + osteoconductive (iliac crest). Allograft provides scaffold (osteoconductive) ± growth factors; immune & disease transmission risks minimized by processing. Substitutes: calcium phosphates (HA/TCP), calcium sulfate, bioactive glass; mainly osteoconductive. Biologics: BMP‑2/7, PRP (controversial), bone marrow aspirate concentrate. Applications: nonunion, defects, spinal fusion; match graft biology to defect needs.

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Autograft is gold standard: osteogenic + osteoinductive + osteoconductive (iliac crest). Allograft provides scaffold (osteoconductive) ± growth factors; immune & disease transmission risks minimized by processing. Substitutes: calcium phosphates (HA/TCP), calcium sulfate, bioactive glass; mainly osteoconductive. Biologics: BMP‑2/7, PRP (controversial), bone marrow aspirate concentrate. Applications: nonunion, defects, spinal fusion; match graft biology to defect needs.
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