Evidence Search

Mid- to long-term outcomes of osteochondral lesions of the talus repair: a systematic review.

Journal of orthopaedic surgery and research | 2025 | Wen J, Syed B, Abed I, Shehabat M

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. 14. Cartilage. 2023 Jun;14(2):220-234. doi: 10.1177/19476035231154507. Epub 2023 Mar 1. In Vitro Comparison of 2 Clinically Applied Biomaterials f...

Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review.

Orthopaedic journal of sports medicine | 2024 | Correia Cardoso R, Andrade R, Monteiro I, Machado C

Conflict of interest statement: The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. 9. J Clin Orthop Trauma. 2022...

Managing Chondral Lesions: A Literature Review and Evidence-Based Clinical Guidelines.

Indian journal of orthopaedics | 2021 | Banerjee S, Sahanand KS

Conflict of interest statement: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest. No financial aid of any nature was obtained from any source for this article. 6. Arthroscopy. 2025 Jun;41(6):1987-1988. doi: 10.1016/j.arthro.2024.10.012. Epub 2024 Oct 18. Editorial Commentary: Offloading Patellofemoral Chondral D...

Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group 'clinical tissue regeneration' of the German Society of Orthopedics and Traumatology (DGOU).

EFORT open reviews | 2024 | Walther M, Gottschalk O, Aurich M

Conflict of interest statement: All authors are members of the Working Group on Tissue Regeneration of the German Association of Orthopedic and Trauma Surgery (DGOU). Markus Walther and Oliver Gottschalk worked as paid speakers at Geistlich workshops. 20. Blood Coagul Fibrinolysis. 2012 Apr;23(3):179-83. doi: 10.1097/MBC.0b013e32835084dd. Cartilage damage in the haemophilic joi...

Clinical Applicability of Autologous Chondrocyte Implantation for the Treatment of Osteochondral Defects: A Meta-analysis

Current Rheumatology Reviews | 2024 | Faisal I. Almohaileb, Zafar Rasheed

Purpose: Osteoarthritis and other joint disorders are the leading cause of disability in the elderly and the treatment of joint lesions is challenging. Autologous chondrocyte implantation (ACI) has been reported with variable effects for the treatment of osteochondral and other joint lesions. In this study, we performed a meta-analysis of the recent literature to determine the...

An evidence-based update on the management of articular cartilage defects in the hip.

Journal of clinical orthopaedics and trauma | 2022 | Sunil Kumar KH, Garner M, Khanduja V

Conflict of interest statement: None. 10. Int Orthop. 2013 Sep;37(9):1697-706. doi: 10.1007/s00264-013-2076-1. Epub 2013 Aug 28. Treatment principles for osteochondral lesions in foot and ankle. Badekas T(1), Takvorian M, Souras N. Author information: (1)Hygeia Hospital Orthopaedic Department, Athens, Greece. Osteochondral lesion of the talus (OLT) is a broad term used to descr...

Scientific Developments and Clinical Applications Utilizing Chondrons and Chondrocytes with Matrix for Cartilage Repair.

Cartilage | 2021 | Shah SS, Mithoefer K

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 12. Knee Surg Sports Traumatol Arthrosc. 2010 Feb;18(2):238-46. doi: 10.1007/s00167-009-0942-6. Epub 2009 Oct 27. Treatment of osteochondral lesions of...

Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis

Archives of Orthopaedic and Trauma Surgery | 2021 | Mu Hu, Xingchen Li, Xiangyang Xu

Treatment of osteochondral lesions of the talus: a systematic review.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA | 2010 | Zengerink M, Struijs PA, Tol JL, van Dijk CN

[Indexed for MEDLINE] 13. J Orthop Surg Res. 2025 Oct 14;20(1):892. doi: 10.1186/s13018-025-06214-z. Mid- to long-term outcomes of osteochondral lesions of the talus repair: a systematic review. Wen J(1), Syed B(2), Abed I(2), Shehabat M(2), Akhtar M(2), Razick D(2), Alam A(3), Kreuelen C(4). Author information: (1)California Northstate University College of Medicine, 9700 W Ta...

Current solutions for the treatment of chronic articular cartilage defects in the knee.

EFORT open reviews | 2020 | Chimutengwende-Gordon M, Donaldson J, Bentley G

Conflict of interest statement: ICMJE Conflict of interest statement: GB reports that he is the Scientific Editor for EFORT Open Reviews, outside the submitted work. The other authors report no conflict of interest relevant to this work. 16. Cartilage. 2021 Dec;13(1_suppl):1298S-1305S. doi: 10.1177/19476035211030991. Epub 2021 Jul 21. Etiology of Cartilage Lesions Does Not Affe...

Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome.

