Orthonotes
Orthonotes
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Haemophilic Arthropathy

Caused by recurrent hemarthrosis in hemophilia A/B leading to synovitis, cartilage loss, and arthritis. Target joints: knee, ankle, elbow—recurrent bleeds produce synovial hypertrophy. Radiographic findings: squaring of patella, widened intercondylar notch, subchondral cysts. MRI: sensitive for synovial hypertrophy, hemosiderin deposition, and cartilage thinning. Treatment: prophylactic factor replacement, radiosynovectomy/arthroscopic synovectomy, arthroplasty in end‑stage.

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Caused by recurrent hemarthrosis in hemophilia A/B leading to synovitis, cartilage loss, and arthritis. Target joints: knee, ankle, elbow—recurrent bleeds produce synovial hypertrophy. Radiographic findings: squaring of patella, widened intercondylar notch, subchondral cysts. MRI: sensitive for synovial hypertrophy, hemosiderin deposition, and cartilage thinning. Treatment: prophylactic factor replacement, radiosynovectomy/arthroscopic synovectomy, arthroplasty in end‑stage.
MCQs

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Question 1

What is the primary pathological process in haemophilic arthropathy?

Question 2

Which of the following joints is most commonly affected in haemophilic arthropathy?

Question 3

In the Arnold-Hilgartner classification, what characteristic is observed in Grade IV haemophilic arthropathy?

Question 4

Which treatment is considered the standard of care for preventing arthropathy in patients with severe hemophilia?

Question 5

What radiographic finding is characteristic of early-stage haemophilic arthropathy?

Question 6

Which of the following treatments is indicated for patients with significant synovial hypertrophy in haemophilic arthropathy?

Question 7

What is the role of MRI in evaluating haemophilic arthropathy?

Question 8

What is the major complication associated with on-demand factor replacement therapy in patients with haemophilia?

Question 9

What is the typical incidence of haemophilia A in male births?

Question 10

Which of the following is a common clinical feature of advanced haemophilic arthropathy?