Evidence Search

Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review.

Orthopaedic journal of sports medicine | 2024 | Correia Cardoso R, Andrade R, Monteiro I, Machado C

Conflict of interest statement: The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

A systematic review of cartilage procedures for unstable osteochondritis dissecans.

The Physician and sportsmedicine | 2023 | Matthews JR, Sonnier JH, Paul RW, Avendano JP

[Indexed for MEDLINE] 14. Cartilage. 2021 Dec;13(1_suppl):1195S-1205S. doi: 10.1177/1947603520968884. Epub 2020 Nov 6. Scientific Developments and Clinical Applications Utilizing Chondrons and Chondrocytes with Matrix for Cartilage Repair. Shah SS(1), Mithoefer K(1). Author information: (1)Division of Sports Medicine, Department of Orthopaedic Surgery, New England Baptist Hospi...

Managing Chondral Lesions: A Literature Review and Evidence-Based Clinical Guidelines.

Indian journal of orthopaedics | 2021 | Banerjee S, Sahanand KS

Conflict of interest statement: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest. No financial aid of any nature was obtained from any source for this article. 13. Phys Sportsmed. 2023 Dec;51(6):497-505. doi: 10.1080/00913847.2022.2082262. Epub 2022 May 31. A systematic review of cartilage procedures for unstabl...

Scientific Developments and Clinical Applications Utilizing Chondrons and Chondrocytes with Matrix for Cartilage Repair.

Cartilage | 2021 | Shah SS, Mithoefer K

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 15. Curr Rheumatol Rev. 2024;20(3):317-331. doi: 10.2174/0115733971249660231101102757. Clinical Applicability of Autologous Chondrocyte Implantation for...

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering.

Frontiers in bioengineering and biotechnology | 2021 | Zhao X, Hu DA, Wu D, He F

Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 18. Cartilage. 2021 Dec;13(1_suppl):1298S-1305S. doi: 10.1177/19476035211030991. Epub 2021 Jul 21. Etiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofe...

Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis

Archives of Orthopaedic and Trauma Surgery | 2021 | Mu Hu, Xingchen Li, Xiangyang Xu

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques.

Therapeutic advances in musculoskeletal disease | 2019 | Gao Y, Gao J, Li H, Du D

Conflict of interest statement: Conflict of interest statement: The authors declare that there is no conflict of interest. 4. Adv Exp Med Biol. 2022;1401:23-55. doi: 10.1007/5584_2022_717. Articular Cartilage Regeneration in Veterinary Medicine. Voga M(1), Majdic G(2). Author information: (1)Institute for Preclinical Sciences, University of Ljubljana, Ljubljana, Slovenia. (2)In...

MR imaging of cartilage repair surgery of the knee.

Clinical imaging | 2019 | Liu YW, Tran MD, Skalski MR, Patel DB

[Indexed for MEDLINE] 10. Arthroscopy. 2025 Jun;41(6):1987-1988. doi: 10.1016/j.arthro.2024.10.012. Epub 2024 Oct 18. Editorial Commentary: Offloading Patellofemoral Chondral Defects Requires Tailored Tibial Tuberosity Osteotomy Procedures. Tanaka MJ. The presence of patellofemoral chondral defects is common in the setting of patellar instability. Multiple procedures have been...

Correlation of MRI Appearance of Autologous Chondrocyte Implantation in the Ankle with Clinical Outcome.

Cartilage | 2018 | Chan KW, Ferkel RD, Kern B, Chan SS

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 12. Indian J Orthop. 2021 Jan 26;55(2):252-262. doi: 10.1007/s43465-021-00355-z. eCollection 2021 Apr. Managing Chondral Lesions: A Literature Review an...

Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC).

Journal of clinical orthopaedics and trauma | 2016 | Huh SW, Shetty AA, Ahmed S, Lee DH

8. Rev Med Suisse. 2022 Dec 14;18(808):2384-2390. doi: 10.53738/REVMED.2022.18.808.2384. [Treatment of extensive chondral and osteochondral knee defects with autologous chondrocytes implantation]. [Article in French; Abstract available in French from the publisher] Martin R(1), Laurent A(2), Applegate LA(2), Philippe V(1). Author information: (1)Service d'orthopédie et de traum...