Cartilage | 2018 | Chan KW, Ferkel RD, Kern B, Chan SS

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 18. Z Orthop Unfall. 2011 Jan;149(1):37-44. doi: 10.1055/s-0030-1250059. Epub 2010 Jul 19. [Regeneration of osteochondral defects in the knee]. [Article...

Treatment principles for osteochondral lesions in foot and ankle.

International orthopaedics | 2013 | Badekas T, Takvorian M, Souras N

[Indexed for MEDLINE] 11. Cartilage. 2021 Dec;13(1_suppl):1195S-1205S. doi: 10.1177/1947603520968884. Epub 2020 Nov 6. Scientific Developments and Clinical Applications Utilizing Chondrons and Chondrocytes with Matrix for Cartilage Repair. Shah SS(1), Mithoefer K(1). Author information: (1)Division of Sports Medicine, Department of Orthopaedic Surgery, New England Baptist Hospi...

Cartilage damage in the haemophilic joints: pathophysiology, diagnosis and management.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | 2012 | Rodriguez-Merchan EC

[Indexed for MEDLINE]

[Regeneration of osteochondral defects in the knee].

Zeitschrift fur Orthopadie und Unfallchirurgie | 2011 | Jäger M, Bittersohl B, Zilkens C, Herten M

[Indexed for MEDLINE] 19. EFORT Open Rev. 2024 Mar 5;9(3):217-234. doi: 10.1530/EOR-23-0075. Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group 'clinical tissue regeneration' of the German Society of Orthopedics and Traumatology (DGOU). Walther M(1)(2)(3)(4)(5), Gottschalk O(1)(2)(5), Aurich M(5)(6)(7). Author information: (1)S...

Rehabilitation after autologous chondrocyte implantation in athletes.

Clinics in sports medicine | 2010 | Nho SJ, Pensak MJ, Seigerman DA, Cole BJ

[Indexed for MEDLINE] 2. Bone. 2022 Dec;165:116544. doi: 10.1016/j.bone.2022.116544. Epub 2022 Sep 6. Implant system for large osteochondral defects. Lohfeld S(1), Curtin W(2), McHugh PE(3). Author information: (1)Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA; Biomedical Engineering, School of Engineering, National...

Editorial Commentary: Offloading Patellofemoral Chondral Defects Requires Tailored Tibial Tuberosity Osteotomy Procedures.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2025 | Tanaka MJ

[Indexed for MEDLINE] Conflict of interest statement: Disclosures The author declares the following financial interests/personal relationships which may be considered as potential competing interests: M.J.T. has consulting or advisory relationships with Arthrex, Johnson and Johnson, Vericel, and Verywell Health; is a board member of the American Orthopaedic Society for Sports M...

Autologous chondrocyte implantation, matrix‐induced autologous chondrocyte implantation, osteochondral autograft transplantation and osteochondral allograft improve knee function and pain with considerations for patient and cartilage defects characteristi

Knee Surgery, Sports Traumatology, Arthroscopy | 2025 | Joseph E. Nassar, Grace Guerin, Taidhgin Keel, Raffaella Russo

AbstractPurposePrevious studies have reported on the outcomes of autologous chondrocyte implantation (ACI) versus matrix‐induced ACI (MACI) and microfracture. Specific clinical outcomes of ACI, MACI, osteochondral autograft transplantation (OAT) and osteochondral allograft (OCA) have not been well studied. The purpose of this systematic review and meta‐analysis was to analyze t...

Treatment of osteochondral defects of the talus.

Revue de chirurgie orthopedique et reparatrice de l'appareil moteur | 2008 | van Bergen CJ, de Leeuw PA, van Dijk CN

[Indexed for MEDLINE] 4. J Knee Surg. 2020 Dec;33(12):1187-1200. doi: 10.1055/s-0040-1721053. Epub 2020 Dec 1. Management of Large Focal Chondral and Osteochondral Defects in the Knee. Calcei JG(1), Ray T(2), Sherman SL(2), Farr J(3). Author information: (1)Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio. (2...

Intraarticular Implantation of Autologous Chondrocytes Placed on Collagen or Polyethersulfone Scaffolds: An Experimental Study in Rabbits.

Polymers | 2023 | Płończak M, Wasyłeczko M, Jakutowicz T, Chwojnowski A

Conflict of interest statement: The authors declare no conflict of interest. 8. Orthop J Sports Med. 2024 Dec 3;12(12):23259671241296434. doi: 10.1177/23259671241296434. eCollection 2024 Dec. Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review. Correia Cardoso R(1), Andrade R(2)(3)(4), Monteiro I(1), Machado C(1), Malheiro FS(2)(5)(6), Serr...

In Vitro Comparison of 2 Clinically Applied Biomaterials for Autologous Chondrocyte Implantation: Injectable Hydrogel Versus Collagen Scaffold.

