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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Ewing’s Sarcoma — Protocols
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Randomized Controlled Trial Evidence High

Intensified Induction Therapy for Newly Diagnosed, Localized Skeletal Ewing Sarcoma (ISG/AIEOP EW-1): A Randomized, Open-Label, Phase 3, Non-Inferiority Trial.

Pediatric blood & cancer | 2025 | Luksch R, Palmerini E, Milano GM, Paioli A

[Indexed for MEDLINE] 15. Radiother Oncol. 2024 Jun;195:110270. doi: 10.1016/j.radonc.2024.110270. Epub 2024 Apr 5. Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study. Bronk JK(1), McAleer MF(2), McGovern SL(2), Lassen-Ramshad Y(3), Safwat A(3), Daw NC(4), Rainusso N(5), Mahajan A(6), Grosshans DR(2), Paulino AC(7). Author information...

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PubMed Guideline / Consensus Evidence High

Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board.

Cancer | 2024 | Gupta A, Dietz MS, Riedel RF, Dhir A

[Indexed for MEDLINE] 13. Nat Rev Dis Primers. 2022 Oct 6;8(1):66. doi: 10.1038/s41572-022-00393-3. Small round cell sarcomas. Cidre-Aranaz F(1)(2), Watson S(3)(4), Amatruda JF(5)(6), Nakamura T(7), Delattre O(4), de Alava E(8)(9), Dirksen U(10), Grünewald TGP(11)(12)(13). Author information: (1)Division of Translational Paediatric Sarcoma Research, German Cancer Research Cente...

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PubMed Guideline / Consensus Evidence High

Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board.

Cancer | 2023 | Gupta A, Riedel RF, Shah C, Borinstein SC

[Indexed for MEDLINE] 5. Gan To Kagaku Ryoho. 2007 Feb;34(2):175-80. [Ewing sarcoma]. [Article in Japanese] Hamanoue S(1), Makimoto A. Author information: (1)Division of Pediatrics, National Cancer Center Hospital. Ewing sarcoma is the second most frequent primary bone cancer affecting children or young adults. Advances in molecular biology have revealed common chromosomal tran...

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PubMed Randomized Controlled Trial Evidence High

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.

Lancet (London, England) | 2022 | Brennan B, Kirton L, Marec-Bérard P, Gaspar N

[Indexed for MEDLINE] Conflict of interest statement: Declaration of interests SS has received honoraria and consulting fees from GSK, Lilly, and Ceridwen Oncology. JM-B reports institutional grants from Adaptimmune, Amgen, AROG, Bayer, Blueprint, Bristol Myers Squibb, Celgene, Daichii-Sankyo, Deciphera, Eisai, FORMA, GSK, IMMIX Biopharma, Karyopharm, Lilly, Nektar, Novartis, P...

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PubMed Cohort / Comparative Study Evidence Moderate

Prognostic Factors and Clinical Outcomes in Extraskeletal Ewing Sarcoma: A Cohort Study.

Annals of surgical oncology | 2023 | Mathew J, Arjunan R, Dasappa A, Namachivayam A

[Indexed for MEDLINE] 10. J Egypt Natl Canc Inst. 2024 Aug 19;36(1):25. doi: 10.1186/s43046-024-00232-4. Prognostic factors and outcome of relapsed/progressive pediatric Ewing sarcoma: single-center 10-year experience. Arafah O(1), Hegazy RR(2)(3), Ayadi ME(2)(3), Nasr AM(4)(5), Fawzy M(2)(3). Author information: (1)Department of Pediatric Oncology, National Cancer Institute, C...

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PubMed Narrative Review Evidence Moderate

Small round cell sarcomas.

Nature reviews. Disease primers | 2022 | Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T

[Indexed for MEDLINE] 14. Pediatr Blood Cancer. 2025 Apr;72(4):e31551. doi: 10.1002/pbc.31551. Epub 2025 Jan 20. Intensified Induction Therapy for Newly Diagnosed, Localized Skeletal Ewing Sarcoma (ISG/AIEOP EW-1): A Randomized, Open-Label, Phase 3, Non-Inferiority Trial. Luksch R(1), Palmerini E(2), Milano GM(3), Paioli A(2), Asaftei S(4), Barretta F(1), Puma N(1), Cesari M(2)...

