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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Musculoskeletal Infections — Algorithm
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Guideline / Consensus Evidence High

The 2020 NBA Orthobiologics Consensus Statement.

Orthopaedic journal of sports medicine | 2021 | Cole BJ, Gilat R, DiFiori J, Rodeo SA

Conflict of interest statement: One or more of the authors has declared the following potential conflict of interest or source of funding: B.J.C. has received research support from Aesculap/B. Braun, Arthrex, and Regentis; royalties from Arthrex, DJO, and Elsevier; consulting fees from Acumed, Arthrex, Bioventus, Flexion Therapeutics, Geistlich Pharma, Regentis, Smith & Nephew,...

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PubMed Narrative Review Evidence Moderate

The Use of Artificial Intelligence in Writing Scientific Review Articles.

Current osteoporosis reports | 2024 | Kacena MA, Plotkin LI, Fehrenbacher JC

[Indexed for MEDLINE] Conflict of interest statement: Dr. Kacena is Editor-in-Chief of Current Osteoporosis Reports. Drs. Fehrenbacher and Plotkin are Section Editors for Current Osteoporosis Reports. 3. Infection. Morrison WB(1), Kransdorf MJ(2). In: Hodler J(3), Kubik-Huch RA(4), von Schulthess GK(5), editors. Musculoskeletal Diseases 2021-2024: Diagnostic Imaging [Internet]....

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PubMed Narrative Review Evidence Moderate

Skeletal infections: microbial pathogenesis, immunity and clinical management.

Nature reviews. Microbiology | 2022 | Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests. 2. Curr Osteoporos Rep. 2024 Feb;22(1):115-121. doi: 10.1007/s11914-023-00852-0. Epub 2024 Jan 16. The Use of Artificial Intelligence in Writing Scientific Review Articles. Kacena MA(1)(2)(3)(4), Plotkin LI(5)(6)(7), Fehrenbacher JC(8)(9)(10). Author information: (1)Department of O...

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PubMed Narrative Review Evidence Moderate

Infection.

Journal unavailable | 2021 | Hodler J, Kubik-Huch RA, von Schulthess GK, Morrison WB

4. J Surg Orthop Adv. 2021 Winter;30(4):212-215. Diagnosis of Prosthetic Joint Infection. Jiranek W(1), Surace P(1). Author information: (1)Duke University, Department of Orthopaedic Surgery, Durham, North Carolina. An 81-year-old male with an infected aortic valve presents to the orthopaedic service with a painful total knee of unclear chronicity and several weeks of intraveno...

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PubMed Narrative Review Evidence Moderate

Comprehensive treatment algorithm of postoperative spinal implant infection.

Journal of spine surgery (Hong Kong) | 2020 | Bürger J, Palmowski Y, Pumberger M

Conflict of interest statement: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jss-20-497). The series “Postoperative Spinal Implant Infection” was commissioned by the editorial office without any funding or sponsorship. MP served as the unpaid Guest Editor of the series and serves as an unpaid editor...

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PubMed Narrative Review Evidence Moderate

Infection after fracture fixation.

EFORT open reviews | 2019 | Steinmetz S, Wernly D, Moerenhout K, Trampuz A

Conflict of interest statement: ICMJE Conflict of interest statement: AT reports grants from Zimmer Biomet paid to his institution outside the submitted work and travel/accommodation/meeting expenses unrelated to activities listed paid to him by Biocomposites. OB reports board membership paid to his institution by Orthopaedic Society, EBJIS, AO Trauma Switzerland; consultancy p...

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PubMed Cohort / Comparative Study Evidence Moderate

Infections After Cranial Neurosurgery: Prospective Cohort of 103 Episodes Treated According to a Standardized Algorithm.

World neurosurgery | 2018 | Renz N, Özdirik B, Finger T, Vajkoczy P

[Indexed for MEDLINE] 15. Orthop J Sports Med. 2021 May 6;9(5):23259671211002296. doi: 10.1177/23259671211002296. eCollection 2021 May. The 2020 NBA Orthobiologics Consensus Statement. Cole BJ(1), Gilat R(1)(2), DiFiori J(3), Rodeo SA(3), Bedi A(4). Author information: (1)Midwest Orthopaedics at Rush University Medical Center, Chicago, Illinois, USA. (2)Department of Orthopaedi...

