Evidence Search

Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis

Archives of Orthopaedic and Trauma Surgery | 2021 | Mu Hu, Xingchen Li, Xiangyang Xu

Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome.

Cartilage | 2018 | Chan KW, Ferkel RD, Kern B, Chan SS

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 10. Case Rep Orthop. 2022 May 16;2022:6946860. doi: 10.1155/2022/6946860. eCollection 2022. Gel-Based Autologous Chondrocyte Implantation in a Patient w...

Gel-Based Autologous Chondrocyte Implantation in a Patient with Noncontained Osteochondral Knee Defect at 9-Year Follow-Up.

Case reports in orthopedics | 2022 | Deliwala U, Sethia SJ

Conflict of interest statement: The authors declare no conflict of interest for this case report. 11. Regen Ther. 2020 Jan 14;14:32-39. doi: 10.1016/j.reth.2019.10.003. eCollection 2020 Jun. Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up. Song JS(1), Hong KT(1), Kim NM(1), Jung JY(1), Park...

Clinical and Radiographic Outcomes of Matrix-Induced Autologous Chondrocyte Implantation in Pediatric Patients with Knee Osteochondral Defects

Orthopaedic Journal of Sports Medicine | 2026 | Matthew Frederickson, Lydia McKeithan, Nicholas Stamatos, Michelle Scott

Background: Cartilage defects are a common source of knee pain in pediatric patients and treatment options range from conservative management to surgical interventions such as fixation, microfracture, osteochondral transplantation, and autologous chondrocyte implantation (ACI) or matrix-induced autologous chondrocyte implantation (MACI). ACI/MACI is an established treatment for...

Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association | 2024 | Kaibara T, Kondo E, Matsuoka M, Iwasaki K

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflicts of interest associated with this manuscript. 19. Am J Sports Med. 2009 Jun;37(6):1083-92. doi: 10.1177/0363546509331419. Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: results at 5 years' fol...

Intraarticular Implantation of Autologous Chondrocytes Placed on Collagen or Polyethersulfone Scaffolds: An Experimental Study in Rabbits.

Polymers | 2023 | Płończak M, Wasyłeczko M, Jakutowicz T, Chwojnowski A

Conflict of interest statement: The authors declare no conflict of interest. 13. J Clin Orthop Trauma. 2019 Jan-Feb;10(1):67-75. doi: 10.1016/j.jcot.2018.03.001. Epub 2018 Mar 3. Microfractures and hydrogel scaffolds in the treatment of osteochondral knee defects: A clinical and histological evaluation. Pipino G(1), Risitano S(2), Alviano F(3), Wu EJ(2), Bonsi L(3), Vaccarisi D...

Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification.

Pharmaceutics | 2023 | Philippe V, Jeannerat A, Peneveyre C, Jaccoud S

Conflict of interest statement: Authors A.J., C.P. and A.L. were employed by LAM Biotechnologies SA (Epalinges, Switzerland) during the production of this work. The remaining authors declare no conflicts of interest. 15. Cartilage. 2021 Jul;12(3):333-343. doi: 10.1177/1947603519841673. Epub 2019 Apr 11. Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies...

Socioeconomic Area Deprivation Negatively Impacts Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI) in the Knee

OrthoMedia | 2023

Implant system for large osteochondral defects.

Bone | 2022 | Lohfeld S, Curtin W, McHugh PE

Conflict of interest statement: Declaration of competing interest Stefan Lohfeld declares that he has no conflict of interest. William Curtin declares that he has no conflict of interest. Peter McHugh declares that he has no conflict of interest. 2. Adv Exp Med Biol. 2022;1401:23-55. doi: 10.1007/5584_2022_717. Articular Cartilage Regeneration in Veterinary Medicine. Voga M(1),...

Articular Cartilage Regeneration in Veterinary Medicine.

Advances in experimental medicine and biology | 2022 | Voga M, Majdic G

[Indexed for MEDLINE] 3. Indian J Radiol Imaging. 2014 Jul;24(3):249-53. doi: 10.4103/0971-3026.137035. Imaging of cartilage repair procedures. Sanghvi D(1), Munshi M(1), Pardiwala D(2). Author information: (1)Department of Radiology, Kokilaben Dhirubhai Ambani Hospital, Andheri (W), Mumbai, Maharashtra, India. (2)Department of Orthopaedics, Kokilaben Dhirubhai Ambani Hospital,...

[Treatment of extensive chondral and osteochondral knee defects with autologous chondrocytes implantation].

Revue medicale suisse | 2022 | Martin R, Laurent A, Applegate LA, Philippe V

[Indexed for MEDLINE] Conflict of interest statement: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article. 7. Indian J Orthop. 2015 Mar-Apr;49(2):155-63. doi: 10.4103/0019-5413.152442. Outcome of combined autologous chondrocyte implantation and anterior cruciate ligament reconstruction. Dhinsa BS(1), Nawaz SZ(1), Gallagher KR(1), Skinner J(1), Briggs...

