Orthonotes
by the.bonestories
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Most common malignant tumor of bone overall. Primary sources: breast, prostate, lung, kidney, thyroid. Lesions: breast (mixed), prostate (blastic), lu...
Second most common primary malignant bone tumor in adults. Occurs age 40–70 yrs; M > F. Common sites: pelvis, femur, shoulder girdle, ribs. Variants:...
Enchondroma: intramedullary cartilage tumor, common in hand phalanges. Osteochondroma: cartilage-capped exophytic lesion from metaphysis. Syndromes: O...
Most common primary malignant bone tumor in adults (median age ~65 yrs). Neoplastic proliferation of plasma cells → monoclonal immunoglobulin producti...
Second most common malignant bone tumor in children/adolescents after osteosarcoma. Characterized by t(11;22) → EWS-FLI1 translocation. Common sites:...
Bone scan = radionuclide (Tc-99m MDP) uptake proportional to osteoblastic activity. Highly sensitive for metastasis, stress fractures, infection, AVN....
Localized malignant proliferation of plasma cells in bone or soft tissue without systemic myeloma. Common in vertebrae, pelvis, ribs, femur. Symptoms:...
Limb salvage is preferred over amputation when margins can be obtained and function preserved. Endoprostheses replace resected bone segment, especiall...
Bone allografts used for structural reconstruction after tumor resection. Sources: cadaveric donors; stored in bone banks (fresh-frozen, freeze-dried)...
High-grade soft tissue sarcoma, often near large joints of extremities (knee, ankle). Affects adolescents and young adults (15–40 years). Histology: b...