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PubMed Cohort / Comparative Study Evidence Moderate

MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.

The Journal of biological chemistry | 2018 | Shams K, Kurowska-Stolarska M, Schütte F, Burden AD

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflicts of interest with the contents of this article 20. Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Bateman RM(1), Sharpe MD(1), Jagger JE(1), Ellis...

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Crossref Review Article Evidence Moderate

Linezolid in the treatment of orthopaedic bone and joint infections-a systematic literature review

OA Musculoskeletal Medicine | 2013 | K Anagnostakos, P Mosser

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PubMed Case Report / Series Evidence Low

Diagnosis of Prosthetic Joint Infection.

Journal of surgical orthopaedic advances | 2021 | Jiranek W, Surace P

[Indexed for MEDLINE] 5. Int J Surg. 2025 Dec 1;111(12):9431-9448. doi: 10.1097/JS9.0000000000003239. Epub 2025 Oct 7. Construct validation of machine learning models for predicting surgical site infection risk following ankle fracture surgery. Zhang Q(1), Chen G(2), Zhou C(1), Yang J(1), Qin L(1), Chen L(1), Li F(1), Shen Y(1), Huang W(1), Hu N(1), Wu G(3). Author information:...

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Crossref Journal Article Evidence Unclassified

The Gut–Musculoskeletal Axis: Reframing Orthopaedic Disease Through the Microbiome Lens

Nepal Orthopedic Association Journal | 2026 | Bibek Banskota

Orthopaedic practice has traditionally focused on mechanical injury, degeneration, and localized inflammatory processes. Emerging evidence suggests that musculoskeletal health may be significantly influenced by systemic biological networks. Among these, the gut microbiome has gained attention as a key regulator of immune, metabolic, and endocrine pathways influencing bone and j...

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PubMed Original Article Evidence Unclassified

Construct validation of machine learning models for predicting surgical site infection risk following ankle fracture surgery.

International journal of surgery (London, England) | 2025 | Zhang Q, Chen G, Zhou C, Yang J

[Indexed for MEDLINE] 6. J Arthroplasty. 2019 Nov;34(11):2730-2736.e1. doi: 10.1016/j.arth.2019.06.016. Epub 2019 Jun 13. Development and Validation of an Evidence-Based Algorithm for Diagnosing Periprosthetic Joint Infection. Shohat N(1), Tan TL(2), Della Valle CJ(3), Calkins TE(3), George J(4), Higuera C(4), Parvizi J(2). Author information: (1)Rothman Orthopaedic Institute a...

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PubMed Original Article Evidence Unclassified

Polymicrobial periprosthetic joint infections of the hip and knee : characteristics and management.

The bone & joint journal | 2025 | Margaryan D, Dos Santos MV, Perka C, Trampuz A

[Indexed for MEDLINE] Conflict of interest statement: The authors report a grant from Pro Implant Foundation, related to this study. C. Perka reports royalties or licenses from Zimmer Biomet, Smith & Nephew, and DePuy Synthes, consulting fees and support for attending meetings and/or travel from Zimmer Biomet, Smith & Nephew, Link, and DePuy Synthes, all of which are unrelated...

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PubMed Original Article Evidence Unclassified

Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries.

Journal of clinical epidemiology | 2025 | López-Güell K, Català M, Dedman D, Duarte-Salles T

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest D.P.A.’s department has received grant/s from Amgen, Chiesi–Taylor, Lilly, Janssen, Novartis, and UCB Biopharma. His research group has received consultancy fees from Astra Zeneca and UCB Biopharma. Amgen, Astellas, Janssen, Synapse Management Partners and UCB Biopharma have funded or suppor...

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PubMed Original Article Evidence Unclassified

A Machine Learning Approach to Microcalorimetric Pattern Classification of Pathogens in Synovial Fluid.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society | 2025 | Lozano-García M, Estrada-Petrocelli L, Román RR, Jané R

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest. 19. J Biol Chem. 2018 Feb 23;293(8):3003-3012. doi: 10.1074/jbc.M117.809780. Epub 2017 Dec 26. MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Shams K(1), Kurowska-Stolarska M(2), Schütte F(3), Burden AD(4), McK...

