Metastatic Bone Disease
Most common malignant tumor of bone overall. Primary sources: breast, prostate, lung, kidney, thyroid. Lesions: breast (mixed), prostate (blastic), lung/kidney/thyroid (lytic). Sites: spine, pelvis, proximal femur/humerus. Investigations: X-ray, MRI, CT chest/abdomen, bone scan/PET. Management: systemic therapy, bisphosphonates/denosumab, prophylactic fixation (Mirel’s >8), radiotherapy, spinal stabilization.
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2Practised by MCQ
10What is the most common source of metastatic bone disease?
mcqWhich type of metastatic bone lesion is most commonly associated with prostate cancer?
mcqIn which anatomical sites are metastatic bone lesions most commonly found?
mcqWhich imaging modality is most sensitive for detecting metastatic lesions from prostate cancer?
mcqWhat is the Mirels score threshold for recommending prophylactic surgical fixation in metastatic bone disease?
mcqWhich of the following primary cancers is most commonly associated with lytic bone metastases?
mcqWhich systemic therapy is commonly used for treating metastatic bone disease?
mcqWhich of the following is NOT a common complication of metastatic bone disease?
mcqWhat is the primary treatment approach for lytic lesions in metastatic bone disease?
mcqWhich treatment is recommended for renal cell carcinoma bone metastases prior to surgery?