Most common primary malignant bone tumor in adults (median age ~65 yrs). Neoplastic proliferation of plasma cells → monoclonal immunoglobulin production. Classical CRAB features: hyperCalcemia, Renal failure, Anemia, Bone lesions. Radiology: multiple punched-out lytic lesions, diffuse osteopenia. Diagnosis: SPEP/UPEP (M protein, Bence-Jones), bone marrow biopsy (>10% plasma cells). Ortho role: prophylactic fixation of impending fractures (Mirel’s >8), spinal decompression, bisphosphonates, vertebroplasty/kyphoplasty. Systemic therapy: chemo, immunomodulators, stem cell transplant.
What is the most common primary malignant bone tumor in adults?
Which of the following is NOT a CRAB feature of Multiple Myeloma?
What characteristic radiological finding is associated with Multiple Myeloma?
In the management of Multiple Myeloma, which procedure is indicated for impending fractures?
Which laboratory test is primarily used to diagnose Multiple Myeloma?
Which of the following treatments is commonly used to manage hypercalcemia in Multiple Myeloma?
What is the typical age range for the diagnosis of Multiple Myeloma?
What is a common orthopedic complication of Multiple Myeloma?
Which treatment option is NOT typically used in the orthopedic management of Multiple Myeloma?
What is the role of DKK-1 in the pathophysiology of bone destruction in Multiple Myeloma?