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PubMed Case Report / Series Evidence Low

Extraskeletal Ewing's sarcoma of the mediastinum: Case report.

Frontiers in oncology | 2023 | Caltavituro A, Buonaiuto R, Salomone F, Morra R

Conflict of interest statement: SDP reports consulting fees for Consulting or advisory Role: Lilly, GSK, MSD, Seagen, Daichii Sankyo, Gilead, Eisai, Bristol Myers Squibb, AstraZeneca, Novartis, Pfizer, Roche; and Speaker’s Bureau: AstraZeneca, Novartis, Pfizer, Roche. MG reports consulting fees for Consulting or advisory Role: Lilly, Novartis, Pfizer, AstraZeneca; Speaker’s Bur...

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PubMed Original Article Evidence Unclassified

Interest of a sequential multimodal approach for the treatment of newly diagnosed patients with multimetastatic Ewing sarcoma: results of the French prospective CombinaiR3 phase II trial.

British journal of cancer | 2026 | Laurence V, Jehanno N, Dureau S, Mous L

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: PB has consulting role (institutional funding) for Recordati and Merck, drugs for trials from Bayer, participation in educational activities organised by Recordati and is Member of the Executive Committee of the SIOPEN (European neuroblastoma research cooperative group), organisation which receives royal...

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PubMed Narrative Review Evidence Moderate

Ewing's sarcoma.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists | 2010 | Karosas AO

[Indexed for MEDLINE] 4. Cancer. 2023 Nov 1;129(21):3363-3371. doi: 10.1002/cncr.34942. Epub 2023 Jul 5. Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board. Gupta A(1), Riedel RF(2), Shah C(3), Borinstein SC(4), Isakoff MS(5), Chugh R(6), Rosenblum JM(7), Murphy ES(3), Campbell SR(3), Albert CM(8), Zahler S(9), Thomas SM(9),...

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PubMed Original Article Evidence Unclassified

Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis.

Oncogene | 2025 | Adnani M, Hong SH, Galli S, Mahajan A

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare no competing interests. Ethics approval: All methods were performed in accordance with the relevant guidelines and regulations. Procedures involved in animal studies were approved by the Georgetown University Institutional Animal Care and Use Committee (Protocol # 2016-1137) and the G...

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PubMed Original Article Evidence Unclassified

Ewing sarcoma of the sphenoid bone: illustrative case.

Journal of neurosurgery. Case lessons | 2025 | Bassi Y, Alhabib RK, Alsharif TH, Algahtani AY

19. Medicina (B Aires). 2020;80(1):23-30. [Ewing sarcoma of the bone. Multidisciplinary approach and oncological results in 88 patients]. [Article in Spanish; Abstract available in Spanish from the publisher] Sanchez-Saba JE(1), Abrego MO(1), Albergo JI(2), Farfalli GL(1), Aponte-Tinao LA(1), Ayerza MA(1), Cayol F(3), Streitenberger P(4), Risk MR(5), Roitman PD(6). Author infor...

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PubMed Original Article Evidence Unclassified

Prognostic factors and outcome of relapsed/progressive pediatric Ewing sarcoma: single-center 10-year experience.

Journal of the Egyptian National Cancer Institute | 2024 | Arafah O, Hegazy RR, Ayadi ME, Nasr AM

[Indexed for MEDLINE] Conflict of interest statement: Dr Mohamed Fawzy is a co-author of this study and an associate editor of the journal. He has not been involved in handling this manuscript during the review process. The rest of the authors have no conflict of interest to declare. 11. Methods Mol Biol. 2022;2373:283-296. doi: 10.1007/978-1-0716-1693-2_17. 3D Biofabricated In...

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PubMed Original Article Evidence Unclassified

Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | 2024 | Bronk JK, McAleer MF, McGovern SL, Lassen-Ramshad Y

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. 16. Lancet. 2022 Oct 29;400(10362):1513-1521. doi: 10.1016/S0140-6736(22)01790-1. Comparison of two chemotherapy regimens...

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PubMed Original Article Evidence Unclassified

Modeling Ewing Sarcoma Lung Metastasis.

