Osteomalacia and Rickets
Defective mineralization: osteoid in adults (osteomalacia) vs physis in children (rickets). Etiologies: Vit D deficiency/resistance, phosphate deficiency (tumor‑induced, hereditary), renal tubular acidosis, CKD. Clinical: bone pain, proximal myopathy, waddling gait; in children—wrist/ankle widening, bowing, rachitic rosary, Harrison sulcus. Biochemical: Low Ca/PO4, High ALP, High PTH, Low 25‑OH Vit D (pattern varies in renal disease). Radiology: Looser’s zones; in rickets—widened physes with cup...
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10What is the primary biochemical abnormality found in osteomalacia?
mcqWhich of the following is a classic radiographic finding in rickets?
mcqWhich condition is most commonly associated with vitamin D deficiency in children?
mcqWhat is a common clinical feature of osteomalacia in adults?
mcqIn rickets, which skeletal structure is primarily affected?
mcqWhat is the treatment of choice for X-linked hypophosphatemic rickets (XLH)?
mcqWhich of the following best describes the clinical manifestation of Looser's zones?
mcqWhat would you expect to find on laboratory tests in a patient with osteomalacia?
mcqWhich of the following is a common cause of phosphate deficiency leading to rickets?
mcqWhich physical examination finding is typically associated with rickets in children?