Corrigendum to “Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects”

Orthopaedic Journal of Sports Medicine | 2022

High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.

Cartilage | 2021 | López-Alcorocho JM, Guillén-Vicente I, Rodríguez-Iñigo E, Navarro R

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 6. Rev Med Suisse. 2022 Dec 14;18(808):2384-2390. doi: 10.53738/REVMED.2022.18.808.2384. [Treatment of extensive chondral and osteochondral knee defects...

Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies Investigating Knee Cartilage Restoration.

Cartilage | 2021 | Sheppard WL, Hinckel BB, Arshi A, Sherman SL

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 16. Radiol Med. 2007 Aug;112(5):722-31. doi: 10.1007/s11547-007-0175-z. Epub 2007 Jul 26. Autologous chondrocyte implantation: prospective MRI evaluatio...

The Illustrative Overlay Autologous Chondrocyte Implantation (Overlay ACI) Technique for Repair of the Extra-Large Osteochondral Defects

The Illustrative Book of Cartilage Repair | 2021 | Deepak Rajkumar Goyal

Management of Large Focal Chondral and Osteochondral Defects in the Knee.

The journal of knee surgery | 2020 | Calcei JG, Ray T, Sherman SL, Farr J

[Indexed for MEDLINE] Conflict of interest statement: S. L. S. reports personal fees from Joint Restoration Foundation, personal fees from Olympus, personal fees from Smith and Nephew, personal fees from Vericel, personal fees from Arthrex, personal fees from ConMed, personal fees from Flexion Therapeutics, personal fees from Vivorte, outside the submitted work.J. F. reports ot...

Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up.

Regenerative therapy | 2020 | Song JS, Hong KT, Kim NM, Jung JY

12. Polymers (Basel). 2023 May 18;15(10):2360. doi: 10.3390/polym15102360. Intraarticular Implantation of Autologous Chondrocytes Placed on Collagen or Polyethersulfone Scaffolds: An Experimental Study in Rabbits. Płończak M(1), Wasyłeczko M(2), Jakutowicz T(3), Chwojnowski A(2), Czubak J(4). Author information: (1)Mazovia Regional Hospital John Paul II, 08-110 Siedlce, Poland....

[Technique of all arthroscopic autologous chondrocyte implantation (ACI) for the treatment of cartilage defects in the knee].

Operative Orthopadie und Traumatologie | 2020 | Schlumberger M, Schuster P, Bülow HJ, Mayer P

[Indexed for MEDLINE]

Matrix-Induced Autologous Chondrocyte Implantation With Autologous Bone Grafting for Osteochondral Lesions of the Femoral Trochlea.

Arthroscopy techniques | 2019 | Jones KJ, Cash BM

9. Cartilage. 2018 Jan;9(1):21-29. doi: 10.1177/1947603516681131. Epub 2016 Dec 1. Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome. Chan KW(1), Ferkel RD(2), Kern B(3), Chan SS(4), Applegate GR(5). Author information: (1)1 California Orthopedic & Sports Medicine, San Francisco, CA, USA. (2)2 Southern California Orthopedic...

Microfractures and hydrogel scaffolds in the treatment of osteochondral knee defects: A clinical and histological evaluation.

Journal of clinical orthopaedics and trauma | 2019 | Pipino G, Risitano S, Alviano F, Wu EJ

14. Pharmaceutics. 2023 Sep 16;15(9):2333. doi: 10.3390/pharmaceutics15092333. Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification. Philippe V(1)(2), Jeannerat A(3), Peneveyre C(3), Jaccoud S(2)(4), Scaletta C(2), Hirt-Burri N(2), Abdel-Sayed P(2)(5), Raffoul W(2), Darwiche S(6)...

Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Orthopaedic Journal of Sports Medicine | 2019 | Takahiro Ogura, Gergo Merkely, Tim Bryant, Carl S. Winalski

Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for restoration of the osteochondral unit and to eva...

Comparison of Clinical Outcomes in the Treatment of Patellofemoral Chondral Defects: Autologous Chondrocyte Implantation versus Fresh Osteochondral Allografts

Orthopaedic Journal of Sports Medicine | 2019 | Nirav K. Patel, Vahe Varzhapetyan, Zaira Chaudhry, Hytham S. Salem

Objectives: The complex environment and the extreme stresses of the patellofemoral joint make chondral defects a challenge to treat. Autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) have been reported as case series in the patellofemoral joint with mixed results. This study compared the clinical outcomes for ACI and OCA treatments for...