Current protocols | 2023 | Dasgupta A, Kurenbekova L, Patel TD, Rajapakshe K

[Indexed for MEDLINE] Conflict of interest statement: CONFLICT OF INTEREST STATEMENT: No conflict of interest to declare. 3. Am J Health Syst Pharm. 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. Ewing's sarcoma. Karosas AO(1). Author information: (1)Geisinger Medical Center, Danville, PA 17822, USA. akarosas@geisinger.edu PURPOSE: The current treatments of and new therap...

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PubMed Original Article Evidence Unclassified

Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases.

Balkan journal of medical genetics : BJMG | 2023 | Ioannidou M, Tsotridou E, Samoladas E, Tragiannidis A

Conflict of interest statement: Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. 18. J Neurosurg Case Lessons. 2025 Sep 22;10(12):CASE25427. doi: 10.3171/CASE25427. Print 2025 Sep 22. Ewing sarcoma of the sphenoid bone: illustrative case. Bassi Y(1), Alhabib RK(2), Alsharif TH(3)...

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PubMed Original Article Evidence Unclassified

3D Biofabricated In Vitro Models of Vascularized and Mineralized Bone Tissues.

Methods in molecular biology (Clifton, N.J.) | 2022 | Colombo MV, Bersini S, Arrigoni C, Moretti M

[Indexed for MEDLINE] 12. Cancer. 2024 Dec 1;130(23):4028-4039. doi: 10.1002/cncr.35537. Epub 2024 Aug 25. Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board. Gupta A(1)(2), Dietz MS(3), Riedel RF(4), Dhir A(5), Borinstein SC(6), Isakoff MS(7), Aye JM(8), Rainusso N(9), Armstrong AE(...

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PubMed Original Article Evidence Unclassified

[Ewing sarcoma of the bone. Multidisciplinary approach and oncological results in 88 patients].

Medicina | 2020 | Sanchez-Saba JE, Abrego MO, Albergo JI, Farfalli GL

[Indexed for MEDLINE] 20. Br J Cancer. 2026 Jan;134(2):279-288. doi: 10.1038/s41416-025-03263-3. Epub 2025 Nov 17. Interest of a sequential multimodal approach for the treatment of newly diagnosed patients with multimetastatic Ewing sarcoma: results of the French prospective CombinaiR3 phase II trial. Laurence V(1), Jehanno N(2), Dureau S(3), Mous L(4), Claude L(5), Ballet S(6)...

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PubMed Original Article Evidence Unclassified

Ewing sarcoma during follow-up.

Nuklearmedizin. Nuclear medicine | 2017 | Heinemann M, Ranft A, Jürgens H, Langer T

[Indexed for MEDLINE] Conflict of interest statement: The authors have nothing to disclose. 7. Oncogene. 2025 Sep;44(36):3350-3363. doi: 10.1038/s41388-025-03493-y. Epub 2025 Jul 17. Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis. Adnani M(1), Hong SH(1), Galli S(1), Mahajan A(1), Lu C(1)(2), Abualsau...

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PubMed Original Article Evidence Unclassified

[Ewing sarcoma].

Gan to kagaku ryoho. Cancer & chemotherapy | 2007 | Hamanoue S, Makimoto A

[Indexed for MEDLINE] 6. Nuklearmedizin. 2017;56(6):233-238. doi: 10.3413/Nukmed-0909-17-07. Epub 2018 Jan 11. Ewing sarcoma during follow-up. [Article in English] Heinemann M, Ranft A, Jürgens H, Langer T, Vieth V, Timmermann B, Weckesser M, Dirksen U, Stegger L. AIM: To evaluate the performance of a prospectively defined follow-up imaging protocol that includes FDG-PET(/CT) t...

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PubMed Original Article Evidence Unclassified

[Ewing's sarcoma].

Gan to kagaku ryoho. Cancer & chemotherapy | 2004 | Goto T, Hozumi T, Kondo T

[Indexed for MEDLINE] 2. Curr Protoc. 2023 Feb;3(2):e670. doi: 10.1002/cpz1.670. Modeling Ewing Sarcoma Lung Metastasis. Dasgupta A(1), Kurenbekova L(1), Patel TD(1), Rajapakshe K(2), Ghosal G(3), Nirala B(1), Coarfa C(4)(5), Yustein J(1). Author information: (1)Texas Children's Cancer and Hematology Centers and The Faris D. Virani Ewing Sarcoma Center, Baylor College of Medici...

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