Synovial Sarcoma
High-grade soft tissue sarcoma, often near large joints of extremities (knee, ankle). Affects adolescents and young adults (15–40 years). Histology: biphasic (epithelial + spindle cells) or monophasic; SYT-SSX fusion gene (t[X;18]). Imaging: calcification may be seen on X-ray; MRI shows heterogeneous mass. Treatment: wide excision with radiotherapy; chemotherapy (ifosfamide, doxorubicin) improves survival in advanced cases.
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10What is the most common age group affected by synovial sarcoma?
mcqWhich of the following is the pathognomonic genetic alteration associated with synovial sarcoma?
mcqWhich subtype of synovial sarcoma is characterized by both epithelial and spindle cell components?
mcqWhat is the most common location for synovial sarcoma?
mcqWhich imaging modality is most useful in evaluating synovial sarcoma?
mcqIn synovial sarcoma, which of the following treatment modalities is considered most effective for localized di...
mcqWhich immunohistochemical marker is highly sensitive and specific for synovial sarcoma?
mcqWhat is the prognosis for patients with metastatic synovial sarcoma?
mcqWhat is a characteristic feature of the monophasic subtype of synovial sarcoma?
mcqWhich treatment regimen is typically used for advanced synovial sarcoma?