Multiple Myeloma — Orthopaedic View
Most common primary malignant bone tumor in adults (median age ~65 yrs). Neoplastic proliferation of plasma cells → monoclonal immunoglobulin production. Classical CRAB features: hyperCalcemia, Renal failure, Anemia, Bone lesions. Radiology: multiple punched-out lytic lesions, diffuse osteopenia. Diagnosis: SPEP/UPEP (M protein, Bence-Jones), bone marrow biopsy (>10% plasma cells). Ortho role: prophylactic fixation of impending fractures (Mirel’s >8), spinal decompression, bisphosphonates, verte...
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10What is the most common primary malignant bone tumor in adults?
mcqWhich of the following is NOT a CRAB feature of Multiple Myeloma?
mcqWhat characteristic radiological finding is associated with Multiple Myeloma?
mcqIn the management of Multiple Myeloma, which procedure is indicated for impending fractures?
mcqWhich laboratory test is primarily used to diagnose Multiple Myeloma?
mcqWhich of the following treatments is commonly used to manage hypercalcemia in Multiple Myeloma?
mcqWhat is the typical age range for the diagnosis of Multiple Myeloma?
mcqWhat is a common orthopedic complication of Multiple Myeloma?
mcqWhich treatment option is NOT typically used in the orthopedic management of Multiple Myeloma?
mcqWhat is the role of DKK-1 in the pathophysiology of bone destruction in Multiple Myeloma?