Clinical and Radiographic Outcomes of Matrix-Induced Autologous Chondrocyte Implantation in Pediatric Patients with Knee Osteochondral Defects

Orthopaedic Journal of Sports Medicine | 2026 | Matthew Frederickson, Lydia McKeithan, Nicholas Stamatos, Michelle Scott

Background: Cartilage defects are a common source of knee pain in pediatric patients and treatment options range from conservative management to surgical interventions such as fixation, microfracture, osteochondral transplantation, and autologous chondrocyte implantation (ACI) or matrix-induced autologous chondrocyte implantation (MACI). ACI/MACI is an established treatment for...

Editorial Commentary: Offloading Patellofemoral Chondral Defects Requires Tailored Tibial Tuberosity Osteotomy Procedures.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2025 | Tanaka MJ

[Indexed for MEDLINE] Conflict of interest statement: Disclosures The author declares the following financial interests/personal relationships which may be considered as potential competing interests: M.J.T. has consulting or advisory relationships with Arthrex, Johnson and Johnson, Vericel, and Verywell Health; is a board member of the American Orthopaedic Society for Sports M...

Autologous chondrocyte implantation, matrix‐induced autologous chondrocyte implantation, osteochondral autograft transplantation and osteochondral allograft improve knee function and pain with considerations for patient and cartilage defects characteristi

Knee Surgery, Sports Traumatology, Arthroscopy | 2025 | Joseph E. Nassar, Grace Guerin, Taidhgin Keel, Raffaella Russo

AbstractPurposePrevious studies have reported on the outcomes of autologous chondrocyte implantation (ACI) versus matrix‐induced ACI (MACI) and microfracture. Specific clinical outcomes of ACI, MACI, osteochondral autograft transplantation (OAT) and osteochondral allograft (OCA) have not been well studied. The purpose of this systematic review and meta‐analysis was to analyze t...

Socioeconomic Area Deprivation Negatively Impacts Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI) in the Knee

OrthoMedia | 2023

Implant system for large osteochondral defects.

Bone | 2022 | Lohfeld S, Curtin W, McHugh PE

Conflict of interest statement: Declaration of competing interest Stefan Lohfeld declares that he has no conflict of interest. William Curtin declares that he has no conflict of interest. Peter McHugh declares that he has no conflict of interest. 2. Cartilage. 2021 Jul;12(3):307-319. doi: 10.1177/1947603519835898. Epub 2019 Mar 17. High-Density Autologous Chondrocyte Implantati...

Articular Cartilage Regeneration in Veterinary Medicine.

Advances in experimental medicine and biology | 2022 | Voga M, Majdic G

[Indexed for MEDLINE] 5. J Knee Surg. 2020 Dec;33(12):1187-1200. doi: 10.1055/s-0040-1721053. Epub 2020 Dec 1. Management of Large Focal Chondral and Osteochondral Defects in the Knee. Calcei JG(1), Ray T(2), Sherman SL(2), Farr J(3). Author information: (1)Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio. (2...

[Treatment of extensive chondral and osteochondral knee defects with autologous chondrocytes implantation].

Revue medicale suisse | 2022 | Martin R, Laurent A, Applegate LA, Philippe V

[Indexed for MEDLINE] Conflict of interest statement: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article. 9. Clin Imaging. 2019 Nov-Dec;58:129-139. doi: 10.1016/j.clinimag.2019.07.004. Epub 2019 Jul 11. MR imaging of cartilage repair surgery of the knee. Liu YW(1), Tran MD(2), Skalski MR(3), Patel DB(4), White EA(4), Tomasian A(4), Gross JS(4), Vang...

Corrigendum to “Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects”

Orthopaedic Journal of Sports Medicine | 2022

High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.

Cartilage | 2021 | López-Alcorocho JM, Guillén-Vicente I, Rodríguez-Iñigo E, Navarro R

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 3. Ther Adv Musculoskelet Dis. 2019 Sep 23;11:1759720X19877131. doi: 10.1177/1759720X19877131. eCollection 2019. Autologous costal chondral transplantat...

Etiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation.

Cartilage | 2021 | Mestriner AB, Ackermann J, Merkely G, Galvão PHSAF

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 19. Knee Surg Sports Traumatol Arthrosc. 2013 Mar;21(3):671-7. doi: 10.1007/s00167-012-2036-0. Epub 2012 May 3. Autologous chondrocyte implantation in c...

The Illustrative Overlay Autologous Chondrocyte Implantation (Overlay ACI) Technique for Repair of the Extra-Large Osteochondral Defects

The Illustrative Book of Cartilage Repair | 2021 | Deepak Rajkumar Goyal

Management of Large Focal Chondral and Osteochondral Defects in the Knee.

