Paget’s Disease of Bone
Focal disorder of accelerated bone turnover: osteoclastic resorption followed by disorganized osteoblastic formation → enlarged, weak, vascular bone. Common sites: pelvis, spine, femur, tibia, skull; often polyostotic; usually age >55. Symptoms: bone pain, deformity (tibia/femur bowing), pathological fractures, skull enlargement, hearing loss; many asymptomatic. Labs: ↑ALP with normal Ca/PO4 (unless immobilization or hyperparathyroidism). Imaging: X‑ray with mixed lytic–sclerotic changes and bon...
Related to
3Practised by MCQ
10What is the most common symptom of Paget's disease of bone?
mcqWhich of the following imaging findings is characteristic of the mixed phase of Paget's disease?
mcqIn Paget's disease, which lab finding is typically elevated?
mcqWhich genetic mutation is most commonly associated with familial cases of Paget's disease?
mcqWhich of the following bones is least likely to be affected by Paget's disease?
mcqWhat is a potential rare complication of Paget's disease?
mcqWhich treatment is primarily used for managing pain in Paget's disease?
mcqWhat age group is primarily affected by Paget's disease?
mcqWhich of the following is a classic radiological feature of Paget's disease in the skull?
mcqWhat is the most common demographic group affected by Paget's disease?