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Crossref Scholarly Work Evidence Unclassified

Imaging of Post-Traumatic and Orthopedic Hardware-Related Appendicular Musculoskeletal Infections

Medical Radiology | 2025 | Matthieu Van Herck, Filip Vanhoenacker, Wouter Huysse, Koenraad Verstraete

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Crossref Journal Article Evidence Unclassified

Orthoregeneration in Modern Orthopedic: Biological Strategies for Musculoskeletal Repair and Regeneration

Journal of Orthopaedic Science and Research | 2025 | Bilal Mohamad Ali Obeid

Orthoregeneration has emerged as a transformative paradigm in regenerative medicine, shifting the focus from mechanical interventions to biologically driven strategies for musculoskeletal tissue repair. This approach leverages the therapeutic potential of Mesenchymal Stem Cells (MSCs), growth factors and bioengineered scaffolds to overcome the inherent limitations of traditiona...

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Crossref Scholarly Work Evidence Unclassified

Diagnostic Algorithm of Appendicular Musculoskeletal Infections

Medical Radiology | 2025 | Yet Yen Yan, Peter L. Munk, Wilfred C. G. Peh

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PubMed Original Article Evidence Unclassified

A predictive algorithm for perioperative complications and readmission after ankle arthrodesis.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2024 | Shah AA, Devana SK, Lee C, SooHoo NF

[Indexed for MEDLINE] 9. EFORT Open Rev. 2019 Jul 15;4(7):468-475. doi: 10.1302/2058-5241.4.180093. eCollection 2019 Jul. Infection after fracture fixation. Steinmetz S(1), Wernly D(1), Moerenhout K(1), Trampuz A(2), Borens O(1). Author information: (1)Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland. (2)Charité - Universitätsmedizin...

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PubMed Original Article Evidence Unclassified

Periprosthetic Joint Infections of the Knee-Comparison of Different Treatment Algorithms.

Journal of clinical medicine | 2024 | Springorum HR, Baier C, Maderbacher G, Paulus A

Conflict of interest statement: The authors declare no conflict of interest. 17. Bone Jt Open. 2020 Nov 1;1(6):309-315. doi: 10.1302/2633-1462.16.BJO-2020-0067.R1. eCollection 2020 Jun. Dealing with the COVID-19 pandemic in orthopaedics: experiences and procedure in Germany. Mueller M(1), Boettner F(2), Karczewski D(1), Janz V(3), Felix S(4), Kramer A(5), Wassilew GI(3). Author...

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Crossref Journal Article Evidence Unclassified

Understanding Orthopaedic Infections: A Conceptual Approach

Orthopedic Reviews | 2024 | Gregory Laborde, Christopher Bloise, George Karam

Background Memorizing mounds of facts without having an effective conceptual framework to store them is often an unsuccessful learning style because memory frequently fails without understanding. To accomplish this goal, we offer a framework of ideas called “concept maps”. Of the many strategies for metacognition (that is, thinking about thinking), concept mapping is proven to...

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Crossref Scholarly Work Evidence Unclassified

Surgical Site Infections in Pediatric Orthopedic Surgery

Pediatric Musculoskeletal Infections | 2022 | Aditya Thandoni, Martin J. Herman

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PubMed Original Article Evidence Unclassified

Improving Care and Outcomes for Pediatric Musculoskeletal Infections.

Pediatrics | 2021 | Hester GZ, Nickel AJ, Watson D, Swanson G

[Indexed for MEDLINE] Conflict of interest statement: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. 12. J Clin Epidemiol. 2025 Sep;185:111867. doi: 10.1016/j.jclinepi.2025.111867. Epub 2025 Jun 13. Clusters of post-acute COVID-19 symptoms: a latent class analysis across 9 databases and 7 countries. López-Güe...

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PubMed Original Article Evidence Unclassified

Dealing with the COVID-19 pandemic in orthopaedics: experiences and procedure in Germany.