The journal of knee surgery | 2020 | Calcei JG, Ray T, Sherman SL, Farr J

[Indexed for MEDLINE] Conflict of interest statement: S. L. S. reports personal fees from Joint Restoration Foundation, personal fees from Olympus, personal fees from Smith and Nephew, personal fees from Vericel, personal fees from Arthrex, personal fees from ConMed, personal fees from Flexion Therapeutics, personal fees from Vivorte, outside the submitted work.J. F. reports ot...

Matrix-Induced Autologous Chondrocyte Implantation With Autologous Bone Grafting for Osteochondral Lesions of the Femoral Trochlea.

Arthroscopy techniques | 2019 | Jones KJ, Cash BM

17. Front Bioeng Biotechnol. 2021 Mar 25;9:603444. doi: 10.3389/fbioe.2021.603444. eCollection 2021. Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering. Zhao X(1)(2), Hu DA(2), Wu D(2), He F(2)(3)(4), Wang H(2)(5), Huang L(2)(3)(4), Shi D(2)(6), Liu Q(2)(7), Ni N(2)(5), Pakvasa M(2), Zhang Y(1)(2), Fu K(2)(8), Qin KH(2), Li AJ(2), H...

Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Orthopaedic Journal of Sports Medicine | 2019 | Takahiro Ogura, Gergo Merkely, Tim Bryant, Carl S. Winalski

Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for restoration of the osteochondral unit and to eva...

Comparison of Clinical Outcomes in the Treatment of Patellofemoral Chondral Defects: Autologous Chondrocyte Implantation versus Fresh Osteochondral Allografts

Orthopaedic Journal of Sports Medicine | 2019 | Nirav K. Patel, Vahe Varzhapetyan, Zaira Chaudhry, Hytham S. Salem

Objectives: The complex environment and the extreme stresses of the patellofemoral joint make chondral defects a challenge to treat. Autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) have been reported as case series in the patellofemoral joint with mixed results. This study compared the clinical outcomes for ACI and OCA treatments for...

Autologous Chondrocyte Implantation (ACI)

Cartilage Restoration | 2018 | Andreas H. Gomoll, Jack Farr

Outcome of combined autologous chondrocyte implantation and anterior cruciate ligament reconstruction.

Indian journal of orthopaedics | 2015 | Dhinsa BS, Nawaz SZ, Gallagher KR, Skinner J

Conflict of interest statement: Conflict of Interest: None. 7. J Clin Orthop Trauma. 2016 Jul-Sep;7(3):153-6. doi: 10.1016/j.jcot.2016.05.004. Epub 2016 Jun 16. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC). Huh SW(1), Shetty AA(2), Ahmed S(2), Lee DH(1), Kim SJ(1). Author information: (1)Department of Orthopaedic Surgery, College of Medicine, The Cathol...

Autologous chondrocyte implantation in children and adolescents.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA | 2013 | Schmal H, Pestka JM, Salzmann G, Strohm PC

[Indexed for MEDLINE] 20. Orthop J Sports Med. 2024 Dec 3;12(12):23259671241296434. doi: 10.1177/23259671241296434. eCollection 2024 Dec. Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review. Correia Cardoso R(1), Andrade R(2)(3)(4), Monteiro I(1), Machado C(1), Malheiro FS(2)(5)(6), Serrano P(1), Amado P(7)(8)(9)(10)(11)(12)(13), Espregueir...

Paper 240: Autologous Chondrocyte Implantation versus Matrix‐induced Autologous Chondrocyte Implantation for Osteochondral Defects of the Knee Minimum 2 year follow‐up results

Arthroscopy | 2012

Results of collagen covered autologous chondrocyte implantation (ACI-C) for symptomatic osteochondral defects in the knee

Injury Extra | 2007 | S.P. Krishnan, J.A. Skinner, W. Bartlett, R.W.J. Carrington

Treatment of Full-thickness Chondral Defects with Autologous Chondrocyte Implantation

Orthopedic Clinics of North America | 2005 | Scott D. Gillogly, Thomas H. Myers

Rehabilitation after Articular Cartilage Repair Procedures: Osteochondral Autograft Transplantation and Autologous Chondrocyte Implantation

Postsurgical Orthopedic Sports Rehabilitation | 1997 | M REINOLD

Autologous chondrocyte implantation (ACI) in the treatment of early Osteoarthritis (OA)

http://isrctn.org/> | James Richardson