Autologous Chondrocyte Implantation (ACI)

Cartilage Restoration | 2018 | Andreas H. Gomoll, Jack Farr

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee.

The American journal of sports medicine | 2016 | Bhattacharjee A, McCarthy HS, Tins B, Roberts S

[Indexed for MEDLINE] 18. J Orthop Sci. 2024 Jan;29(1):207-216. doi: 10.1016/j.jos.2022.12.001. Epub 2023 Jan 9. Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years. Kaibara T(1), Kondo E(2), Matsuoka M(3), Iwasaki K(4), Onodera T(5), Sakamoto K(6), Oda Y(7), Tanei ZI(8), Momma D(9),...

Cell-seeded Autologous Chondrocyte Implantation (cs-ACI) - A Simplified Implantation Technique with Maintained Clinical Outcomes

Orthopaedic Journal of Sports Medicine | 2016 | Luiz Felipe Morlin Ambra, Amy Phan, Marissa Mastrocola, Andreas H. Gomoll

Objectives: The objective of this study was to investigate whether outcomes and failure rate of a simplified ACI technique (cs-ACI) were comparable to those of the more complicated traditional technique of a chondrocyte suspension injected under membrane cover (cACI). Methods: Patients were treated with cACI prior to February 2010. After this date the senior author switched to...

Outcome of combined autologous chondrocyte implantation and anterior cruciate ligament reconstruction.

Indian journal of orthopaedics | 2015 | Dhinsa BS, Nawaz SZ, Gallagher KR, Skinner J

Conflict of interest statement: Conflict of Interest: None. 8. Arthrosc Tech. 2019 Feb 11;8(3):e259-e266. doi: 10.1016/j.eats.2018.10.022. eCollection 2019 Mar. Matrix-Induced Autologous Chondrocyte Implantation With Autologous Bone Grafting for Osteochondral Lesions of the Femoral Trochlea. Jones KJ(1), Cash BM(1). Author information: (1)Division of Sports Medicine and Shoulde...

Imaging of cartilage repair procedures.

The Indian journal of radiology & imaging | 2014 | Sanghvi D, Munshi M, Pardiwala D

Conflict of interest statement: Conflict of Interest: None declared. 4. J Knee Surg. 2020 Dec;33(12):1187-1200. doi: 10.1055/s-0040-1721053. Epub 2020 Dec 1. Management of Large Focal Chondral and Osteochondral Defects in the Knee. Calcei JG(1), Ray T(2), Sherman SL(2), Farr J(3). Author information: (1)Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case...

Paper 240: Autologous Chondrocyte Implantation versus Matrix‐induced Autologous Chondrocyte Implantation for Osteochondral Defects of the Knee Minimum 2 year follow‐up results

Arthroscopy | 2012

Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: results at 5 years' follow-up.

The American journal of sports medicine | 2009 | Gobbi A, Kon E, Berruto M, Filardo G

[Indexed for MEDLINE] 20. Oper Orthop Traumatol. 2020 Dec;32(6):532-544. doi: 10.1007/s00064-020-00657-9. Epub 2020 Mar 10. [Technique of all arthroscopic autologous chondrocyte implantation (ACI) for the treatment of cartilage defects in the knee]. [Article in German] Schlumberger M(1), Schuster P(2)(3), Bülow HJ(2), Mayer P(2), Eichinger M(2)(4), Immendörfer M(2), Richter J(2...

Autologous chondrocyte implantation: prospective MRI evaluation with clinical correlation.

La Radiologia medica | 2007 | Caumo F, Russo A, Faccioli N, Vecchini E

[Indexed for MEDLINE] 17. Am J Sports Med. 2016 May;44(5):1249-59. doi: 10.1177/0363546516631739. Epub 2016 Mar 10. Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. Bhattacharjee A(1), McCarthy HS(1), Tins B(2), Roberts S(1), Kuiper JH(1), Harrison PE(3), Richardson JB(4). Author information: (1)The Robert Jones an...

Results of collagen covered autologous chondrocyte implantation (ACI-C) for symptomatic osteochondral defects in the knee

Injury Extra | 2007 | S.P. Krishnan, J.A. Skinner, W. Bartlett, R.W.J. Carrington

Treatment of Full-thickness Chondral Defects with Autologous Chondrocyte Implantation

Orthopedic Clinics of North America | 2005 | Scott D. Gillogly, Thomas H. Myers

Rehabilitation after Articular Cartilage Repair Procedures: Osteochondral Autograft Transplantation and Autologous Chondrocyte Implantation

Postsurgical Orthopedic Sports Rehabilitation | 1997 | M REINOLD

Autologous chondrocyte implantation (ACI) in the treatment of early Osteoarthritis (OA)

http://isrctn.org/> | James Richardson