Bone & joint open | 2020 | Mueller M, Boettner F, Karczewski D, Janz V

18. J Orthop Res. 2025 Oct;43(10):1855-1864. doi: 10.1002/jor.70024. Epub 2025 Jul 13. A Machine Learning Approach to Microcalorimetric Pattern Classification of Pathogens in Synovial Fluid. Lozano-García M(1)(2)(3), Estrada-Petrocelli L(4)(5), Román RR(1), Jané R(1)(2)(3), Trampuz A(6)(7), Morgenstern C(6)(8). Author information: (1)Universitat Politècnica de Catalunya-Barcelo...

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Crossref Scholarly Work Evidence Unclassified

Presurgical Staphylococcal Decolonization for Select Orthopedic Surgeries

Musculoskeletal Infections | 2020 | Michelle Doll, Gonzalo Bearman

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PubMed Original Article Evidence Unclassified

Development and Validation of an Evidence-Based Algorithm for Diagnosing Periprosthetic Joint Infection.

The Journal of arthroplasty | 2019 | Shohat N, Tan TL, Della Valle CJ, Calkins TE

[Indexed for MEDLINE] 7. Bone Joint J. 2025 Dec 1;107-B(12):1288-1294. doi: 10.1302/0301-620X.107B12.BJJ-2024-1656.R2. Polymicrobial periprosthetic joint infections of the hip and knee : characteristics and management. Margaryan D(1), Dos Santos MV(1), Perka C(1), Trampuz A(2)(3), Karbysheva S(1). Author information: (1)Charité-Universitätsmedizin Berlin, corporate member of Fr...

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PubMed Original Article Evidence Unclassified

A standardized interdisciplinary algorithm for the treatment of prosthetic joint infections.

The bone & joint journal | 2019 | Karczewski D, Winkler T, Renz N, Trampuz A

[Indexed for MEDLINE] 11. Pediatrics. 2021 Feb;147(2):e20200118. doi: 10.1542/peds.2020-0118. Epub 2021 Jan 7. Improving Care and Outcomes for Pediatric Musculoskeletal Infections. Hester GZ(1), Nickel AJ(2), Watson D(2), Swanson G(3), Laine JC(4)(5), Bergmann KR(6). Author information: (1)Departments of Quality, gabrielle.hester@childrensmn.org. (2)Research Institute, Children...

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Crossref Journal Article Evidence Unclassified

Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

Journal of Orthopaedic Research | 2018 | Bingyun Li, Thomas J. Webster

ABSTRACT There has been a dramatic increase in the emergence of antibiotic‐resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. In the U.S. alone, antibiotic‐resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55–70 billion per year economic impact. Antibiotics a...

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PubMed Original Article Evidence Unclassified

36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

Critical care (London, England) | 2016 | Bateman RM, Sharpe MD, Jagger JE, Ellis CG

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Crossref Journal Article Evidence Unclassified

Surgical Site Infections in Treatment of Musculoskeletal Tumors: Experience from a Single Oncologic Orthopedic Institution

Journal of Orthopedic Oncology | 2016 | Barbara Rossi, Carmine Zoccali

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Crossref Journal Article Evidence Unclassified

Surgical Site Infections in Treatment of Musculoskeletal Tumors: Experience from a Single Oncologic Orthopedic Institution

Journal of Orthopedic Oncology | 2016 | Barbara Rossi, Carmine Zoccali, Luigi Toma, Virginia Ferraresi

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Crossref Journal Article Evidence Unclassified

Musculoskeletal Infections in Immunocompromised Hosts

Orthopedic Clinics of North America | 1991 | P.J. Brennan, M. Pia DeGirolamo

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Crossref Journal Article Evidence Unclassified

Actions and Uses of Antimicrobial Agents in the Treatment of Musculoskeletal Infections

Orthopedic Clinics of North America | 1975 | Conrad J. Wilkowske, Paul E. Hermans

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Crossref Scholarly Work Evidence Unclassified

Orthopaedic Infections

Orthopedic Principles — A Resident's Guide

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Crossref Scholarly Work Evidence Unclassified

The Socio-economic Burden of Musculoskeletal Infections

Infection and Local Treatment in Orthopedic Surgery | K. N. Malizos, L. A. Poultsides

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