Cartilage | 2023 | Weitkamp JT, Benz K, Rolauffs B, Bayer A

[Indexed for MEDLINE] Conflict of interest statement: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors declare no conflict of interest. PB and MH declare that the clinical products investigated in this study are clinically used by PB and MH. KB is head of the research a...

Socioeconomic Area Deprivation Negatively Impacts Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI) in the Knee

OrthoMedia | 2023

Implant system for large osteochondral defects.

Bone | 2022 | Lohfeld S, Curtin W, McHugh PE

Conflict of interest statement: Declaration of competing interest Stefan Lohfeld declares that he has no conflict of interest. William Curtin declares that he has no conflict of interest. Peter McHugh declares that he has no conflict of interest. 3. Rev Chir Orthop Reparatrice Appar Mot. 2008 Dec;94(8 Suppl):398-408. doi: 10.1016/j.rco.2008.09.003. Epub 2008 Nov 11. Treatment o...

Corrigendum to “Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects”

Orthopaedic Journal of Sports Medicine | 2022

Etiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation.

Cartilage | 2021 | Mestriner AB, Ackermann J, Merkely G, Galvão PHSAF

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 17. Cartilage. 2018 Jan;9(1):21-29. doi: 10.1177/1947603516681131. Epub 2016 Dec 1. Correlation of MRI Appearance of Autologous Chondrocyte Implantation...

The Illustrative Overlay Autologous Chondrocyte Implantation (Overlay ACI) Technique for Repair of the Extra-Large Osteochondral Defects

The Illustrative Book of Cartilage Repair | 2021 | Deepak Rajkumar Goyal

Management of Large Focal Chondral and Osteochondral Defects in the Knee.

The journal of knee surgery | 2020 | Calcei JG, Ray T, Sherman SL, Farr J

[Indexed for MEDLINE] Conflict of interest statement: S. L. S. reports personal fees from Joint Restoration Foundation, personal fees from Olympus, personal fees from Smith and Nephew, personal fees from Vericel, personal fees from Arthrex, personal fees from ConMed, personal fees from Flexion Therapeutics, personal fees from Vivorte, outside the submitted work.J. F. reports ot...

Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Orthopaedic Journal of Sports Medicine | 2019 | Takahiro Ogura, Gergo Merkely, Tim Bryant, Carl S. Winalski

Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for restoration of the osteochondral unit and to eva...

Comparison of Clinical Outcomes in the Treatment of Patellofemoral Chondral Defects: Autologous Chondrocyte Implantation versus Fresh Osteochondral Allografts

Orthopaedic Journal of Sports Medicine | 2019 | Nirav K. Patel, Vahe Varzhapetyan, Zaira Chaudhry, Hytham S. Salem

Objectives: The complex environment and the extreme stresses of the patellofemoral joint make chondral defects a challenge to treat. Autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) have been reported as case series in the patellofemoral joint with mixed results. This study compared the clinical outcomes for ACI and OCA treatments for...

Autologous Chondrocyte Implantation (ACI)

Cartilage Restoration | 2018 | Andreas H. Gomoll, Jack Farr

Cell-seeded Autologous Chondrocyte Implantation (cs-ACI) - A Simplified Implantation Technique with Maintained Clinical Outcomes

Orthopaedic Journal of Sports Medicine | 2016 | Luiz Felipe Morlin Ambra, Amy Phan, Marissa Mastrocola, Andreas H. Gomoll

Objectives: The objective of this study was to investigate whether outcomes and failure rate of a simplified ACI technique (cs-ACI) were comparable to those of the more complicated traditional technique of a chondrocyte suspension injected under membrane cover (cACI). Methods: Patients were treated with cACI prior to February 2010. After this date the senior author switched to...

Paper 240: Autologous Chondrocyte Implantation versus Matrix‐induced Autologous Chondrocyte Implantation for Osteochondral Defects of the Knee Minimum 2 year follow‐up results

Arthroscopy | 2012

Results of collagen covered autologous chondrocyte implantation (ACI-C) for symptomatic osteochondral defects in the knee

Injury Extra | 2007 | S.P. Krishnan, J.A. Skinner, W. Bartlett, R.W.J. Carrington

Treatment of Full-thickness Chondral Defects with Autologous Chondrocyte Implantation

Orthopedic Clinics of North America | 2005 | Scott D. Gillogly, Thomas H. Myers

Rehabilitation after Articular Cartilage Repair Procedures: Osteochondral Autograft Transplantation and Autologous Chondrocyte Implantation

Postsurgical Orthopedic Sports Rehabilitation | 1997 | M REINOLD

Autologous chondrocyte implantation (ACI) in the treatment of early Osteoarthritis (OA)

http://isrctn.org/> | James Richardson